A5032226376- Acute Kidney Injury Research
- Dialysis and Renal Disease Management
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Chronic Kidney Disease and Diabetes
- Sepsis Diagnosis and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Systemic Sclerosis and Related Diseases
- S100 Proteins and Annexins
- Pharmacovigilance and Adverse Drug Reactions
- Sleep and Work-Related Fatigue
- Liver Disease Diagnosis and Treatment
- Aortic Thrombus and Embolism
- Sleep and related disorders
- COVID-19 and healthcare impacts
- RNA regulation and disease
- Inflammasome and immune disorders
- Vitamin D Research Studies
- Biomedical Text Mining and Ontologies
- Pharmacological Effects and Toxicity Studies
- Long-Term Effects of COVID-19
- Hemodynamic Monitoring and Therapy
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiac Ischemia and Reperfusion
Jiujiang First People's Hospital
2021-2024
West China Hospital of Sichuan University
2021-2022
Sichuan University
2021-2022
Sichuan Research Center of New Materials
2021-2022
Wuhan University
2017
Wuhan No.1 Hospital
2017
Sepsis-associated acute kidney injury (S-AKI) is a common complication in hospitalized and critically ill patients, which increases the risk of multiple comorbidities associated with extremely high mortality. Maresin 1 (MaR1), lipid mediator derived from omega-3 fatty acid docosahexaenoic has been reported to protect against inflammation promote regression inflammation. This study proposed systematically investigate renoprotective effects potential molecular mechanism MaR1 septic injury. We...
Rationale: Sepsis is a severe clinical syndrome featured through organ dysfunction due to infection, while the accompanying acute kidney injury (AKI) linked significant incidence of morbidity as well mortality. Recently, emerging evidence has revealed that nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 (NOX4) implicated in various renal diseases, its role and modulation septic (S-AKI) remains largely unknown. Methods:In vivo, S-AKI wild-type tubular epithelial cell...
The negative effects of visceral adiposity accumulation on cardiovascular health have drawn much attention. However, the association between Visceral Adiposity Index (VAI) and Abdominal Aortic Calcification (AAC) has never been reported before. authors aimed to investigate VAI AAC in US adults.Cross-sectional data were derived from 2013 2014 National Health Nutrition Examination Survey (NHANES) participants with complete scores. Weighted multivariable regression logistic analysis conducted...
We aimed to investigate the association of visceral adiposity index (VAI) with decreased renal function in US adults.Cross-sectional data were analyzed for 35,018 adults National Health and Nutrition Examination Survey (NHANES) 2005-2018. VAI was determined using waist circumference, body mass (BMI), triglycerides (TGs) high-density lipoprotein-cholesterol. Albuminuria defined as urinary albumin-to-creatinine ratio (ACR) >30 mg/g. A low estimated-glomerular filtration rate (eGFR) an eGFR...
Aims: We aimed to assess the association between dietary inflammation index (DII) and abdominal aortic calcification (AAC) in US adults aged ≥40 years. Methods: Data were obtained from 2013–2014 National Health Nutrition Examination Survey (NHANES). Participants who <40 years old missing data of DII AAC excluded. was calculated based on a 24-h recall interview for each participant. score quantified by assessing lateral spine images severe defined as >6. Weighted multivariable...
Vascular calcification is commonly observed in chronic kidney disease. The mechanism of how the signal from endothelial cells transmitted to vascular smooth muscle (VSMCs) remains unknown. aim present study was investigate whether exosomes HUVECs (HUVEC‑Exos) could regulate VSMC and its potential signaling pathway. HUVEC‑Exos were isolated under no phosphorus (NP) high (HP) conditions. Alizarin Red S staining calcium (Ca) content analysis carried out detect VSMCs. Proteomics differential...
Background: Anticoagulation is generally used in hospitalized patients with coronavirus disease 2019 (COVID-19) as thromboprophylaxis. However, results from different studies comparing the effect of anticoagulation on mortality COVID-19 non-anticoagulation are inconclusive. Methods: Our systematic review included observational trials if they studied anticoagulant therapy for or bleeding events. Dichotomous variables individual were pooled by risk ratio (RR) and their 95% confidence interval...
Aims This study aimed to assess the relationship between dietary inflammatory index (DII) and sex hormones in male children adolescents aged 6-19 years. Methods We obtained data from 2013-2016 National Health Nutrition Examination Survey (NHANES). Male participants years old with complete of DII were included. Weighted multiple regression analysis subgroup preformed estimate independent hormones. Results A total 1717 average age 13.02 ± 3.82 enrolled, whom 41.3% (n=713) 58.47% (n=1004)...
Short and long sleep durations have been associated with adverse health outcomes. The objective of this study was to examine the association between self-reported duration chronic kidney disease (CKD) in general population on basis National Health Nutrition Examination Survey (NHANES) database.A total 28,239 adults aged ≥18 years who participated 2005-2014 NHANES were analyzed. CKD defined as an estimated glomerular filtration rate <60 mL/min per 1.73 m2 or urinary albumin/urine...
Acute kidney injury is a highly common and multifactorial renal disease resulting in significant morbidity mortality, especially sepsis-induced acute injury. There no effective therapy available to treat or prevent One of the specialized pro-resolving mediators, Resolvin D1 exhibits special anti-inflammatory effects several inflammatory models, but there little evidence about effect mechanism injury.We conducted experiments explore In vitro, human proximal tubular epithelial cells were used...
Lupus nephritis (LN) is a highly prevalent complication of systemic lupus erythematosus (SLE). Long non-coding RNAs (lncRNAs) are essential modulators in multiple types human diseases, including LN. In the current study, we searched on online GEO database to select out lncRNAs that were differentially expressed blood samples LN patients. Through further RT-qPCR analysis, found lncRNA Highly Accelerated Region 1 A (HAR1A) most significantly upregulated Functionally, detected overexpression...
Although many molecular studies have tried to explore the relationship between vitamin D metabolism and kidney function, association 25-hydroxyvitamin [25(OH)D] function is still controversial. Previous reported that low status decreased were associated with insulin resistance (IR). However, neither of them was confirmed by large population-based studies. This study evaluated associations 25(OH)D both IR among adults in United States America (USA).We analyzed 36,523 from National Health...
Abstract BACKGROUND AND AIMS Circulating histones play a crucial role in the development and progression of sepsis is associated with high mortality. Hemadsorption CytoSorb® filter has been shown to non-specifically eliminate systemic circulating plasma from injured patients ex vivo vitro. The aim this study was fabricate another novel hemoperfusion adsorbent for selective removal blood septic patients. METHOD Chitosan-cellulose composite hydrogels (CSCE) were first prepared using...
With the fast development of big data, we can do better in modern digital health.The rational use drugs is main threat medication security.With data mining, analyze drug instructions to automatically detect adverse interaction combination.The proposed method synthetically employs NLP and complex network construct ingredient for mining inference combination.First, many are collected by crawler from professional medicine websites.Next, utilized extract effective building library.Then,...
Abstract BACKGROUND AND AIMS Vascular calcification can occur in the early stages of chronic kidney disease (CKD) and result a poor prognosis. How signal blood is transduced from endothelial cells tunica intima to vascular smooth muscle media CKD still unknown. The aim this study was explore role exosomes transduction calcification. METHOD Exosomes were isolated normal phosphate- high phosphate-stimulated human umbilical vein (HUVECs) by superspeed centrifugation. We used transmission...