A5101811417- Endometriosis Research and Treatment
- Endometrial and Cervical Cancer Treatments
- Circular RNAs in diseases
- RNA Research and Splicing
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Reproductive System and Pregnancy
- RNA regulation and disease
- Uterine Myomas and Treatments
- Thermoregulation and physiological responses
- Genomics and Chromatin Dynamics
- Heat shock proteins research
- Climate Change and Health Impacts
- MicroRNA in disease regulation
China Medical University
2011-2025
Fudan University Shanghai Cancer Center
2024
Shanghai Pudong New Area Gongli Hospital
2020
Second Military Medical University
2020
Aberrant expression of miR-335 has been frequently reported in cancer studies, suggesting that there is a close correlation between and during its development, progression, metastasis prognosis. The gastric effects are not known. Relative 4 cell lines 70 tissues was confirmed by real-time quantitative reverse transcriptase-PCR compared with controls. Transwell migration Matrigel invasion assay vitro formation vivo were used to examine the on metastasis. effect proliferation estimated...
Abstract Endometriosis is a common and benign gynecological disorder but exhibits malignant features. However, the underlying pathogenesis pathophysiology of endometriosis remain unclear. Circular RNAs have been demonstrated to participate in occurrence progression multiple diseases. This study was aimed explore roles circATRNL1 vitro. Based on results reverse transcription-quantitative polymerase chain reaction analysis, we found significant upregulation Yes-associated protein 1 ( YAP1) ,...
Abstract Background Circular RNAs (circRNAs) with miRNA response elements (MREs) could function as competing endogenous RNA (ceRNA) in regulating gene expression, thus playing vital roles pathogenesis and progression of many diseases. However, the circRNAs endometriosis remains unknown. This study was carried to profile expression patterns ovarian endometriosis. Methods High throughput RNA‐Seq performed six paired ectopic eutopic endometrium tissues (ecEM vs. euEM), followed by quantitative...
We previously performed high throughput RNA-seq in paired eutopic and ectopic endometrial specimen of endometriosis patients, validated the results by qRT-PCR tissues. MiR-96-5p was significantly downregulated tissues compared to In order identify role miR-96-5p cells, investigate underlying mechanisms, Ishikawa End1/E6E7 cell lines were transfected with mimics, inhibitors or TGFBR1 siRNA. The expression TGF-β/SMAD signaling pathway components epithelial–mesenchymal transition (EMT) markers...
Androgenetic alopecia (AGA), or male pattern baldness (MPB), is the most common form of hair loss in males. A combination genetic and androgen causes have been suggested as factors that contribute to development AGA. However, specific molecular mechanisms underly AGA remain largely unknown. Long non-coding RNAs (lncRNAs), a new class regulatory are longer than 200 nucleotides, shown play important roles number cellular processes, including transcription, chromosome remodelling...
Sepsis is a severe system inflammatory response syndrome in to infection. The vascular endothelium cells play key role sepsis-induced organ dysfunction. heat shock protein 70 (HSP70) has been reported an anti-inflammatory and protect from sepsis. present study aimed at finding the function of HSP70 against sepsis cells. Lipopolysaccharide (LPS) agonist inhibitor were used treat HUVEC. Cell permeability was measured by transepithelial electrical resistance (TEER) assay FITC-Dextrans. junction...