A5100402566- Knee injuries and reconstruction techniques
- Total Knee Arthroplasty Outcomes
- Shoulder Injury and Treatment
- Sports injuries and prevention
- Tendon Structure and Treatment
- Shoulder and Clavicle Injuries
- Osteoarthritis Treatment and Mechanisms
- Lower Extremity Biomechanics and Pathologies
- Orthopaedic implants and arthroplasty
- Orthopedic Surgery and Rehabilitation
- Bone Tissue Engineering Materials
- Bone fractures and treatments
- Musculoskeletal synovial abnormalities and treatments
- Spine and Intervertebral Disc Pathology
- Prenatal Screening and Diagnostics
- Hip disorders and treatments
- Orthopedic Infections and Treatments
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hemoglobinopathies and Related Disorders
- Venous Thromboembolism Diagnosis and Management
- Spinal Fractures and Fixation Techniques
- Temporomandibular Joint Disorders
- Birth, Development, and Health
- Bone health and osteoporosis research
West China Hospital of Sichuan University
2016-2025
Sichuan University
2016-2025
Yanbian University
2025
Huazhong University of Science and Technology
2011-2025
Yanshan University
2025
Tongji Hospital
2011-2025
Dalian University
2022-2025
City University of Hong Kong
2024
Tianjin Hospital
2018-2024
Tianjin University
2018-2024
Abstract The use of large language models (LLMs) in clinical medicine is currently thriving. Effectively transferring LLMs’ pertinent theoretical knowledge from computer science to their application crucial. Prompt engineering has shown potential as an effective method this regard. To explore the prompt LLMs and examine reliability LLMs, different styles prompts were designed used ask about agreement with American Academy Orthopedic Surgeons (AAOS) osteoarthritis (OA) evidence-based...
Abstract Due to the inherent aseptic and enclosed characteristics of joint cavity, septic arthritis (SA) almost inevitably leads intractable infections rapidly progressing complex pathological environments. Presently, SA faces not only deficient effectiveness gold‐standard systemic antibiotic therapy but also scarcity effective localized targeted approaches standardized animal models. Herein, an ingenious multifunctional nanosystem is designed, which involves methylation hyaluronic acid...
Abstract The large majority of structural MRI studies major depressive disorder (MDD) investigated volumetric changes in chronic medicated patients whom course illness and treatment effects may impact anatomic measurements. Further, few studies, separate measurements cortical thickness surface area have been performed that reflect different neurobiological processes regulated by genetic mechanisms. In the present study, we both first-episode, treatment-naïve, mid-life MDD to elucidate core...
Objective To evaluate the clinical outcomes of high‐intensity focused ultrasound ( HIFU ) and surgery in treating uterine fibroids, prepare for a definitive randomised trial. Design Prospective multicentre patient choice cohort study IDEAL Exploratory study) , myomectomy or hysterectomy symptomatic fibroids. Setting 20 Chinese hospitals. Population sample 2411 women with Methods non‐randomised learning curve analysis Stage 2b Exploration Study). Main outcome measures Complications, hospital...
Background: Many shortcomings exist in the traditional methods of treating bone defects, such as donor tissue shortages for autografts and disease transmission allografts. The objective this study was to design a novel three-dimensional nanostructured substitute based on magnetically synthesized single-walled carbon nanotubes (SWCNT), biomimetic hydrothermally treated nanocrystalline hydroxyapatite, biocompatible hydrogel (chitosan). Both hydroxyapatite SWCNT have nanostructure, excellent...
After 480 days of age, high-producing hens are likely to be subject ovarian aging, mainly due oxidative stress. In this study, the amelioration aging in chickens, using a plant antioxidant, lycopene, was investigated. The activity Nrf2/HO-1 pathway chicken ovaries at different ages (90, 150, 280 and 580 old) were compared elucidate any age-related changes. Subsequently, putative attenuating effect lycopene (100 ng/mL) on evaluated through establishment D-gal-induced culture model. cultured...
Significance Chromosomal aneuploidies represent a major cause of fetal loss and birth defects. Current methods for the prenatal diagnosis aneuploidy require invasive that are associated with risk miscarriage other complications. Recently, noninvasive testing has been developed using cell-free DNA in maternal plasma. In this study, we validated an effective method semiconductor sequencer, which reduces time cost sequencing. Our is cost-effective practical clinical setting high sensitivity...
Bone defect repairs are based on bone graft fusion or replacement. Current large treatments inadequate and lack of reliable technology. Therefore, we aimed to investigate a simple technique using three-dimensional (3D)-printed individualized porous implants without any grafts, osteoinductive agents, surface biofunctionalization treat defects, systematically study its long-term therapeutic effects osseointegration characteristics. Twenty-six patients with defects caused by tumor, infection,...
The efficacy of large language models (LLMs) in domain-specific medicine, particularly for managing complex diseases such as osteoarthritis (OA), remains largely unexplored.
Abstract Background The bone holes in the skull during surgical drainage were accurately located at site of MMA. MMA was severed, and hematoma removed intraoperatively; furthermore, pathogenic factors CSDH. This study aimed to describe compare results new treatment with those traditional drainage, investigate relevance this approach. Methods From December 2021 June 2023, 72 patients randomly assigned observation group control group. treated while DSA imaging locate drilled on trunk before...
Background Rotator cuff tears are common, affecting more than 60% of individuals older 80 years, and they have been implicated in 70% patients with shoulder pain. M1 polarization-related inflammation has reported to be associated poor healing outcomes rotator injury, leptin, an adipokine, a potential activator inflammation. However, whether leptin affects repair remains unknown. Questions/purposes Using vitro cell experiments vivo rat tear model, we therefore asked: (1) Does promote the...
Background: The effect of lateral meniscal posterior root tear and repair—commonly seen in clinical practice the setting anterior cruciate ligament (ACL) reconstruction—is not known. Purpose/Hypothesis: This study evaluated repair on biomechanics ACL-reconstructed knee. It was hypothesized that tibial translation would increase under loading simulated pivot-shift with meniscus, while reduce it close to noninjured state. Study Design: Controlled laboratory study. Methods: Thirteen...
Can a core outcome set to standardize selection, collection and reporting across future infertility research be developed?A minimum data set, known as has been developed for randomized controlled trials (RCTs) systematic reviews evaluating potential treatments infertility.Complex issues, including failure consider the perspectives of people with fertility problems when selecting outcomes, variations in definitions selective outcomes on basis statistical analysis, make results difficult...
Musculoskeletal tissue degeneration impairs the life quality and motor function of many people, especially seniors athletes. Tendinopathy is one most common diseases associated with musculoskeletal degeneration, representing a major global healthcare burden that affects both athletes general population, clinical presentation long-term recurring chronic pain decreased tolerance to activity. The cellular molecular mechanisms at basis disease process remain elusive. Here, we use single-cell...
Monitoring cell profiles in 3D porous scaffolds presents a major challenge tissue engineering. In this study, we investigate optical coherence tomography (OCT) as an imaging modality to monitor non-invasively both structures and cells engineered constructs. We employ time-domain OCT visualize macro-structural morphology, whole-field microscopy delineate the morphology of constructs developing vitro bone tissue. The results show great potential for use non-invasive monitoring cellular...
Discoid lateral meniscus (DLM) is the most common congenital variant of meniscus, which prone to degeneration and lesions, often leads knee osteoarthritis. At present, there no consensus on clinical practice DLM, this expert guidelines DLM was developed approved by Chinese Society Sports Medicine according Delphi method. Among 32 statements drafted, 14 were excluded for redundant information, 18 achieved consensus. This focused definition, epidemiology, etiology, classification,...