A5108046308- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Immune Response and Inflammation
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Intracranial Aneurysms: Treatment and Complications
- Neurogenesis and neuroplasticity mechanisms
- Congenital Anomalies and Fetal Surgery
- Pelvic and Acetabular Injuries
- Parasitic infections in humans and animals
- Intracerebral and Subarachnoid Hemorrhage Research
- Glioma Diagnosis and Treatment
- Hemoglobinopathies and Related Disorders
- Modular Robots and Swarm Intelligence
- Advanced Materials and Mechanics
- Hernia repair and management
- Structural Analysis and Optimization
- Orthopaedic implants and arthroplasty
- Nerve injury and regeneration
- Chemokine receptors and signaling
- Gastrointestinal disorders and treatments
- Planetary Science and Exploration
- Nuclear Receptors and Signaling
- Robotic Path Planning Algorithms
- Congenital gastrointestinal and neural anomalies
Karolinska Institutet
2016-2025
West China Hospital of Sichuan University
2024
Zhengzhou Children's Hospital
2020-2022
Zhengzhou University
2022
University of Gothenburg
2022
Army Medical University
2015-2021
Xinqiao Hospital
2017-2021
Karolinska University Hospital
2020
Jiangxi Provincial People's Hospital
2011
Xinjiang Medical University
2010
Blood-brain barrier (BBB) disruption aggravates brain injury induced by intracerebral hemorrhage (ICH); however, the mechanisms of BBB damage caused ICH remain elusive. Mfsd2a (major facilitator superfamily domain containing 2a) has been known to play an essential role in formation and function. In this study, we investigated underlying permeability regulation after ICH.Using models, found that protein expression perihematomal tissues was significantly decreased ICH. Knockdown knockout mice...
The relative contribution of resident microglia and peripheral monocyte-derived macrophages in neuroinflammation after cranial irradiation is not known. A single dose 8 Gy was administered to postnatal day 10 (juvenile) or 90 (adult) CX3CR1GFP/+ CCR2RFP/+ mouse brains. Microglia accumulated the subgranular zone hippocampal granule cell layer, where progenitor death prominent. peak earlier (6 h vs. 24 h) but less pronounced adult increase juvenile, adult, brains partly attributed...
Cranial irradiation (IR), an effective tool to treat malignant brain tumors, triggers a chronic pro-inflammatory microglial response, at least in the adult brain. Using single-cell and bulk RNA sequencing, combined with histology, we show that response juvenile mouse hippocampus is rapid but returns toward normal within 1 week. The characterized by series of temporally distinct homeostasis-, sensome-, inflammation-related molecular signatures. We find single cell simultaneously upregulates...
Cranial radiotherapy causes progressive neurocognitive impairments in cancer survivors. Neuroinflammation is believed to be a key contributor, but its dynamics and consequences for brain function remain poorly understood. Here, we performed comprehensive longitudinal profiling, from 6 hours 1 year after irradiation (IR) of the mouse hippocampus, using transcriptomic, protein histological analyses. We identified delayed microglial response coupling interferon signaling mitotic progression,...
Microglia, predominant parenchymal resident macrophages in the central nervous system (CNS), are crucial players neurodevelopment and CNS homeostasis. In disease conditions, pro-inflammatory microglia predominate over their regulatory counterparts, thus a potential immunotherapeutic target. It has been well documented that can be effectively depleted using both conditional genetic Cx3cr1Cre-diphtheria toxin receptor (DTR)/diphtheria subunit A (DTA) animal models pharmacological...
Fluorescent reporter labeling and promoter-driven Cre-recombinant technologies have facilitated cellular investigations of physiological pathological processes, including the widespread use Cx3cr1CreER-Eyfp/wt mouse strain for studies microglia.Immunohistochemistry, Flow Cytometry, RNA sequencing whole-genome were used to identify subpopulation microglia in brains. Genetically mediated depletion using Cx3cr1CreER-Eyfp/wtRosa26DTA/wt mice CSF1 receptor inhibitor PLX3397 deplete microglia....
This retrospective study is to investigate the safety and efficacy of stent implanting for treating severe symptomatic atherosclerotic stenosis intracranial vertebrobasilar artery (ICVBA). 213 patients who had undergone intervention ICVBA between September 2012 May 2018 were enrolled into this study. Among patients, 210 (98.6%) obtained successfully revascularization 206 (96.7%) good after stenting. The extent before was 86.3 ± 6.8% 9.1 3.7%, respectively. Within 90 days stenting, 10 (4.7%)...
Multiple sclerosis (MS) is a chronic neuroinflammatory disorder of the central nervous system (CNS) that usually presents in young adults and predominantly females. Microglia, major resident immune cell CNS, are critical players both CNS homeostasis disease. We have previously demonstrated microglia can be efficiently depleted by administration tamoxifen Cx3cr1CreER/+Rosa26DTA/+ mice, with ensuing repopulation deriving from proliferation residual engraftment peripheral monocyte-derived...
Background: Percutaneous transluminal angioplasty and stenting with the Wingspan stent has proven safe effective in patients middle cerebral artery stenosis (MCAS), but off-label use of Neuroform might be an alternative treatment. This study aimed to compare safety effectiveness above two intracranial stents MCAS. Methods: We retrospectively analyzed consecutive symptomatic MCAS who had been treated EZ or stent. A propensity score was generated control for differences baseline...
Abstract Cranial irradiation (IR) is one of the pillars treatment brain tumors and metastases, but it causes progressive neurocognitive impairments in cancer survivors. Neuroinflammation believed to contribute this, its dynamics consequences on function remain poorly understood. Here, we performed longitudinal molecular cellular profiling irradiated mouse hippocampus, a key structure for cognitive tasks, using single cell transcriptomics computational analyses, proteomics histology, covering...
Abstract Background The cerebellum is involved in hyperactivity, fear, and anxiety disorders that could be induced by whole-brain irradiation (WBI). However, whether cerebellar alone (CIA) induce these unknown. We investigated the effect of CIA an animal model. Methods Eleven-day-old rat pups underwent a single 3-Gy dose either WBI ( n = 28) or 20), while 34 were sham-irradiated (controls). Cell death was evaluated subgranular zone hippocampus counting pyknotic cells after haematoxylin/eosin...
Objective To evaluate low-weight mesh for tension-free repair of inguinal hernia in the elders. Methods 120 old patients ( age at 60 -97 years) underwent by using mesh. The early complications, time up and about, hospital stay, postoperative chronic pain,foreign body feelings recurrence were analyzed. Results operations successful all cases average operation was (43 ± 12 ) min. 9 suffered from edema scrotum, 5 urine retention, 4 incision hematoma. outof-bed 17.4 1.8 h, days 7.4 1.9) d....
Objective To investigate the clinical manefesnation,diagnosis and treatment of brain echinococcosis.Method The details a rare case echinococcosis was reported.We also retrospectively studied series 19 patients treated from 1990 to 2008.Results Total excision performed in all patients.There no recurrence during short follow-up period.Conclusions Having multiple forms image manefestination,preoperation diagnosis for helps establish methods including surgical strategy.Total removal could heal...
Cerebral hemorrhage is a serious complication of intracranial artery stenting that could be fatal without timely identification and treatment. Prompt brain CT scan would help to evaluate whether cerebral occurs, however, the diverse features immediately after influence judgement sometimes. Therefore, we analyzed summarized these determine clinical significance features. The prompt were classified into three types. Type I indicates no high-density shadows. II shadows scattered in infarct...