A5049249579- Intracerebral and Subarachnoid Hemorrhage Research
- Spinal Hematomas and Complications
- Neurosurgical Procedures and Complications
- Neuroinflammation and Neurodegeneration Mechanisms
- Mitochondrial Function and Pathology
- Endoplasmic Reticulum Stress and Disease
- Immune cells in cancer
- Spinal Fractures and Fixation Techniques
- Extracellular vesicles in disease
- Pancreatic and Hepatic Oncology Research
- Neurofibromatosis and Schwannoma Cases
- DNA Repair Mechanisms
- Nuclear Receptors and Signaling
- Autophagy in Disease and Therapy
- Glioma Diagnosis and Treatment
- Immune Response and Inflammation
- Tuberous Sclerosis Complex Research
- Angiogenesis and VEGF in Cancer
- Chemokine receptors and signaling
- Telomeres, Telomerase, and Senescence
- Vascular Malformations Diagnosis and Treatment
- Neonatal and fetal brain pathology
- Axon Guidance and Neuronal Signaling
- Barrier Structure and Function Studies
- Heme Oxygenase-1 and Carbon Monoxide
Tianjin Medical University General Hospital
2017-2022
Tianjin Medical University
2017-2021
Karolinska Institutet
2020-2021
Karolinska University Hospital
2020-2021
The Neurological Institute
2020
Traumatic brain injury (TBI) is one of the leading causes trauma-induced mortality and disability, emerging studies have shown that endoplasmic reticulum (ER) stress plays an important role in pathophysiology TBI. Tauroursodeoxycholic acid (TUDCA), a hydrophilic bile acid, has been reported to act as ER inhibitor chemical chaperone potential attenuate apoptosis inflammation. To study effects TUDCA on injury, we subjected mice TBI with controlled cortical impact (CCI) device. Using western...
Mutations of telomerase reverse transcriptase (TERT) and the α thalassemia/mental retardation syndrome X-linked (ATRX) genes have been subject numerous studies on classification prognosis glioma. However, association between TERT ATRX in World Health Organization (WHO) grade II to IV glioma remains unclear. The present study utilized Sanger sequencing immunohistochemical methods detect expression promoter region, mutations proliferation marker protein Ki-67 (Ki-67) 179 cases current analyzed...
Microglia, predominant parenchymal resident macrophages in the central nervous system (CNS), are crucial players neurodevelopment and CNS homeostasis. In disease conditions, pro-inflammatory microglia predominate over their regulatory counterparts, thus a potential immunotherapeutic target. It has been well documented that can be effectively depleted using both conditional genetic Cx3cr1Cre-diphtheria toxin receptor (DTR)/diphtheria subunit A (DTA) animal models pharmacological...
Semaphorin 3A (SEMA3A) is a member of the Semaphorins family, class membrane-associated protein that participates in construction nerve networks. SEMA3A has been reported to affect vascular permeability previously, but its influence traumatic brain injury (TBI) still unknown. To investigate effects SEMA3A, we used mouse TBI model with controlled cortical impact (CCI) device and BBB vitro oxygen-glucose deprivation (OGD). We tested post-TBI changes related receptors (Nrp-1 plexin-A1)...
Our previous study showed that the combination therapy with atorvastatin and low-dose dexamethasone protected endothelial cell function in chronic subdural hematoma (CSDH) injury. In this study, we aimed to investigate mechanism underlying effects of on CSDH-induced dysfunction.Monocytes cells were cocultured CSDH patient samples mimic pathological microenvironment CSDH. Monocytes (THP-1 cells) (hCMEC/D3 a transwell system for 24 h before stimulation diluted medium (ECM) at 1:1 ratio. Tight...
This study investigated the surgical results of a single-stage posterolateral approach with arc incision, unilateral laminectomy, and costotransversectomy for management dumbbell tumors paraspinal thoracic spine. From January 2010 to March 2017, 14 patients or spine who underwent resection were followed up analyzed retrospectively. The operations performed using without any instrumentation. We reviewed scores clinical symptoms imaging results, including postoperative MRI reconstructed 3D-CT...
Atorvastatin has been shown to be a safe and effective non-surgical treatment option for patients with chronic subdural hematoma. However, atorvastatin is not in some patients, who must undergo further surgical treatment. Dexamethasone anti-inflammatory immunomodulatory effects, low dosages are the of many diseases, such as ankylosing spondylitis community-acquired pneumonia. effects low-dose dexamethasone hematoma remain poorly understood. Hematoma samples admitted General Hospital Tianjin...
Tyrosine phosphatase receptor type N (PTPRN) plays an important role in the regulation of secretion pathways various neuroendocrine cells. Moreover, PTPRN was demonstrated to play a crucial initiation and progression signalling cascade regulating cell function. In this study, fifty-seven glioma patients were enrolled for clinical prognostic analyses. The phenotype determined by proliferation migration assays. RNA-seq, co-IP mass spectrometry used study molecular mechanism effects on...
Previous studies found that atorvastatin and dexamethasone were effective in promoting the absorption of chronic subdural hematoma. In this study, we aimed to investigate effect pharmacotherapy an optimized rat model Rat hematoma via a bEnd.3 cell Matrigel mix was established dynamic changes different drug treatment groups tested. The gradually increased, peaked on fifth day (263.8±52.85 μl), completely absorbed two weeks. Notably, Kruppelle-like factor 2 expression significantly decreased...
The aims of this study were to evaluate the feasibility a new rapid tumor resection technique using soft coagulation monopolar suction (SCMS) and strengthen neurosurgeons' understanding, use, attention electrosurgical technique. surgical used herein comprised in mode applied by ERBE VIO 300s workstation conventional microsurgical suction. We supratentorial tumors 12 patients (5 with glioblastomas, 4 astrocytomas, 2 metastases, one lymphoma) as SCMS group. bipolar electrocautery method was...