A5019891864- Cancer, Hypoxia, and Metabolism
- Climate Change and Health Impacts
- Sphingolipid Metabolism and Signaling
- Peptidase Inhibition and Analysis
- Air Quality and Health Impacts
- Computational Drug Discovery Methods
- Metabolism, Diabetes, and Cancer
- Chemical Synthesis and Analysis
- Click Chemistry and Applications
- Cancer-related Molecular Pathways
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- ATP Synthase and ATPases Research
- Caveolin-1 and cellular processes
- Autophagy in Disease and Therapy
- Biochemical and Molecular Research
- Protein Kinase Regulation and GTPase Signaling
- RNA modifications and cancer
- Glycosylation and Glycoproteins Research
- SARS-CoV-2 and COVID-19 Research
- Receptor Mechanisms and Signaling
- Microtubule and mitosis dynamics
- Erythrocyte Function and Pathophysiology
- Amino Acid Enzymes and Metabolism
- Quinazolinone synthesis and applications
Fudan University
2016-2025
Quzhou University
2024-2025
Zhejiang Police College
2025
Tianjin Medical University General Hospital
2024
Tianjin Medical University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Cancer Institute (WIA)
2020-2023
Zhongshan Hospital
2020-2023
Soochow University
2022
First Affiliated Hospital of Soochow University
2022
Abstract A newly identified coronavirus, 2019-nCoV, has been posing significant threats to public health since December 2019. ACE2, the host cell receptor for severe acute respiratory syndrome coronavirus (SARS), recently demonstrated in mediating 2019-nCoV infection. Interestingly, besides system, substantial proportion of SARS and patients showed signs various degrees liver damage, mechanism implication which have not yet determined. Here, we performed an unbiased evaluation type specific...
<h2>Summary</h2><h3>Background</h3> The health impacts of climate warming are usually quantified based on daily average temperatures. However, extra risks might result from hot nights. We project the future mortality burden due to <h3>Methods</h3> selected night excess (HNE) represent intensity night-time heat, which was calculated as sum high temperature during time. collected historical data in 28 cities three east Asian countries, 1981 2010. associations between HNE and each city were...
Abstract The combination of immunotherapy and molecular targeted therapy exhibits promising therapeutic efficacy in hepatocellular carcinoma (HCC), but the underlying mechanism is still unclear. Here, phosphoglycerate mutase 1 (PGAM1) identified as a novel immunometabolic target by using bioinformatic algorithm based on multiple HCC datasets. PGAM1 highly expressed associated with poor prognosis response to immunotherapy. In vitro vivo experiments indicate that targeting inhibited cell...
We describe the rationale for and synthesis of a new class compounds utilizing modular approach that are designed to mimic ascorbic acid inhibit 2-oxoglutarate-dependent hydroxylases. Preliminary characterization one these indicates in vivo anticonvulsant activity (6 Hz mouse model) at nontoxic doses, inhibition hydroxylase FTO, expected increase cellular N6-methyladenosine. This compound is also able modulate various microRNA, an interesting result light recent view modulation microRNAs may...
Significance The day–night rhythm in living organisms controls many processes, which then oscillate a circadian manner. In addition, there are processes that appear continuous but the underlying mechanisms with distinct periods. For example, eukaryotic cells grow by extending their cell periphery pulses rather than extension. Here we investigate molecular basis for such oscillatory growth using unique tip system of filamentous fungi, where actin assembly, exocytosis, and rate were observed...
Abstract As the major component of cell membranes, phosphatidylcholine (PC) is synthesized de novo in Kennedy pathway and then undergoes extensive deacylation-reacylation remodeling via Lands’ cycle. The re-acylation catalyzed by lysophosphatidylcholine acyltransferase (LPCAT) among four LPCAT members human, LPCAT3 preferentially introduces polyunsaturated acyl onto sn-2 position lysophosphatidylcholine, thereby modulating membrane fluidity protein functions therein. Combining x-ray...
Abstract Floods have affected billions worldwide. Yet, the indirect health impacts of floods on vulnerable groups, particularly women in developing world, remain underexplored. Here, we evaluated risk pregnancy loss for exposed to floods. We analyzed 90,465 individual records from 33 countries, cross-referencing each with spatial-temporal flood databases. found that gestational exposure is associated increased an odds ratio 1.08 (95% confidence interval: 1.04 - 1.11). This pronounced outside...
Precise regulation of intracellular phosphate (Pi) is critical for cellular function, with xenotropic and polytropic retrovirus receptor 1 (XPR1) serving as the sole Pi exporter in humans. The mechanism efflux, activated by inositol pyrophosphates (PP-IPs), has remained unclear. This study presents cryo-electron microscopy structures XPR1 multiple conformations, revealing a transmembrane pathway export dual-binding activation pattern PP-IPs. A canonical binding site located at dimeric...
Multitarget drugs have been to be found effective in controlling complex diseases. However, how design multitarget presents a great challenge. We developed computer-assisted strategy screen for inhibitors using combination of molecular docking and common pharmacophore matching. This was successfully applied dual-target against both the human leukotriene A4 hydrolase (LTA4H-h) nonpancreatic secretory phospholipase A2 (hnps-PLA2). Three compounds screened from chemical database MDL Available...
A series of isatin derivatives were synthesized and tested against SARS CoV 3C-like protease. Substitutions at the N-1 C-5 positions examined to elucidate differences in substrate binding sites rhinovirus 3C protease Compound 5f shows significant inhibition with an IC50 0.37 μM. Further study showed that, unlike irreversible covalent human protease, compounds this are all noncovalent reversible inhibitors.