Sepsis-associated acute kidney injury (S-AKI) is a common complication in hospitalized and critically ill patients, which increases the risk of multiple comorbidities associated with extremely high mortality. Maresin 1 (MaR1), lipid mediator derived from omega-3 fatty acid docosahexaenoic has been reported to protect against inflammation promote regression inflammation. This study proposed systematically investigate renoprotective effects potential molecular mechanism MaR1 septic injury. We...

Rationale: Sepsis is a severe clinical syndrome featured through organ dysfunction due to infection, while the accompanying acute kidney injury (AKI) linked significant incidence of morbidity as well mortality. Recently, emerging evidence has revealed that nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 (NOX4) implicated in various renal diseases, its role and modulation septic (S-AKI) remains largely unknown. Methods:In vivo, S-AKI wild-type tubular epithelial cell...

Abstract Aim Severe acute pancreatitis ( SAP ) is believed to be a major risk factor leading kidney injury AKI among critically ill patients, but little known about ‐induced . We study the incidence of defined by A cute K idney I njury N etwork AKIN criteria and factors associated with outcomes patients. Method conducted multicenter retrospective patients during period ugust 2009 J une 2013. Data on enrolled were retrieved from electronic records. Univariate multiple regression analyses...

Sepsis/septic shock-associated acute kidney injury (S-AKI) is associated with prolonged recovery and extremely high mortality. Extracorporeal blood purification therapy for the removal of endotoxin cytokines might benefit patients S-AKI. The purpose this study was to compare efficacy adsorbing filter oXiris in treatment

ABSTRACT Background The application of high cutoff (HCO) membranes for continuous renal replacement therapy remains unclear in septic acute kidney injury (S‐AKI) patients. Methods S‐AKI patients who received veno‐venous hemodiafiltration (CVVHDF) were randomly assigned to the experimental group (HCO membrane) and control (high flux membrane, HF membrane). Interleukin‐6 (IL‐6) tumor necrosis factor‐α (TNF‐α) serum waste fluid measured at 0, 2, 12, 24 h after CVVHDF initiation 28‐day...

Optic neuritis (ON) is an inflammatory optic neuropathy characterized by acute vision loss. Primary anti-PLA2R-positive membranous nephropathy, autoimmune disease, has been reported to be related neurological diseases. However, the co-occurrence of ON and primary nephropathy (PMN) not reported. A 57-year-old male presented with bilateral Laboratory tests indicated proteinuria, hypoalbuminemia, hyperlipidemia, a significantly increased level anti-phospholipase A2 receptor antibody (PLA2RAb)....

Mercury intoxication is not uncommon and often presents with diverse symptoms of multiple systems. While neurological disorders renal impairments have been examined in isolation, the concurrent occurrence systemic linked to immune dysregulation infrequently observed. Here, we report an unusual case that a 55-year-old male patient, who scrap merchant, was admitted our center for neuropsychiatric disturbances, including incoherent speech hallucinations. He initially diagnosed autoimmune...

<title>Abstract</title> <bold>Background </bold>Atypical anti-GBM nephritis with Henoch-Schönlein purpura (HSPN) is a rare immune-mediated kidney disease that usually manifests as an immune response to the glomerular basement membrane (GBM). Unlike typical nephritis, serum antibodies may be negative despite similar clinical symptoms and renal damage. <bold>Case </bold>We reported 16-year-old woman hematuria, proteinuria, rash, antibody. Renal biopsy showed segmental glomerulosclerosis...

<title>Abstract</title> The full text of this preprint has been withdrawn by the authors as it was submitted and made public without consent all authors. Therefore, do not wish work to be cited a reference. Questions should directed corresponding author.

Summary Background and objective To observe the outcomes of AKI following multiple wasp stings. Design, setting, participants, &amp; measurements Eighty-one patients (mean age ± SD, 45.5±14.7 years; 55 men 26 women; mean Acute Physiology Chronic Health Evaluation II score, 16.85±2.78) with stings between 1997 2011 were retrospectively analyzed. Data on their demographic characteristics, initial modalities renal replacement therapy (RRT), urine output, serum creatinine, bilirubin, myoglobin,...

Mechanical ventilation (MV) is a life-supporting modality frequently performed in critically ill patients to mechanically assist or replace spontaneous breathing. The aim of this study was investigate the effect hypophosphatemia on withdrawal MV with acute exacerbations chronic obstructive pulmonary disease (AECOPD). medical records 67 AECOPD cases, treated between 2011 and 2013, were analyzed retrospectively. assigned hypophosphatemic normophosphatemic groups according their serum phosphate...

Resolvin D1 (RvD1) is a newly found anti-inflammatory bioactive compound derived from polyunsaturated fatty acids. The current study aimed to explore the protective effect of RvD1 on lipopolysaccharide (LPS)-induced acute kidney injury (AKI) and its possible mechanism.Both in vivo vitro studies were conducted. Male BALB/c mice randomly divided into control group (saline), LPS (LPS 5 mg/kg), (RvD1 μg/kg + blockage (Boc-MLP mg/kg). Boc-MLP receptor blocker. intraperitoneally injected with...

Abstract Introduction: There is no consensus on the specific indications for weaning critically ill patients with acute kidney injury (AKI) off renal replacement therapy (RRT). This study aimed to explore prognostic value of several biomarkers measured upon discontinuation RRT their in predicting 60‐day survival and recovery an effort add knowledge decision‐making process regarding withdrawal. Methods: We prospectively enrolled 102 AKI who required from intensive care unit. Serum osteopontin...

M-type phospholipase A2 receptor (PLA2R) is known as a major antigen on podocytes, which involved with the pathogenesis of idiopathic membranous nephropathy (iMN). Many studies have shown that serum anti-PLA2R autoantibodies (sPLA2R) are prevalent in patients iMN but rarely detected secondary (SMN) or other glomerulonephritis. The considered promising biomarker reports about its diagnostic value variable and inconsistent.To evaluate test accuracy (DTA) glomerular PLA2R (gPLA2R) for...

Acute kidney injury (AKI) caused by bee stings is common, with characteristics of acute onset, severe illness, and high mortality. Melittin, a major component venom, has been considered to play key role in sting related AKI. This study aims illustrate whether melittin could lead apoptosis renal tubular epithelial cells (RTECs) investigate its mechanism.In vivo, 45 mice were randomly divided into the group (n=30, injected tail vein according total dose 4.0 ug/g weight) control (n=15, same...

Abstract Background The present research aims to investigate the clinical diagnostic value of LncRNA HOXA distal transcript antisense RNA (HOTTIP) in acute respiratory distress syndrome (ARDS) sepsis and its predictive significance for mortality. Methods One hundred eighteenth patients with 96 healthy individuals were enrolled. RT-qPCR examine HOTTIP levels. incidence ARDS death was recorded. examined using ROC logistic regression analysis. correlation between disease severity evaluated...

Hemodialysis catheter-related superior vena cava (SVC) occlusions can cause considerable morbidity for patients and be challenging to treat if refractory conventional guide wire transversal. This pilot study assessed the feasibility safety of sharp recanalization SVC occlusion in hemodialysis patients.This retrospectively enrolled treated West China Hospital diagnosed with who failed traditional transversal from January 2014 November 2017. In brief, a femoral approach was advanced lower end...