A5101866401- Traumatic Brain Injury and Neurovascular Disturbances
- Intracerebral and Subarachnoid Hemorrhage Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Acute Ischemic Stroke Management
- S100 Proteins and Annexins
- Cancer-related gene regulation
- Extracellular vesicles in disease
- Neonatal Respiratory Health Research
- Inflammasome and immune disorders
- Estrogen and related hormone effects
- Heme Oxygenase-1 and Carbon Monoxide
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Congenital Diaphragmatic Hernia Studies
- Retinoids in leukemia and cellular processes
- Ubiquitin and proteasome pathways
- Pancreatic function and diabetes
- Endoplasmic Reticulum Stress and Disease
- Diabetes Treatment and Management
- Mitochondrial Function and Pathology
- Nuclear Receptors and Signaling
- Pleural and Pulmonary Diseases
- Neurosurgical Procedures and Complications
- Glioma Diagnosis and Treatment
- Heat shock proteins research
Guangdong Province Women and Children Hospital
2021-2025
Tianjin University of Science and Technology
2025
China International Science and Technology Cooperation
2025
Zhongshan Hospital of Xiamen University
2024
Tianjin Huanhu Hospital
2018-2024
Tianjin Children's Hospital
2023
Tianjin University
2023
Shanghai East Hospital
2021-2022
Nanjing Medical University
2021-2022
Nanjing University of Chinese Medicine
2022
Neuroinflammation is an important secondary injury mechanism that has dual beneficial and detrimental roles in the pathophysiology of traumatic brain (TBI). Compelling data indicate statins, a group lipid-lowering drugs, also have extensive immunomodulatory anti-inflammatory properties. Among atorvastatin been demonstrated as neuroprotective agent experimental TBI; however, there lack evidence regarding its effects on neuroinflammation during acute phase TBI. The current study aimed to...
Cerebral ischemia-reperfusion (I/R) injury is a major cause of early complications and unfavorable outcomes after endovascular thrombectomy (EVT) therapy in patients with acute ischemic stroke (AIS). Recent studies indicate that modulating microglia/macrophage polarization subsequent inflammatory response may be potential adjunct to recanalization. Annexin A1 (ANXA1) exerts potent anti-inflammatory pro-resolving properties models cerebral I/R injury. However, whether ANXA1 modulates...
Significance HSP70 proteins are well known as molecular chaperones involved in protein folding and quality control. Whether they also function gene transcription on chromatin, if so, how regulated, remains elusive. Here we report that can regulate through its association with distinct from “classic” a chaperone. The of is subject to regulation an arginine methylation highly conserved residue HSP70, which modulates the recruitment key component pre-initiation complex, thus initiation. present...
While protein arginine methyltransferases (PRMTs) and PRMT-catalyzed methylation have been well-known to be involved in a myriad of biological processes, their functions the underlying molecular mechanisms cancers, particularly estrogen receptor alpha (ERα)-positive breast remain incompletely understood.Here we focused on investigating PRMT4 (also called coactivator associated methyltransferase 1, CARM1) ERα-positive cancers due its high expression poor prognosis.Methods: ChIP-seq RNA-seq...
Bronchopulmonary dysplasia (BPD) frequently occurs in preterm infants, causing significantly impaired lung function and increased mortality rates. Studies on plasma protein levels can facilitate early detection of BPD, enabling prompt intervention a decrease mortality. We conducted prospective observational study involving proteomic sequencing samples from 19 infants. Our analysis included principal component analysis, volcano plots, heatmap enrichment receiver operating characteristic (ROC)...
The association between the presence of common pathogens in maternal cervicovaginal tract as well neonatal gastric fluid and adverse outcomes preterm newborns remains uncertain. Cervicovaginal swabs were collected from 98 mothers, specimens obtained 121 premature infants with gestational ages ≤ 32 weeks within 24 h birth. Thirteen tested using suspension microarray. Neonatal monitored until either death or discharge. was predominant species identified both fluid. Preterm Ureaplasma at birth...
Traumatic brain injury (TBI) is one of the leading causes trauma-induced mortality and disability, emerging studies have shown that endoplasmic reticulum (ER) stress plays an important role in pathophysiology TBI. Tauroursodeoxycholic acid (TUDCA), a hydrophilic bile acid, has been reported to act as ER inhibitor chemical chaperone potential attenuate apoptosis inflammation. To study effects TUDCA on injury, we subjected mice TBI with controlled cortical impact (CCI) device. Using western...
Yin Yang 1 (YY1) is a multifunctional transcription factor shown to be critical in variety of biological processes. Although it regulated by multiple types post-translational modifications (PTMs), whether YY1 methylated, which enzyme methylates YY1, and hence the functional significance methylation remains completely unknown. Here we reported first methyltransferase, SET7/9 (KMT7), capable methylating at two highly conserved lysine (K) residues, K173 K411, located distinct domains, one...
Traumatic brain injury (TBI) induces the excessive inflammation and disruption of blood-brain barrier, both which are partially mediated by activation microglia release inflammatory cytokines. Previous reports showed that administration regulatory T cells (Tregs) could suppress promote neurological function recovery, IL-2/anti-IL-2 complex(IL-2C) increase number Tregs. Thus, we hypothesized IL-2C-mediated expansion Tregs would be beneficial in mice subjected to TBI. In this study, received...
An imbalance of immune/inflammatory reactions aggravates secondary brain injury after traumatic (TBI) and can deteriorate clinical prognosis. So far, not enough therapeutic avenues have been found to prevent such an in the setting. Progesterone has shown regulate many diseases conveys a potential protective role TBI. This study was designed investigate neuroprotective effects progesterone associated with modulation experimental A TBI model adult male C57BL/6J mice created using controlled...
Our recent discovery of the substituted cyclobutane Boc5, one first non-peptidic agonists at glucagon-like peptide-1 receptors, offers potential combining oral availability with full agonism capable eliciting antidiabetic and antiobesity effects. The present study was aimed determining in vivo pharmacologic properties Boc5 both normal diabetic mice following chronic administration, emphasis on glycemic control weight loss.C57BL/6J db/db were treated daily for 4 weeks a range parameters,...
Rationale: Glycogen synthase kinase-3β (GSK-3β) plays key roles in metabolism and many cellular processes. It was recently demonstrated that overexpression of GSK-3β can confer tumor growth. However, the expression function hepatocellular carcinoma (HCC) remain largely unexplored. This study is aimed at investigating role therapeutic target value HCC. Methods: We firstly clarified human HCC samples. Given deviated retinoid signalling critical for development, we studied whether could be...