A5100766892- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease and Transplantation
- Cancer, Lipids, and Metabolism
- Inflammatory Biomarkers in Disease Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- Pancreatic and Hepatic Oncology Research
- Alcohol Consumption and Health Effects
- Cancer-related Molecular Pathways
- Nutrition and Health in Aging
- RNA modifications and cancer
- Cancer Research and Treatments
- Ferroptosis and cancer prognosis
- Viral-associated cancers and disorders
- Molecular Biology Techniques and Applications
- Occupational and environmental lung diseases
- Lung Cancer Treatments and Mutations
- Nitrogen and Sulfur Effects on Brassica
- Polyomavirus and related diseases
- Gut microbiota and health
- Glutathione Transferases and Polymorphisms
- Cytokine Signaling Pathways and Interactions
Guangxi Medical University
2005-2024
Ministry of Education of the People's Republic of China
2022
Tumor Hospital of Guangxi Medical University
2011-2020
First Affiliated Hospital of GuangXi Medical University
2005-2020
Guangxi Science and Technology Department
2019
GTx (United States)
2019
China Agricultural University
2017
Huashan Hospital
2016
Fudan University
2016
Abstract Background & Aims p53 is one of the most frequently mutated human tumour suppressor genes. Chronic infection with hepatitis B virus ( HBV ) and exposure to aflatoxin B1 AFB 1) induces mutations in hepatocellular carcinoma HCC tissue. The aims present study are investigate mutation spectrum ‐ 1‐related hepatocarcinogenesis patients Guangxi, China. Methods Tumour adjacent liver tissue were collected from 397 who subdivided into (+)/ 1(+), 1(−), (−)/ 1(+) 1(−) four groups. All 11...
Background: Systemic inflammatory response is a hallmark of cancer and plays significant role in the development progression various malignant tumors. This research aimed to estimate prognostic function C-reactive protein-albumin ratio (CAR) patients undergoing hepatectomy for hepatocellular carcinoma (HCC) compare it with other inflammation-based scores, including neutrophil-lymphocyte ratio, platelet-lymphocyte monocyte-lymphocyte systemic immune inflammation index, Glasgow score, modified...
Misregulation of the p53-mdm2 loop function is a major mechanism to promote hepatocellular carcinoma (HCC). RBM38, member RNA recognition motif (RRM) family binding proteins (RBPs), plays fundamental role in posttranscriptional control gene expression and regulatory functions human tumors. A novel RBM38-p53-mdm2 autoregulatory feedback has been demonstrated. However, its mechanistic HCC remains unclear.In present study, we investigated molecular misregulation by RBM38 HCC. First correlation...
This study aimed to investigate the efficacy of preoperative aspartate aminotransferase-to-platelet-ratio index (APRI) score predict risk posthepatectomy liver failure (PHLF) in patients with hepatocellular carcinoma (HCC) after resection, and compare discriminatory performance APRI Child-Pugh score, model for end-stage disease (MELD) albumin-bilirubin (ALBI) score.A total 1,044 consecutive HCC who underwent resection were enrolled studied. Univariate multivariate analyses performed factors...
Background & Aims Official guidelines do not recommend hepatic resection (HR) for patients with hepatocellular carcinoma (HCC) and portal hypertension (PHT). This study aims to investigate the safety efficacy of HR HCC PHT. Methods Mortality survival after were analyzed retrospectively in a consecutive sample 1738 PHT (n = 386) or without it 1352). To assess robustness findings, we repeated analysis using propensity score-matched analysis. We also comprehensively searched PubMed database...
To investigate whether an elevated preoperative neutrophil-to-lymphocyte ratio (NLR) can predict poor survival in patients with hepatocellular carcinoma (HCC).We retrospectively reviewed 526 HCC who underwent surgery between 2004 and 2011.Preoperative NLR ≥ 2.81 was independent predictor of disease-free (DFS, P < 0.001) overall (OS, = 0.044). Compared showed a postoperative increase, decrease had worse 0.001; OS, 0.001). Among 2.81, significantly higher among those showing than increase When...
Both hepatitis B virus (HBV) and aflatoxin B1 (AFB1) exposure can cause liver damage as well increase the probability of hepatocellular carcinoma (HCC). To investigate underlying genetic changes that may influence development HCC associated with HBV infection AFB1 exposure, patients were subdivided into 4 groups depending upon status: (HBV(+)/AFB1(+), HBV(+)/AFB1(-), HBV(-)/AFB1(+), HBV(-)/AFB1(-)). Genetic abnormalities protein expression profiles analyzed by array-based comparative genomic...
Post-hepatectomy liver failure (PHLF) is a severe complication in hepatocellular carcinoma (HCC) patients who have undergone hepatectomy. This research aimed to investigate the combination of albumin-bilirubin (ALBI) score and aspartate aminotransferase-platelet ratio index (APRI) as novel approach predicting PHLF risk hepatitis B virus (HBV)-related HCC patients.HBV-related underwent hepatectomy from January 2006 October 2013 were enrolled this study. A model was constructed using ALBI APRI...
Background/Aims: Hepatocellular carcinoma (HCC) is a common malignant tumor with high rate of recurrence. Immunohistochemical analysis the marker proliferation Ki-67 (MKI67) used to assess activity HCC The regulation MKI67 expression remains unclear in This study aims explore association between and gene variants. Methods: A total 195 hepatitis B virus (HBV)-related patients were genotyped using Illumina HumanExome BeadChip-12-1_A (242,901 markers). An independent cohort (97 subjects)...
Background Whether obesity affects surgical outcomes in patients with hepatocellular carcinoma (HCC) is controversial. Here we retrospectively evaluated the impact of on HCC after curative hepatectomy. Methods Patients Child-Pugh A liver function who underwent hepatectomy between 2006 and 2010 were categorized as obese (BMI ≥25 kg/m2, n = 68) non-obese (<25 242). To reduce interference from baseline differences two groups, propensity score-matched analysis was performed ratio 1:2 using a...
Purpose To investigate pre‐ and post‐operative levels of HBsAg influence prognosis patients with hepatitis B virus (HBV)‐related hepatocellular carcinoma (HCC) after curative resection. Methods Medical records were retrospectively analyzed for 881 HBV‐related HCC treated by Patients classified as having high or low serum (≥200 <200 ng/mL) post‐operatively. Results OS RFS better pre‐operative than those levels. Similarly, was among RFS, in contrast, similar between these two groups. After...
Background: Exposure to dietary aflatoxin B1 (AFB1) induces DNA damage and mutation in the TP53 gene at codon 249, known as R249S mutation, is a major risk factor for hepatocellular carcinoma (HCC). AFB1 hepatitis B virus (HBV) together exert synergistic effects that promote carcinogenesis HCC. Methods: A genome-wide association study (GWAS) of whole genome exons was conducted using 485 HCC patients with chronic HBV infection. This followed by an independent replication 270...
Abstract Background To develop a nomogram for predicting the International Study Group of Liver Surgery (ISGLS) grade B/C posthepatectomy liver failure (PHLF) in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) patients. Methods Patients initially treated with hepatectomy were included. Univariate regression analysis and stochastic forest algorithm applied to extract core indicators reduce redundancy bias. The was then constructed by using multivariate logistic regression,...
Abstract Background The accurate prediction of post-hepatectomy early recurrence (PHER) hepatocellular carcinoma (HCC) is vital in determining postoperative adjuvant treatment and monitoring. This study aimed to develop validate an artificial neural network (ANN) model predict PHER HCC patients without macroscopic vascular invasion. Methods Nine hundred three who underwent curative liver resection for participated this study. They were randomly divided into derivation ( n = 679) validation...
// Wen-Feng Gong 1, 2, * , Jian-Hong Zhong Shi-Dong Lu 2 Xiao-Bo Wang Qiu-Ming Zhang 3 Liang Ma Zhi-Ming Bang-De Xiang Le-Qun Li 1 Hepatobiliary Surgery Department, Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China Liver Cancer Diagnosis and Treatment Engineering Technology Research Center, General Medicine The First People Qinzhou, 535000, These authors contributed equally to this work as co-first Correspondence to: Li, email: xitongpingjia@163.com Xiang,...
// Xiwen Liao 1, * , Chuangye Han Wei Qin Xiaoguang Liu 2 Long Yu 3 Guangzhi Zhu 1 Tingdong Sicong Lu Hao Su Zhen Zhiwei Chen Chengkun Yang Ketuan Huang Zhengtao Liang Jianlu 4 Jiahong Dong 5 Lequn Li 6 Xue 7 Xinping Ye Kaiyin Xiao Minhao Peng Tao Department of Hepatobiliary Surgery, The First Affiliated Hospital Guangxi Medical University, Nanning, 530021, Province, China Guangdong Zhanjiang, 524001, and Pancreatic Zhengzhou Zhengzhou, 450000, Henan Third 530031, Hepato-Biliary-Pancreatic...