A5032791277- Cancer Cells and Metastasis
- Neurogenesis and neuroplasticity mechanisms
- Glioma Diagnosis and Treatment
- Chromium effects and bioremediation
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related cognitive impairment studies
- Cancer-related molecular mechanisms research
- Inflammatory Myopathies and Dermatomyositis
- Neuroscience and Neuropharmacology Research
- Chemical Reactions and Isotopes
- Celiac Disease Research and Management
- COVID-19 Clinical Research Studies
- Immunodeficiency and Autoimmune Disorders
- Cancer Research and Treatments
- COVID-19 and healthcare impacts
- Extracellular vesicles in disease
- Chromosomal and Genetic Variations
- Long-Term Effects of COVID-19
- Cardiac Structural Anomalies and Repair
- Histiocytic Disorders and Treatments
- Systems Engineering Methodologies and Applications
- MicroRNA in disease regulation
- Cystic Fibrosis Research Advances
- Pelvic and Acetabular Injuries
- Chemokine receptors and signaling
Karolinska Institutet
2022-2025
Fundación Ramón Domínguez
2023
Zhengzhou Children's Hospital
2023
Center for Children
2023
Zhengzhou University
2023
Centro Hospitalar do Baixo Vouga
2020-2022
Instituto Politécnico de Santarém
2021
Hospital Curry Cabral
2021
Hospital de Egas Moniz
2021
Universidade Estadual do Oeste do Paraná
2021
Abstract Cancer stem cells (CSCs) are a small population of resistant inhabiting the tumors. Although comprising only nearly 3% tumor mass, these were demonstrated to orchestrate tumorigenesis and differentiation, underlie tumors’ heterogeneity mediate therapy resistance relapse. Here we show that CSCs may be formed by dedifferentiation terminally differentiated under stress conditions. Using elegant co-culture cellular system, able prove nutrients oxygen deprivation activated non-malignant...
Cranial radiotherapy causes progressive neurocognitive impairments in cancer survivors. Neuroinflammation is believed to be a key contributor, but its dynamics and consequences for brain function remain poorly understood. Here, we performed comprehensive longitudinal profiling, from 6 hours 1 year after irradiation (IR) of the mouse hippocampus, using transcriptomic, protein histological analyses. We identified delayed microglial response coupling interferon signaling mitotic progression,...
Glioblastoma, aggressive primary brain tumors with a dismal prognosis, promote the recruitment of microglia, resident innate immune cells, and ultimately their activation toward tumor-supportive phenotype that increases gliomal proliferation invasion capability. Here, we report upon stimulation by glioma microglia transit via reactive state holding anti-tumoral properties coupled to reduced DNMT3A chromatin occupancy DNA demethylation microglial pro-inflammatory gene expressions. We find...
Autoimmune enteropathy is normally characterised by crypt hyperplastic villous atrophy with enterocyte autoantibodies, activation of mucosal lymphocytes and increased epithelial HLA-DR. This case involved a severely affected Portuguese infant who was found to have lymphocyte deficiency demonstrated correspondingly distinct features.A female nonconsanguineous parents treated for vomiting diarrhoea, first milk exclusion then parenteral nutrition. Lymphocyte subsets immunoglobulin...
Cancer is one of the major threats to human health and, due distinct factors, it expected that its incidence will increase in next decades leading an urgent need new anticancer drugs development. Ongoing experimental and clinical observations propose cancer cells with stem-like properties (CSCs) are involved on development lung chemoresistance. As tumour growth metastasis can be controlled by tumour-associated stromal cells, main goal this study was access antitumor potential five...
Cellular senescence is a physiological process that serves as powerful barrier for tumorigenesis. However, senescent cells can be deleterious the tissue microenvironment. Such case of fibroblasts release several pro-tumorigenic factors promote malignant transformation in nearby epithelial cells. Occupational exposure to hexavalent chromium [Cr(VI)] compounds cause respiratory cancers. Although Cr(VI) known induce human foreskin fibroblasts, role Cr(VI)-induced bronchial was never assessed....
Bone remodelling represents the most remarkable bone response to mechanical stress and mineral homeostasis. It is consequence of complex highly orchestrated tightly regulated cellular processes taking place in a specialised entity - compartment (BRC).Cementum an understudied tissue that requires more research understand its biology, pathology, potential for regeneration. Although analogue structure composition distinct structural functional differences were ascribed each these mineralised...
Cranial irradiation (IR) negatively regulates hippocampal neurogenesis and causes cognitive dysfunctions in cancer survivors, especially pediatric patients. IR decreases proliferation of neural stem/progenitor cells (NSPC) consequently diminishes production new neurons. Memantine, an NMDA receptor antagonist, used clinically to improve cognition patients suffering from Alzheimer's disease dementia. In animal models, memantine acts as a potent enhancer neurogenesis. Memantine was recently...
A non-smoking woman in her sixties had cylindrical bronchiectasis secondary to pulmonary tuberculosis acquired when aged 16 for which she received 12 months of antituberculous therapy. Multiple subsequent admissions followed with non-tuberculous infections. Recent CT images showed extensive bilateral upper lobe (figures 1 and 2). Despite clinical functional deterioration, remains independent using bronchodilators, continuous oxygen therapy combined non-invasive nocturnal ventilation...
Inverted duplications (inv dup) of a terminal chromosome region are particular subset rearrangements that often results in partial tetrasomy or trisomy when accompanied by deleted chromosome. Associated mosaicism could be the consequence post-zygotic event result from correction trisomic conception. Tetrasomies distal segments 3q rare genetic events and their phenotypic manifestations diverse. To our knowledge, there only 12 cases reported with tetrasomy. Generally, individuals this genomic...
Abstract In the 1920s, Otto Warburg reported a striking metabolic shift in solid tumors: contrary to their normal counter parts, which exhibited nearly pure respiratory metabolism, where cancer cells relied strongly on lactic fermentation for energy production, even presence of ample oxygen. This shift, later named effect, is now viewed as universal phenotype. To investigate whether it operating hexavalent chromium (Cr(VI))-induced carcinogenesis, PC-12 were exposed low Cr(VI) concentrations...
Abstract Medulloblastoma (MB) is the most common high-grade paediatric brain tumour, accounting for ~20 % of all childhood CNS tumours. It comprised 4 distinct molecular subtypes, with Group 3 MB having worst prognosis an overall survival around 50 %. Additionally, current treatments, especially radiotherapy (RT), come at a very high cost developing and result in permanent complications, including lower IQ, slower processing speed, as well social problems lifelong dependency. Lithium has...
Abstract BACKGROUND Radiotherapy remains a cornerstone of the treatment high-grade brain tumors. However, while lifesaving, it results in long-term complications 50-96 % treated individuals, where cognitive deficits are particularly debilitating. Currently, no treatments or preventive strategies available to avert these deficits. Lithium (Li), long used treat bipolar affective disorder, has been shown reduce radiation-induced rodent models by preventing apoptosis neuronal stem and progenitor...
Abstract Cranial irradiation (IR) is one of the pillars treatment brain tumors and metastases, but it causes progressive neurocognitive impairments in cancer survivors. Neuroinflammation believed to contribute this, its dynamics consequences on function remain poorly understood. Here, we performed longitudinal molecular cellular profiling irradiated mouse hippocampus, a key structure for cognitive tasks, using single cell transcriptomics computational analyses, proteomics histology, covering...
Cranial radiotherapy can cause lifelong cognitive complications in childhood brain tumor survivors, and reduced hippocampal neurogenesis is hypothesized to contribute this. Following irradiation (IR), microglia clear dead neural progenitors give rise a neuroinflammatory microenvironment, which promotes switch surviving from neuronal glial differentiation. Recently, depletion repopulation of were shown promote ameliorate deficits various injury models. In this study, we utilized the...
Introduction. Neoplasms of the choroid plexus tumors are neuroectodermal origin corresponding to 0.4% 0.6% brain tumors. In vast majority benign with a predilection for cerebral ventricles as local appearance. Objective. To report case child under 3 years age and carcinoma. Method. Case patient Results. The underwent surgery subsequent radiotherapy at moment, an outpatient. Conclusion. Although most common in children 2 carcinoma can occur older patients remain asymptomatic until it...
ABSTRACT Background: Autoimmune enteropathy is normally characterised by crypt hyperplastic villous atrophy with enterocyte autoantibodies, activation of mucosal lymphocytes and increased epithelial HLA‐DR. This case involved a severely affected Portuguese infant who was found to have lymphocyte deficiency demonstrated correspondingly distinct features. Methods: A female nonconsanguineous parents treated for vomiting diarrhoea, first milk exclusion then parenteral nutrition. Lymphocyte...
Background Although evidence has emerged indicating that patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia present a high risk of venous thromboembolism (VTE), its real incidence and best diagnosis course remain unclear. In this study, we aimed to determine the pulmonary embolism in these role D-dimer serum level as predictive factor new VTE event. Methodology This was single-center retrospective observational cohort study conducted tertiary hospital. All...
Abstract Tumors are dynamic entities that act like organs in a perfect trading with the entire body. Through employment of deceiving cellular and molecular strategies, they use corporal machinery for promotion their survival dissemination. The extensive crosstalk mediated by cytokines chemokines overcome inefficiency invasion-metastasis cascade, thus allowing development often fatal metastatic disease. As heterogeneous entities, tumors comprised distinct cell populations. Cancer stem cells...