A5052071925- Lung Cancer Treatments and Mutations
- HER2/EGFR in Cancer Research
- Melanoma and MAPK Pathways
- Monoclonal and Polyclonal Antibodies Research
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Mycotoxins in Agriculture and Food
- Polyamine Metabolism and Applications
- Protein Degradation and Inhibitors
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Head and Neck Cancer Studies
- Cancer therapeutics and mechanisms
- Magnolia and Illicium research
- Carcinogens and Genotoxicity Assessment
- Occupational and environmental lung diseases
- PI3K/AKT/mTOR signaling in cancer
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Oxidative Organic Chemistry Reactions
- Cancer-related Molecular Pathways
- Phytochemical Studies and Bioactivities
- Cancer Immunotherapy and Biomarkers
- Cancer, Lipids, and Metabolism
- Advanced Biosensing Techniques and Applications
- Cell death mechanisms and regulation
The University of Texas Health Science Center at Tyler
2021-2024
Ningbo University
2024
The University of Texas at Tyler
2022
Emory University
2014-2021
Winship Cancer Institute
2014-2021
Huaiyin Institute of Technology
2020-2021
University of Georgia
2010-2018
Zero to Three
2015
Cancer Institute (WIA)
2014
Third People's Hospital of Hangzhou
2011
Abstract Purpose: The mechanisms accounting for anticancer activity of AZD9291 (osimertinib or TAGRISSO), an approved third-generation EGFR inhibitor, in EGFR-mutant non–small cell lung cancer (NSCLC) cells and particularly the subsequent development acquired resistance are unclear thus focus this study. Experimental Design: AZD9219-resistant lines were established by exposing sensitive to AZD9291. Protein alterations detected with Western blotting. Apoptosis was measured annexin V/flow...
Aflatoxin B1 (AFB1) is immunotoxic to animals and a suspected immunosuppressant in humans. In this study, we investigated the effects of AFB1 on splenic lymphocyte phenotypes inflammatory cytokine expression male F344 rats. Exposure [5-75 µg kg(-1) body weight (BW)] for 1 week showed dose-dependent decreases percentage CD8(+) T cells CD3(-) CD8a(+) NK cells. A general inhibition interleukin (IL)-4 interferon (IFN)-γ by CD4(+) cells, IL-4 IFN-γ tumor necrosis factor (TNF)-α natural killer...
Abstract Programmed death ligand-1 (PD-L1) is an immune checkpoint protein that has been linked with idiopathic pulmonary fibrosis (IPF) and fibroblast to myofibroblast transition (FMT). However, it remains largely unclear how PD-L1 mediates this process. We found significantly increased in the lungs of patients mice induced by bleomycin TGF-β. In primary human lung fibroblasts (HLFs), TGF-β expression dependent on both Smad3 p38 pathways. knockdown using siRNA attenuated TGF-β-induced...
Abstract Purpose: Our previous work suggested that HER3 inhibition sensitizes head and neck squamous cell carcinoma (HNSCC) to EGFR with cetuximab. This study aimed define the role of in cetuximab resistance antitumor mechanisms EGFR/HER3 dual targeting HNSCC. Experimental Design: We treated cetuximab-resistant HNSCC UMSCC1-C parental UMSCC1-P lines anti-EGFR antibody cetuximab, anti-HER3 MM-121, their combination. assessed activities HER2, HER3, downstream signaling pathways by Western...
The EGFR monoclonal antibody cetuximab is the only approved targeted agent for treating head and neck squamous cell carcinoma (HNSCC). Yet resistance to has hindered its activity in this disease. Intrinsic or compensatory HER3 signaling may contribute resistance. To investigate therapeutic benefit of combining MM-121/SAR256212, an anti-HER3 antibody, with HNSCC, we initially screened 12 HNSCC lines total phosphorylated levels four HER receptors. We also investigated combination MM-121...
Osimertinib (AZD9291), a third-generation, mutation-selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (EGFR-TKI), is an approved drug for patients who have non-small cell lung cancer (NSCLC) with activating EGFR mutations or those harboring resistant T790M mutation. Unfortunately, all eventually relapse and develop resistance to osimertinib. The current study addressed whether ERK inhibition exerts effects similar produced by MEK in overcoming acquired...
Background The major clinical obstacle that limits the long‐term benefits of treatment with osimertinib (AZD9291) in patients epidermal growth factor receptor‐mutant non–small cell lung cancer is development acquired resistance. Therefore, effective strategies can overcome resistance to are urgently needed. authors' current efforts this direction have identified LBH589 (panobinostat), a clinically used histone deacetylase inhibitor, as potential agent overcoming Methods Cell and apoptosis...
Background Osteoporosis is a degenerative bone disease predominantly in postmenopausal women. Green tea polyphenols (GTP) and Tai Chi (TC) have been shown to be beneficial on human health. This study examined the efficacy of GTP TC mitigation oxidative damage women with osteopenia. Methods A 6-month randomized placebo-controlled clinical trial was conducted 171 osteopenia, who were recruited from Lubbock County, Texas. These participants treated placebo, (500 mg daily), placebo + (60-minute...
BACKGROUND Although heregulin and human epidermal growth factor receptor 3 (HER3) are frequently expressed at high levels in patients with head neck cancer, their prognostic value remains unclear. The authors explored the significance of heregulin/HER3 expression oropharyngeal squamous cell carcinoma (OPSCC), taking into account other HER family members as well p16 status. METHODS Ninety‐six primary tumor specimens from OPSCC were retrospectively collected analyzed for messenger RNA (mRNA)...
The development of acquired resistance to osimertinib (Osim) (AZD9291 or TAGRISSOTM ), an FDA-approved third-generation epidermal growth factor receptor (EGFR) inhibitor for the treatment EGFR-mutant nonsmall cell lung cancer (NSCLC), limits long-term benefits patients. Thus, effective options are urgently needed. To this end, we explored whether honokiol (HNK), a natural product with potential antitumor activity, may be used overcome Osim resistance. combination HNK and synergistically...
Abstract Expression of programmed death-ligand 1 (PD-L1) on cancer cells is a critical mechanism contributing to immunosuppression and immune escape. PD-L1 expression may also affect therapeutic outcomes epidermal growth factor receptor (EGFR)-targeted therapy (e.g., with osimertinib/AZD9291) against EGFR-mutant non–small cell lung cancers (NSCLC) can even be altered during the treatment albeit largely undefined mechanisms. This study primarily focuses elucidating by which osimertinib...
BACKGROUND To understand the mechanism of frequent and early lymph node metastasis in high‐risk human papillomavirus (HPV)–associated oropharyngeal squamous cell carcinoma (OPSCC), this study investigated whether β‐catenin is regulated by HPV oncoprotein contributes to OPSCC metastasis. METHODS Expression levels p16, β‐catenin, epidermal growth factor receptor (EGFR) were examined samples (n = 208) immunohistochemistry. The expression subcellular localization EGFR activation also studied...
Autologous melanocytes can be expanded in vitro, allowing the treatment of large lesions vitiligo one session. Theoretically, this procedure could provide a higher donor/recipient size ratio (DR ratio) compared with that noncultured cell transplantation (with DR < 1 : 10). However, exact obtained from has not been reported.To study whether cultured pure at high is as efficient low ratio.One hundred and two patients were treated by divided into groups: group, including ≤ 10 (mean 8, 35 cases)...
In this study, male F344 rats were orally exposed to a single dose of aflatoxin B₁ (AFB₁) at 0, 50, 250, or 1,000 µg/kg body weight (BW) repeated 5, 10, 25, 75 BW for up 5 weeks. Biochemical and histological changes assessed together with the formation AFB1-lysine adduct (AFB-Lys) liver foci positive placental form glutathione S transferase (GST-P⁺). single-dose protocol, serum aspartate transaminase (AST), alanine (ALT), alkaline phosphatase (ALP) showed dose-related elevation, maximal...
Aflatoxins (AF) are a group of mycotoxins. AF exposure causes acute and chronic adverse health effects such as aflatoxicosis hepatocellular carcinoma in human populations, especially the developing world. In this study, was evaluated using archived serum samples from immunodeficiency virus (HIV)-seronegative participants two cohort studies south-western Uganda. AFB1–lysine (AFB-Lys) adduct levels were determined via HPLC fluorescence total 713 General Population Cohort (GPC), covering eight...