A5081363438- Marine and coastal ecosystems
- Aquatic Ecosystems and Phytoplankton Dynamics
- Nuclear Receptors and Signaling
- Microbial Community Ecology and Physiology
- Synthesis and Characterization of Heterocyclic Compounds
- Marine Biology and Ecology Research
- Retinoids in leukemia and cellular processes
- Marine Toxins and Detection Methods
- Marine Bivalve and Aquaculture Studies
- Geochemistry and Elemental Analysis
- Synthesis and biological activity
- Isotope Analysis in Ecology
- Oceanographic and Atmospheric Processes
- Algal biology and biofuel production
- Protist diversity and phylogeny
- Macrophage Migration Inhibitory Factor
- Synthesis of Tetrazole Derivatives
- Coagulation and Flocculation Studies
- Coastal wetland ecosystem dynamics
- Environmental Toxicology and Ecotoxicology
- Wastewater Treatment and Nitrogen Removal
- Biocrusts and Microbial Ecology
- Methane Hydrates and Related Phenomena
- Water Quality Monitoring and Analysis
- Adsorption and biosorption for pollutant removal
Chinese Academy of Sciences
2016-2025
University of Chinese Academy of Sciences
2018-2025
Institute of Oceanology
2016-2025
Qingdao National Laboratory for Marine Science and Technology
2016-2025
Xinjiang Medical University
2025
First Affiliated Hospital of Henan University
2025
Laoshan Laboratory
2023
Guangxi Academy of Sciences
2023
Institute of Oceanology
2011-2022
IGE Therapeutics (United States)
2022
TR3, an immediate-early response gene and orphan member of the steroid-thyroid hormone-retinoid receptor superfamily transcription factors, regulates apoptosis through unknown mechanism. In to apoptotic stimuli, TR3 translocates from nucleus mitochondria induce cytochrome c release apoptosis. Mitochondrial targeting but not its DNA binding transactivation, is essential for proapoptotic effect. Our results reveal a mechanism by which nuclear factor initiate
TR3, also known as NGFI-B or nur77, is an immediate-early response gene and orphan member of the steroid/thyroid/retinoid receptor superfamily. We previously reported that TR3 expression was induced by apoptotic stimuli required for their effect in lung cancer cells. Here, we present evidence epidermal growth factor (EGF) serum mitogenic Ectopic both H460 Calu-6 cell lines promoted cycle progression BrdU incorporation, while inhibition small interfering RNA approach suppressed EGF serum....
Retinoid X receptor (RXR) plays a central role in the regulation of intracellular signaling pathways by acting as ubiquitous heterodimerization partner many nuclear receptors, including orphan Nur77 (also known TR3 [corrected] or NGFI-B), which translocates from nucleus to mitochondria, where it interacts with Bcl-2 induce apoptosis. Here, we report that RXRalpha is required for export and mitochondrial targeting through their unique mediated dimerization interfaces located DNA-binding...
The orphan nuclear receptor Nur77 is an immediate-early response gene whose expression rapidly induced by various extracellular stimuli. aims of this study were to the role in growth and survival colon cancer cells mechanism which was regulated. We showed that levels elevated a majority human tumors (9/12) compared their nontumorous tissues could be strongly different colonic carcinogens including deoxycholic acid (DCA). DCA-induced resulted up-regulation antiapoptotic BRE angiogenic VEGF,...
Chitosan is a natural and eco-friendly material, often used as flocculant in water purification; however, due to the influences of high salinity pH, application chitosan seawater has been greatly limited. In this paper, modified (3-chloro-2-hydroxypropyl trimethyl ammonium chloride (CTA) chitosan, denoted CTC) was prepared by chemical modification. This increased solubility both deionized seawater, solved technical difficulty applying seawater. The structure CTC its solubilization on were...
Retinoic acid receptor β (RARβ) plays a critical role in mediating the anticancer effects of retinoids. Expression RARβ is highly induced by retinoic (RA) through RA response element (βRARE) that activated heterodimers RARs and retinoid X receptors (RXRs). However, induction often lost cancer cells despite expression RXRs. In this study, we provide evidence orphan COUP-TF required for expression, growth inhibition, apoptosis cells. correlates with variety cell lines. addition, stable...
Abstract In spring 2014 (May–June), in the southern East China Sea (ECS) and east of Taiwan, nutrient isotope samples were collected analyzed. Also, dissolved oxygen (DO), chlorophyll‐ a , physical parameters determined. The Kuroshio subsurface water intruded into ECS separated two branches on continental shelf: nearshore branch current (NKBC) offshore (OKBC). Nitrate concentration slightly decreased Taiwan by assimilation was supplied upwelling currents northeast Taiwan. variations DO,...
Introduction/Objective: The alkaloids of songorine, aconitine, and benzoylaconitine, as the processed products Aconitum soongaricum Stapf., can significantly inhibit migration invasion ovarian cancer cells in vitro. Herein, we studied vivo role mechanism these natural A. Stapf. Methods: A xenograft tumor model was constructed. Tumor volumes weights were calculated. HE staining assessed histopathological changes tumors. Inflammatory factors detected using ELISA. Gene protein expressions...
Bacillus amyloliquefaciens is a commonly used probiotic microecological regulator in aquaculture water with the ability to inhibit harmful algae blooms (HABs) and improve health status of ecosystem. Modified clay has been widely applied field for eliminating HABs. In this study, particles are as carriers provide microenvironment microbial fermentation, yielding modified product high efficiency typical HAB organisms. Methods developed fermentation microorganisms also subsequent preparation...
Abstract Shikonin derivatives, which are the active components of medicinal plant Lithospermum erythrorhizon, exhibit many biological effects including apoptosis induction through undefined mechanisms. We recently discovered that orphan nuclear receptor Nur77 migrates from nucleus to mitochondria, where it binds Bcl-2 induce apoptosis. Here, we report certain shikonin derivatives could modulate Nur77/Bcl-2 apoptotic pathway by increasing levels protein and promoting its mitochondrial...