A5101578358- Cancer, Hypoxia, and Metabolism
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Gallbladder and Bile Duct Disorders
- Glioma Diagnosis and Treatment
- Amino Acid Enzymes and Metabolism
- Epigenetics and DNA Methylation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA modifications and cancer
- Pancreatic and Hepatic Oncology Research
- Cancer-related molecular mechanisms research
- Medical Imaging Techniques and Applications
- Metabolism and Genetic Disorders
- Liver Disease Diagnosis and Treatment
- Ovarian function and disorders
- Cardiovascular Function and Risk Factors
- Cardiomyopathy and Myosin Studies
- Acute Ischemic Stroke Management
- Alzheimer's disease research and treatments
- Immune cells in cancer
- Cerebrovascular and Carotid Artery Diseases
- Osteoarthritis Treatment and Mechanisms
- Elbow and Forearm Trauma Treatment
- SARS-CoV-2 detection and testing
- Histone Deacetylase Inhibitors Research
Army Medical University
2021-2025
Emory University
2015-2025
Southwest Hospital
2022-2025
Northwest A&F University
2023-2024
Ministry of Agriculture and Rural Affairs
2023-2024
Shantou University
2023-2024
Cancer Hospital of Shantou University Medical College
2023-2024
DiscoveryBioMed (United States)
2024
Guangdong Province Women and Children Hospital
2023-2024
Guangzhou Medical University
2022-2024
Diet-derived nutrients are inextricably linked to human physiology by providing energy and biosynthetic building blocks functioning as regulatory molecules. However, the mechanisms which circulating in body influence specific physiological processes remain largely unknown. Here we use a blood nutrient compound library-based screening approach demonstrate that dietary trans-vaccenic acid (TVA) directly promotes effector CD8
Elevation in D-2-Hydroxyglutarate (D-2HG) has recently emerged as a mandatory byproduct of mutated Isocitrate Dehydrogenase (IDH) genes 1 and 2 glioma patients. The goal the present study was to demonstrate feasibility detection elevated levels D-2HG cerebrospinal fluid (CSF) patients that carry point substitutions IDH gene.We developed mass spectrometry (MS)-based platform detect quantify D- L-forms 2HG CSF Three independent cohorts were analyzed, comprising total 176 samples derived from...
Although tumor-associated macrophages (TAMs) have been shown to promote cancer progression, their roles in tumor development and resistance therapy remain be fully understood, mainly because of the lack a good approach evaluate dynamic changes heterogeneous residing microenvironment. Here, we report an using antibiofouling PEG-b-AGE polymer-coated iron oxide nanoparticles (IONPs) for targeted imaging mannose receptor (CD206)-expressing M2-like TAMs. Antibiofouling polymer coatings block...
Polycystic ovary syndrome (PCOS) is a set of endocrine disorder characterized by ovulation disorder. Increased insulin resistance (IR) and compensatory hyperinsulinemia play vital role in the pathogenesis PCOS. Therefore, sensitizing agents have been studied treatment Berberine (BBR) has proved to alleviate IR patients with PCOS, but mechanism remained unclear. This study was aimed verify regulatory BBR on PCOS-IR rats. Firstly, we established female rat model induced dehydroepiandrosterone...
Background and Purpose— Hypoperfusion-induced thrombosis is an important mechanism for postsurgery stroke cognitive decline, but there are no perioperative neuroprotectants to date. This study investigated whether prophylactic application of Edaravone, a free radical scavenger already used in treating ischemic Japan, can prevent infarct deficits murine model transient cerebral hypoxia-ischemia. Methods— Adult male C57BL/6 mice were subjected hypoxic-ischemic (tHI) insult that consists...
Background: The risk factors for biliary complications (BCs) after liver transplantation (LT) aren’t comprehensively determined. BCs also vary in times of onset. Machine learning (ML) can reveal regularities based on large-scale data to make predictions and have demonstrated good performance LT. However, whether ML be an efficient tool BC prediction wasn’t Methods: 517 patients from two centers were enrolled. Patients randomly divided into training validation sets at 3:1 ratio. K-fold...
Abstract The evolution of diet has played an essential role in shaping human physiology and pathology, including the development immune system responses to environmental stimuli. However, specific mechanisms underlying regulatory significance dietary components modulating anti-tumor immunity remain largely unknown. Here, we applied a co-culture screen approach using blood nutrient compound library identify zeaxanthin, carotenoid pigment found many fruits vegetables that is important for eye...
As the second most common non-melanoma skin cancer, cutaneous squamous cell carcinoma (cSCC) has experienced a significant increase in incidence. Although clinical detection is relatively easy, considerable number of patients are diagnosed at an advanced stage, featuring local tissue infiltration and distant metastasis. Cemiplimab, along with other immune checkpoint inhibitors, enhances T activation by blocking PD-1 pathway, resulting notable improvements outcomes. Nonetheless, approximately...
How altered metabolism contributes to chemotherapy resistance in cancer cells remains unclear. Through a metabolism-related kinome RNAi screen, we identified inositol-trisphosphate 3-kinase B (ITPKB) as critical enzyme that cisplatin-resistant tumor growth. We demonstrated inositol 1,3,4,5-tetrakisphosphate (IP4), the product of ITPKB, plays role redox homeostasis upon cisplatin exposure by reducing cisplatin-induced ROS through inhibition ROS-generating enzyme, NADPH oxidase 4 (NOX4), which...
Alzheimer's disease (AD) is a growing global healthcare burden affecting the aging population and society. Given lack of effective treatment to AD, early detection at prodromal stage timely monitoring changes during progression are considered best approach control intervene in progression. "Liquid biopsy" AD biomarkers amyloid-β peptides (Aβs) tau proteins cerebrospinal fluid (CSF) or blood samples holds great promises for cost-effective, widely accessible, easy-administrated noninvasive...
Rationale: As the transcriptional products of active enhancers, enhancer RNAs (eRNAs) are essential for initiation tumorigenesis. However, landscape and functional characteristics eRNAs in Chinese lung adenocarcinoma, clinical utility eRNA-based molecular subtypes remain largely unknown. Methods: A genome-wide profiling was performed 80 adenocarcinoma patients with RNA-seq data. Functional associated genes were identified between paired adjacent samples. Unsupervised clustering conducted...
The creatine transporter (CrT) maintains brain (Cr) levels, but the effects of its deficiency on energetics adaptation under stress remain unclear. There are also no effective treatments for CrT deficiency, second most common cause X-linked intellectual disabilities. Herein, we examined consequences in and stress-adaptation responses plus intranasal Cr supplementation. We found that CrT-deficient (CrT-/y) mice harbored dendritic spine synaptic dysgenesis. Nurtured newborn CrT-/y maintained...
Large language models (LLMs) have revolutionized Natural Language Processing (NLP) by minimizing the need for complex feature engineering. However, application of LLMs in specialized domains like biopharmaceuticals and chemistry remains largely unexplored. These fields are characterized intricate terminologies, knowledge, a high demand precision areas where general purpose often fall short. In this study, we introduce PharmGPT, suite multilingual with 13 billion 70 parameters, specifically...
To evaluate the prognostic value of left ventricular (LV) remodelling index (RI) in idiopathic dilated cardiomyopathy (DCM) patients.We prospectively enrolled 412 DCM patients and 130 age- sex-matched healthy volunteers who underwent cardiovascular magnetic resonance imaging between September 2013 March 2018. RI was defined as cubic root LV end-diastolic volume divided by mean wall thickness on basal short-axis slice. The primary endpoint included all-cause mortality heart transplantation....