A5100747949- Gastric Cancer Management and Outcomes
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Metastasis and carcinoma case studies
- Circular RNAs in diseases
- RNA modifications and cancer
- Gastrointestinal Tumor Research and Treatment
- Cancer, Hypoxia, and Metabolism
- Biochemical and Molecular Research
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Screening and Detection
- Colorectal and Anal Carcinomas
- Radiomics and Machine Learning in Medical Imaging
- Resilience and Mental Health
- ATP Synthase and ATPases Research
- Adenosine and Purinergic Signaling
- Gaze Tracking and Assistive Technology
- EEG and Brain-Computer Interfaces
- Nuclear Receptors and Signaling
- Cancer-related gene regulation
- Breast Cancer Treatment Studies
- Pancreatic and Hepatic Oncology Research
- interferon and immune responses
- Breast Lesions and Carcinomas
- Digital Radiography and Breast Imaging
Xiamen University
2011-2025
China Medical University
2014-2024
First Hospital of China Medical University
2009-2024
University of Missouri
2024
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2018-2024
Guangzhou University of Chinese Medicine
2020-2023
ShanghaiTech University
2019-2023
Liaoning Cancer Hospital & Institute
2021-2022
Bioscience (China)
2022
Robotic Technology (United States)
2022
Aberrant expression of miR-335 has been frequently reported in cancer studies, suggesting that there is a close correlation between and during its development, progression, metastasis prognosis. The gastric effects are not known. Relative 4 cell lines 70 tissues was confirmed by real-time quantitative reverse transcriptase-PCR compared with controls. Transwell migration Matrigel invasion assay vitro formation vivo were used to examine the on metastasis. effect proliferation estimated...
The "undruggable" oncogene MYC supports cancer cell proliferation and survival through parallel induction of multiple anabolic processes. Here we find that inhibiting CTP synthase (CTPS) selectively decreases viability induces DNA replication stress in MYC-overexpressing cells. MYC-driven rRNA synthesis caused the selective upon CTPS inhibition. Combined inhibition ataxia telangiectasia Rad3-related protein (ATR) is synthetically lethal cells, promoting death vitro decreasing tumor growth...
Prediction of high-risk depression trajectories in the first year following breast cancer diagnosis with fMRI-related brain connectomics is unclear. The Be Resilient to Breast Cancer (BRBC) study a multicenter trial which 189/232 participants (81.5%) completed baseline resting-state functional magnetic resonance imaging (rs-fMRI) and four sequential assessments (T0-T3). latent growth mixture model (LGMM) was utilized differentiate profiles (high vs. low risk) followed by multivoxel pattern...
Angiotensin II (Ang II) is the predominant effector peptide of renin–angiotensin system. Ang contributes to vascular remodeling in many cardiovascular diseases (eg, hypertension, atherosclerosis, restenosis, and aneurysm). Orphan nuclear receptor Nur77 has a crucial role functional regulation cells. The objective this study was define specific II–induced remodeling. expression initially found be elevated medial smooth muscle cells (VSMCs) thoracic aortas from mice continuously infused with...
CTP synthase (CTPS), the rate-limiting enzyme in de novo biosynthesis, has been demonstrated to assemble into evolutionarily conserved filamentous structures, termed cytoophidia, Drosophila, bacteria, yeast and mammalian cells. However, regulation function of cytoophidium remain elusive. Here, we provide evidence that mechanistic target rapamycin (mTOR) pathway controls assembly Drosophila In cells, find inhibition mTOR attenuates formation. Moreover, CTPS appears be dependent on complex 1...
Aberrant activation of the Wnt/β-catenin signaling pathway plays a major role in carcinogenesis and progression many malignant tumors, especially gastric cancer (GC). Some research has suggested that expression β-catenin protein is associated with clinicopathologic factors affects biological behaviors GC cells. However, mechanism these effects not yet clear. Studies show regulates some miRNAs. We hypothesize oncogenic involved formation through regulating certain microRNAs (miRNAs). The...
Purposes: This study aims to explore the association between brain structural connectivity and 1-year demoralization in patients with newly diagnosed breast cancer. Methods: Patients were enrolled from a multicenter longitudinal program named as Be Resilient Breast Cancer (BRBC) 2017 2019. Brain was assessed diffusion tensor imaging (DTI) at baseline scale II collected self-report data 1 year later. A data-driven correlational tractography performed recognize significant neural pathways...
The collagen and elastin are important components of extracellular matrix (ECM) in the nucleus pulposus (NP), which can produce water‑insoluble proteins through cross‑linkages to stabilize ECM. Lysyl oxidase (LOX), a copper‑dependent amine oxidase, insolubilizes ECM keep stability by initiating cross‑linkages. present study aimed investigate relationships between intervertebral disc (IVD) degeneration LOX expression human NP. A total 22 cases with lumbar IVD were designed observed group...
Introduction LDH-A, the enzyme responsible for transforming pyruvate into lactate, has been demonstrated to be up-regulated in many types of cancer and give rise more aggressive behavior by regulating proliferation anti-apoptosis. However, its expression gastric (GC) not characterized thoroughly. The purpose this study was clarify potential impact LDH-A GC. Methods We examined immunohistochemistry on GC tissue microarray (TMA) using Western blot fresh tissues cell lines. Prognostic value...
The pre-leukemia transcription factor 3 (PBX3) is a member of the PBX family factors, which known to increase DNA-binding/transcriptional activity HOX proteins and regulate genes involved in development. Recently, PBX3 was reported be variety cancers, while its implication gastric cancer unclear. This study aimed investigate clinical significance biological function cancer. expression analyzed 90 specimens using immunohistochemistry. overexpressed 30 cases (33.33%). Importantly,...
Abstract Background The 8th edition of the American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) pathological tumor‐node‐metastasis (pTNM) staging system may have increased accuracy in predicting prognosis gastric cancer due to its important modifications from previous editions. However, homogeneity within each subgroup classified according still exist. This study aimed compare and analyze prediction abilities 7th editions AJCC/UICC pTNM propose a modified...
BACKGROUND Conditional survival estimates, which take into consideration the changing risk with increasing time, provide a dynamic probability and more accurate information for clinician decision making. The objective of current study was to evaluate conditional disease‐specific (DSS) patients gastric cancer who underwent curative surgery in China. METHODS In total, 7658 from multi‐institutional cohort China were included analyses. Actuarial DSS estimated using Kaplan‐Meier method....
To investigate the clinical significance of ubiquitin-specific peptidase 19 (USP19) expression in gastric cancer (GC) compared with that normal tissues and cell lines.USP19 protein was analyzed 212 paired GC samples using immunohistochemical staining. Quantitative real-time PCR (qRT-PCR) Western blotting were used to detect level USP19 lines. The biological functions investigated by MTT assay, colony-forming wound healing assay gelatin zymography, apoptotic cells detected...
Abstract Background Gastric cancer (GC) is a common cause of cancer-related mortality worldwide, and microRNAs (miRNAs) have been shown to play an important role in GC development. This study aims explore the effect microRNA-93-5p (miR-93-5p) on epithelial-mesenchymal transition (EMT) GC, via AHNAK Wnt signaling pathway. Methods Microarray-based gene expression analysis was performed identify GC-related differentially expressed miRNAs genes. Then miR-93-5p examined tissues cell lines. The...
Peritoneal dissemination is one of the main causes death in gastric cancer patients. Transforming growth factor-beta1 (TGF-β1), most potent fibrotic stimuli for mesothelial cells, may play a key role this processing. The purpose study to elucidate effects TGF-β1 on regulation adhesion cells.Peritoneal tissues and peritoneal wash fluid were obtained hematoxylin eosin staining or ELISA measure fibrosis levels, respectively. cell line, HMrSV5, was used determine cells expression collagen,...