A5077293613- Marine Toxins and Detection Methods
- Nicotinic Acetylcholine Receptors Study
- Ion channel regulation and function
- Mast cells and histamine
- Neuroscience and Neuropharmacology Research
- Marine and coastal ecosystems
- Mycotoxins in Agriculture and Food
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Marine Biology and Environmental Chemistry
- Marine Sponges and Natural Products
- Neuroscience of respiration and sleep
- Environmental Chemistry and Analysis
- Cholinesterase and Neurodegenerative Diseases
- Environmental Toxicology and Ecotoxicology
- Receptor Mechanisms and Signaling
- Protist diversity and phylogeny
- Signaling Pathways in Disease
- Aquatic Ecosystems and Phytoplankton Dynamics
- Chemical synthesis and alkaloids
- Animal Ecology and Behavior Studies
- Polyamine Metabolism and Applications
- Nitric Oxide and Endothelin Effects
- Forensic Toxicology and Drug Analysis
- Neuroinflammation and Neurodegeneration Mechanisms
Universidade de Santiago de Compostela
2016-2025
Instituto de Investigación Sanitaria de Santiago
2021
Society of Environmental Toxicology and Chemistry
2018
Pondicherry University
2018
University of the Basque Country
2014-2016
Donostia International Physics Center
2015-2016
Universidade de Vigo
1988-2016
Ayuntamiento de San Sebastián
2016
Tohoku University
2004-2014
Rede de Química e Tecnologia
2014
The gene product of the steel locus mouse represents a growth factor for murine mast cells and ligand c-kit proto-oncogene receptor, member tyrosine kinase receptor class oncogenes (for review, see O. N. Witte. 1990. Cell 63:5). We have studied effect human recombinant stem cell (rhSCF) on release inflammatory mediators from skin peripheral blood basophils compared its activity to that rhIL-3, rhSCF (1 ng/ml 1 microgram/ml) activated histamine PGD2 isolated skin. Analysis by digital video...
Tetrodotoxin (TTX) is one of the most potent toxins already isolated, which occurs in a wide variety animals. In this work, occurrence TTX and analogues was examined using mass spectrometry, confocal microscopy, liquid chromatography−mass spectrometry (LC−MS), mouse bioassay trumpet shell (Charonia lampas lampas) fluids patient poisoned by consuming shell. Retention time data LC−MS system within enhanced spectrum (EMS) mode indicated presence analogue 5,6,11-trideoxyTTX; product ion (EPI)...
Tetrodotoxin (TTX) and its analogues are produced by marine bacteria have been detected in bivalves gastropods from European waters. The Commission asked EFSA for a scientific opinion on the risks to public health related presence of TTX gastropods. Panel Contaminants Food Chain reviewed available literature but did not find support minimum lethal dose humans 2 mg, mentioned various reviews. Some human case reports describe serious effects at 0.2 corresponding 4 μg/kg body weight (bw)....
During official shellfish control for the presence of marine biotoxins in Greece year 2012, a series unexplained positive mouse bioassays (MBA) lipophilic toxins with nervous symptomatology prior to mice death was observed mussels from Vistonikos Bay-Lagos, Rodopi. This atypical toxicity coincided (a) absence or low levels regulated and some non-regulated (b) simultaneous potentially toxic microalgal species Prorocentrum minimum at up 1.89 × 103 cells/L area's seawater. Further analyses by...
With laboratories seeking to expand analytical capabilities and create multi-class, multi-analyte methods, there has been a shift toward generic sample clean-up techniques such as "dilute-and-shoot". Advantages of this methodology include its simplicity, minimal analyte losses, high throughput number classes included. The evolution dilute-and-shoot permitted use across variety matrices including food biological in various scientific fields food, forensics environmental. versatility the...
Ciguatera fish poisoning (CFP) is a human foodborne intoxication caused by ingestion of tropical fishes contaminated with the potent polyether toxins known as ciguatoxins (CTXs). These are issued from Gambierdiscus species dinoflagellates. Herbivorous accumulate these in their musculature and viscera after ingesting Epidemiological studies showed that CFP has been present areas between 35 degrees North South latitude, mainly, Indo-pacific Caribbean areas, but not waters closed to European...
The detection of paralytic shellfish poisoning (PSP) toxins in contaminated is essential for human health preservation. Ethical and technical reasons have prompted the search new procedures as an alternative to mouse bioassay. On basis molecular interactions by surface plasmon resonance (SPR) biosensors, inhibition assay was developed using anti-GTX2/3 antibody (GT13-A) a saxitoxin-CM5 chip. This allowed quantification saxitoxin (STX), decarbamoyl (dcSTX), gonyautoxin 2,3 (GTX2/3),...
Tetrodotoxin is a potent low weight marine toxin found in warm waters, especially of the Indian and Pacific Oceans. Intoxications are usually linked to consumption puffer fish, although TTX was already detected several different edible taxa. Benthic organisms such as mollusks echinoderms, with feeding habits, were collected monthly along Portuguese coast from summer 2009 until end 2010. The extraction analysis techniques optimized some analogues for first time two intertidal gastropod...
A multistimuli response to temperature and pressure is found in the hybrid inorganic–organic perovskite-like [TPrA][Mn(dca)3] compound, which related a first-order structural phase transition near room temperature, Tt ≈ 330 K. This involves transformation from polymorph I, with noncentrosymmetric space group P4̅21c, high II, centrosymmetric I4/mcm, it implies ionic displacements, order–disorder phenomena, large anisotropic thermal expansion (specially along c-axis). As consequence, exhibits...
In recent years, our group and several others have been describing the presence of new, not previously reported, toxins high toxicity in vectors that may reach human food chain. These include tetrodotoxin gastropods South Europe, ciguatoxin fish Spain, palytoxin mussels Mediterranean Sea, pinnatoxin all over okadaic acid south U.S. There seem to be new marine appearing areas are heavy producers seafood, this is a cause concern as most these included current legislation monitoring programs....
A new natural product named gambierone (1) was isolated from the cultured dinoflagellate Gambierdiscus belizeanus. The structure of this compound features an unprecedented polyether skeleton and unusual right-hand side chain. Its relative configuration fully determined by interpretation ROESY experiment comparison between experimental theoretical NMR data. Although succession cycles has no chemical similarity with ciguatoxins, 1 a molecular formula biological activity similar to those...
The hybrids [TPrA][M(dca)<sub>3</sub>] (M: Fe<sup>2+</sup>, Co<sup>2+</sup> and Ni<sup>2+</sup>) are unique multi-sensitive materials that display multiple phase dielectric transitions.