A5111736245- Mycotoxins in Agriculture and Food
- Ginkgo biloba and Cashew Applications
- Hepatitis B Virus Studies
- Carcinogens and Genotoxicity Assessment
- Cancer, Lipids, and Metabolism
- Cancer-related Molecular Pathways
- Liver Disease Diagnosis and Treatment
- Cancer Research and Treatments
- Glutathione Transferases and Polymorphisms
- Cancer, Hypoxia, and Metabolism
- Folate and B Vitamins Research
- Hepatitis C virus research
- Lung Cancer Treatments and Mutations
- HER2/EGFR in Cancer Research
- Redox biology and oxidative stress
- Caveolin-1 and cellular processes
- Neurological Disease Mechanisms and Treatments
- Cancer-related molecular mechanisms research
- Viral Infections and Vectors
- RNA modifications and cancer
- Traditional Chinese Medicine Studies
- Cancer Cells and Metastasis
- Advanced Surface Polishing Techniques
- Tea Polyphenols and Effects
- Glycosylation and Glycoproteins Research
Shenzhen University
2024
Xiamen University
2011-2022
University of Georgia
2013-2018
Nanchang Hangkong University
2016
Guangxi Medical University
1999-2015
Tumor Hospital of Guangxi Medical University
2008-2015
First Affiliated Hospital of GuangXi Medical University
2011-2013
Cancer Institute (WIA)
2007-2008
Texas Tech University
2007
Temple University
1997-1998
Abstract Fumonisin B1 (FB1) is reportedly the causative agent of several animal mycotoxicoses and has etiologically been linked to human oesophageal liver cancer in certain areas South Africa China. To study a possible relationship between exposure FB1 risk, current status contamination food samples Huaian Fusui, where incidences are amongst highest China, was investigated. A total 259 corn were collected from individual households five villages different townships during December 2001 2002,...
Abstract Aflatoxins and fumonisins are ubiquitous foodborne toxicants the co-occurrence of these mycotoxins in human foods represents a significant public health concern, which has been strongly associated with aflatoxicosis, neural tube defects, as well many types primary cancers. In this study co-contamination aflatoxin B1 (AFB1) fumonisin (FB1) food dietary exposure was investigated residents three different areas China. A total 209 samples were measured for AFB1 FB1. The median levels...
Aflatoxin B1 (AFB1) is immunotoxic to animals and a suspected immunosuppressant in humans. In this study, we investigated the effects of AFB1 on splenic lymphocyte phenotypes inflammatory cytokine expression male F344 rats. Exposure [5-75 µg kg(-1) body weight (BW)] for 1 week showed dose-dependent decreases percentage CD8(+) T cells CD3(-) CD8a(+) NK cells. A general inhibition interleukin (IL)-4 interferon (IFN)-γ by CD4(+) cells, IL-4 IFN-γ tumor necrosis factor (TNF)-α natural killer...
Levels of serum and urinary sphinganine (Sa) sphingosine (So), the Sa/So ratio, urinary-free fumonisin B(1) (FB(1)) were determined in a cross-sectional study consisting 43 adults Huaian 34 Fusui, China. Home-produced corn had 100% contamination with FB(1). There 93.0% (40/43) subjects 52.9% (18/34) Fusui daily FB(1) intakes greater than 2 microg kg(-1) body weight, which showed significant difference (p < 0.01). ratio not correlated levels dietary exposure. The median level (0.41, range =...
Hepatitis B virus (HBV) infection has been believed as a major cause of hepatocellular carcinoma (HCC) for long time, however, the evidences which are mostly from clinical and epidemiological investigations while there is no evidence animal experiments. Tree shrew (Tupaia) small closely related to primates evolutionarily, with about 8 years lifespan. Our previous study proved that tree shrews can be chronically HBV-infected after being inoculated neonatally HBV. The present reports further...
In this study, male F344 rats were orally exposed to a single dose of aflatoxin B₁ (AFB₁) at 0, 50, 250, or 1,000 µg/kg body weight (BW) repeated 5, 10, 25, 75 BW for up 5 weeks. Biochemical and histological changes assessed together with the formation AFB1-lysine adduct (AFB-Lys) liver foci positive placental form glutathione S transferase (GST-P⁺). single-dose protocol, serum aspartate transaminase (AST), alanine (ALT), alkaline phosphatase (ALP) showed dose-related elevation, maximal...
An animal model for HBV that more closely approximates the disease in humans is needed. The tree shrew (Tupaia belangeri) related to primates and susceptible HBV. We previously established neonatal shrews can be persistently infected with vivo, here present a six year follow-up histopathological study of these animals.Group A consists persistent infection, group B three suspected while C four free infection. Serum liver tissues samples were collected periodically from all animals. antigen...
The physicochemical principle of photocorrosion and photoetching is the internal photoelectric effect semiconductors. However, kinetic investigation interfacial charge transfer induced by this phenomenon has been seldom reported due to its microdomain bipolarity. GaAs a direct band gap semiconductor with high saturated electron velocity mobility. Once photogenerated electrons on n-type surface are removed Fe3+ in solution, it will dissolve residual positive holes; i.e., process occur. By...
Abstract Background Hepatitis B virus (HBV) infection continues to be an escalating global health problem. Feasible and effective animal models for HBV are the prerequisite developing novel therapies this disease. The tree shrew ( Tupaia ) is a small species evolutionary closely related humans, thus permissive certain human viral pathogens. Whether shrews could chronically infected with in vivo has been controversial decades. Most published research reported on adult shrews, only numbers of...
In order to explore the proteins responsible for hepatocellular carcinoma (HCC), aflatoxin B(1)-induced hepatocarcinogenesis in tree shrew (Tupaia belangeri chinensis) was analyzed with 2-DE and MS. By comparing HCC samples their own precancerous biopsies HCC-surrounding tissues, a group of candidate that differentially expressed were obtained. Peroxiredoxin (Prx) II, one candidates distinct alteration, further investigated validated. Western blot RT-PCR assays confirmed overexpression Prx...
Abstract Green tea polyphenols (GTP) are highly effective in inhibiting a variety of tumorigenic effects induced by carcinogens. In this study we assessed GTP mitigation on biomarkers fumonisin B 1 (FB ), class 2B carcinogen, blood and urine samples collected from an intervention trial. A total 124 exposed people were recruited randomly assigned to low-dose (GTP 500 mg, n = 42), high-dose 1,000 41) or placebo (n for 3 months. After one-month intervention, urinary FB was significantly...
Aim: To explore gene expression profiles during hepatocarcinogenesis of the tree shrew, and to find genes responsible for human hepatocellular carcinoma (HCC). Methods: Tree shrews were used as an animal model HCC induction employing aflatoxin B 1 (AFB ) alone or AFB plus hepatitis virus (HBV) etiological factors. Gene from tissues HCC, HCC‐surrounding liver (para‐HCC) corresponding biopsies taken same animals before had developed (pre‐HCC) analyzed by cDNA microarray assay identify...
In this paper, we present an electrochemically driven large amplitude pH alteration method based on a serial electrolytic cell involving hydrogen permeable bifacial working electrode such as Pd thin foil. The allows solution to be changed periodically up ±4~5 units without additional of concentration and/or composition the system. Application acid-base cyclic denaturation and renaturation 290 bp DNA fragments is successfully demonstrated with in situ real-time UV spectroscopic...
Background: Hepatocellular carcinoma (HCC) is one of the most common and aggressive cancers worldwide, pathogenesis very complicated at present. There rare effective therapeutic measure, novel strategies are urgently required to improve clinical outcome. Ginkgo biloba extract (EGb) reported be with an anti-cancer activity. Objectives: This study was performed explore effect EGb on expressions cyclooxygenase-2 (Cox-2) glutathione S-transferase Pi (GST-Pi) in HCC risk. Methods: 120 Wistar rats...