A5101804481- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Lung Cancer Treatments and Mutations
- Head and Neck Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Crystallography and molecular interactions
- Urticaria and Related Conditions
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastric Cancer Management and Outcomes
- Diabetes Treatment and Management
- Spine and Intervertebral Disc Pathology
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Autoimmune Bullous Skin Diseases
- Gallbladder and Bile Duct Disorders
- Lung Cancer Diagnosis and Treatment
- Multiple and Secondary Primary Cancers
- Corneal surgery and disorders
- Advanced Neuroimaging Techniques and Applications
- Ocular Surface and Contact Lens
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Corneal Surgery and Treatments
- Metabolism, Diabetes, and Cancer
- Ocular Infections and Treatments
- Dialysis and Renal Disease Management
Merck & Co., Inc., Rahway, NJ, USA (United States)
2022-2025
Women's Hospital, School of Medicine, Zhejiang University
2024
Qingdao Women and Children's Hospital
2023
Qingdao University
2023
Southern Medical University
2022-2023
ShenZhen People’s Hospital
2023
Sichuan University
2011-2022
West China Hospital of Sichuan University
2019-2022
Bengbu Medical College
2022
First People's Hospital of Chongqing
2022
Overcoming resistance to chemotherapy is a major and unmet medical challenge in the treatment of pancreatic cancer. Poor drug delivery due stromal barriers tumor microenvironment aggressive biology are additional impediments toward more successful In attempts address these challenges, we developed IGF1 receptor (IGF1R)-directed, multifunctional theranostic nanoparticles for targeted therapeutic agents into IGF1R-expressing drug-resistant cells tumor-associated cells. These were prepared by...
Abstract Background For the treatment of low back pain, following three scenarios posterior lumbar interbody fusion (PLIF) were usually used, i.e., PLIF procedure with autogenous iliac bone (PAIB model), cages made PEEK (PCP model) or titanium (Ti) (PCT materiel. But benefits adverse effects among surgical still not fully understood. Method Finite element analysis (FEA), as an efficient tool for diseases, was used to establish a three-dimensional nonlinear L1-S1 FE model (intact ligaments...
345 Background: Treatment options for patients with early-stage GC/GEJC are still limited and the prognosis remains poor, despite recent therapy approvals. With latest adoption of FLOT use in US, it is important to understand patients’ characteristics, treatment patterns outcomes US community oncology setting. Methods: This retrospective observational cohort study used electronic health records data from 278 adult stage II-IVA adenocarcinoma initiating neoadjuvant (index) within The Oncology...
The programmed death-1 (PD-1) immune checkpoint inhibitor pembrolizumab is currently approved in the US for first-line (1L) treatment of recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC), either alone combination with platinum 5-fluorouracil (5-FU). However, toxicity 5-FU has motivated study alternate combinations that replace a taxane. objective current was to describe baseline characteristics, patterns sequences, real-world outcomes individuals receiving + taxane as...
Abstract Objectives: The cerebellum (CB) is known for its role in supporting processing speed (PS) and cognitive efficiencies. CB often sustains damage from treatment resection pediatric patients with posterior fossa tumors. Limited research suggests that atrophy may be associated the radiation experienced during childhood. purpose of study was to measure cerebellar determine neurobehavioral correlates. Methods: Brain magnetic resonance images were collected 25 adult survivors tumors age-...
Impact of lung function on exacerbations, health care utilization, and costs among patients with COPD Xuehua Ke,1 Jessica Marvel,2 Tzy-Chyi Yu,2 Debra Wertz,1 Caroline Geremakis,1 Liya Wang,1 Judith J Stephenson,1 David M Mannino3 1HealthCore Inc., Wilmington, DE, 2Novartis Pharmaceuticals Corporation, East Hanover, NJ, 3University Kentucky, Lexington, KY, USA Objective: To evaluate the impact function, measured as forced expiratory volume in 1 second (FEV1) % predicted, resource utilization...
Pembrolizumab, a PD-1 immune checkpoint inhibitor, is approved as first-line (1L) treatment for recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) monotherapy in combination with platinum 5-fluorouracil chemotherapy. Limited data exist on the use of these regimens real-world settings.Our primary objectives were to describe baseline characteristics overall survival (rwOS), time (rwToT), next (rwTTNT) among individuals R/M HNSCC receiving 1L pembrolizumab therapies. We...
This paper establishes a non-linear finite element model (NFEM) of L4-L5 lumbar spinal segment with accurate three-dimensional solid ligaments and intervertebral disc. For the purpose, disc surrounding are modeled four-nodal tetrahedral elements hyper-elastic material properties. Pure moment 10 N·m without preload is applied to upper vertebral body under loading conditions lateral bending, backward extension, torsion, forward flexion, respectively. The simulate relationship curves between...
Aim: Study first-line (1L) treatment patterns and economic outcomes among patients with advanced metastatic gastric cancer (GC) esophageal (EC). Materials & methods: Newly diagnosed systemic GC EC treatments were identified between 1 January 2011 31 July 2017; costs presented as per patient month (PPPM) basis. Results: included 392 436 patients. Most frequently used 1L regimens were: 5-fluorouracil (5-FU) + oxaliplatin (22.5%) epirubicin cisplatin 5-FU (ECF)/ECF modifications (21.9%) in GC;...
To report 1-year clinical and economic outcomes from the retrospective DISPEL (Dulaglutide vs Basal InSulin in Injection Naïve Patients with Type 2 Diabetes: Effectiveness ReaL World) Study.This observational claims study included patients type diabetes (T2D) ≥1 claim for dulaglutide or basal insulin between November 2014 April 2017 (index date=earliest fill date). Propensity score matching was used to address treatment selection bias. Change baseline hemoglobin A1c (HbA1c) compared matched...
Several studies have demonstrated that exercise preconditioning is an effective means of alleviating poststroke cognitive impairment (PSCI). Mechanisms regulating function not been fully elucidated. Herein, the present study aimed at exploring effect microbiota-gut-inflammasome-brain axis in process moderating after ischemic stroke. We observed decreased infarct size, reduced degree neuronal damage, and alleviated mice with In addition, also expression inflammatory cytokines, as well NLRP3,...
To examine treatment patterns, response, and demographic clinical characteristics of patients with chronic idiopathic urticaria (CIU) newly initiated on omalizumab therapy in real-world practice the US.This retrospective observational cohort study used US claims data from HealthCore Integrated Research Database (HIRD®) augmented medical record to identify CIU newly-treated (≥4 within 6 months initial claim; index date = first claim date) between March 21, 2014 October 31, 2015 ≥6 pre- ≥12...
Introduction There is a need to understand the current treatment landscape for LA HNSCC in real-world setting. Methods This retrospective study assessed outcomes and patterns of 1,158 adult patients diagnosed with locally advanced (stage III-IVB) initiating chemoradiotherapy (CRT) within period January 2015 December 2017 large network US community oncology practices. Structured data were abstracted from electronic health records. Demographic, clinical characteristics analyzed descriptively...
Advances in cancer therapy have resulted more therapy-related cardiac dysfunction (CTRCD), which is the main cause of death older female survivors breast cancer. Traditionally, guideline-recommended medications for heart failure, such as beta-blockers and angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (ACEIs/ARBs), are commonly used to prevent or attenuate CTRCD. However, sometimes their effectiveness not satisfactory. Recently, drug combination sacubitril plus...
To analyze the age distribution of corneal disease in China by histopathological examination.A retrospective analysis prevalence and was performed on specimens from 3112 patients who underwent surgery between 2001 2012 Henan Eye Institute.Infectious keratitis (2212 specimens, 71.08%) most common disease. The groups significantly higher after 30 (16.29%), reaching a peak 40 (22.04%) remaining high until 59 (21.05%, P < 0.01). highest age-specific percentage infection ages 50 (83.21%,...
Omalizumab is indicated for the management of chronic idiopathic urticaria (CIU) in patients aged 12 years or older with persistent hives that are not adequately controlled by H1 antihistamines. While its safety and efficacy CIU have been evaluated multiple clinical trials, real-world use omalizaumab has well characterized.To assess demographics, characteristics, treatment patterns who initiated omalizumab to better understand usage this agent real world.This retrospective cohort study used...
Object: To establish a non-linear finite element (FE) model for human L4-L5 lumbar segment and verify its reliability. Method: A FE of was established. Some empirical expressions were used to simulate the mechanical properties vertebral body. The annulus fibrosus nucleus assigned hyper-elastic material. surrounding ligaments be unsymmetric spring elements. developed in ABAQUS software under loading conditions axial compression, lateral bending, extension, torsion, flexion. Result: result...
No AccessJournal of UrologyPediatric Urology1 Apr 2013Extracorporeal Shock Wave Lithotripsy is Effective in Treating Single Melamine Induced Urolithiasis Infants and Young Children Jianye Jia, Xiaowei Shen, Liya Wang, Tiejun Zhang, Maosheng Xu, Xiaoliang Fang, Guofeng Chen Qian, Yeming Wu, Hongquan Geng JiaJianye Jia Department Pediatric Urology, Xinhua Hospital, Shanghai Jiao tong University School Medicine Children's Treatment Center Chinese Ministry Health, Shanghai, China , ShenXiaowei...
Background The integration of data from disparate sources could help alleviate insufficiency in real-world studies and compensate for the inadequacies single short-duration, small sample size while improving utility research. Objective This study aims to describe evaluate a process integrating several complementary conduct health outcomes research patients with non–small cell lung cancer (NSCLC). integrated set is also used patient demographics, clinical characteristics, treatment patterns,...
Survival outcomes are related to treatment choices in a line of therapy and sequences across all lines therapy.The Real-World Treatment Sequences Outcomes among Patients with NSCLC (RESOUNDS) study is designed (1) evaluate used for patients who receive at least two non-small cell lung cancer (NSCLC) the United States (2) patient terms progression-free overall survival sequencing. Additional objectives include evaluation symptoms, comorbidities, health care resource utilization costs.Patients...
Omalizumab is indicated for the management of chronic idiopathic urticaria (CIU) in patients aged 12 years or older with persistent hives that are not adequately controlled by H1 antihistamines. While its safety and efficacy CIU have been evaluated multiple clinical trials, real-world use omalizaumab has well characterized.