A5101872132- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Folate and B Vitamins Research
- Hepatitis B Virus Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Alzheimer's disease research and treatments
- Hepatitis C virus research
- Gallbladder and Bile Duct Disorders
- Lipid metabolism and disorders
- Alcohol Consumption and Health Effects
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- Molecular Biology Techniques and Applications
- Renal Transplantation Outcomes and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gout, Hyperuricemia, Uric Acid
- Parkinson's Disease Mechanisms and Treatments
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Kruppel-like factors research
- Genetic Associations and Epidemiology
- Metabolism, Diabetes, and Cancer
- Adrenal and Paraganglionic Tumors
Shanghai Institute of Organic Chemistry
2021-2025
Chinese Academy of Sciences
2021-2025
University of Chinese Academy of Sciences
2021-2025
Hangzhou Red Cross Hospital
2022-2024
Zhejiang Shuren University
2022-2024
First Affiliated Hospital Zhejiang University
2017-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
Zhejiang University
2015-2023
Blood Center of Zhejiang Province
2015-2023
First Affiliated Hospital of GuangXi Medical University
2014-2018
Significance Amyloid deposition of α-syn is a hallmark PD. Heterozygous point mutations are associated with the early-onset and rapid progression fPD. In this study, we found fibril strain formed by familial mutant hE46K induced motor deficit enhanced aggregation in vivo. More importantly, showed through cryogenic electron microscopy vivo studies E46K can template wild-type monomer to form amyloid fibrils, which inherit both structure propagation potency template. Our work reveals structural...
Previous studies revealed the potential significance of circulating adiponectin levels with respect to diagnosis and prediction metabolic syndrome, but uncertainty has been noted across different cohorts. Systematic evaluation was performed for diagnostic accuracy predictivity variation syndrome in enrolled including 1,248 6,020 subjects, respectively. Adiponectin can identify moderate (area under curve = 0.81, 95% CI: 0.77-0.84). Heterogeneity analysis that an increasing index insulin...
In vitro assembly of amyloid fibrils that recapitulate those in human brains is very useful for fundamental and applied research on the formation, pathology, clinical detection. Recent success Tau enables recapitulation paired helical filament (PHF) extracted from patients with Alzheimer's disease (AD). However, following protocol, we observed constructs including 297-391 a mixture 266-391 (3R)/297-391, which are expected to predominantly form PHF-like fibrils, highly heterogeneous instead....
α-synuclein (α-Syn) is a presynaptic protein that involved in Parkinson’s and other neurodegenerative diseases binds to negatively charged phospholipids. Previously, we reported α-Syn clusters synthetic proteoliposomes mimic synaptic vesicles. This vesicle-clustering activity depends on specific interaction of with anionic Here, report surprisingly also interacts the neutral phospholipid lysophosphatidylcholine (lysoPC). Even absence lipids, lysoPC facilitates α-Syn-induced vesicle...
Abstract Hepatocellular carcinoma ( HCC ) is one of the most prevalent malignancies and a major cause cancer involved death worldwide. Prognosis remains poor because high recurrence rates lack effective relapse prevention strategies. Notch pathway plays an important role in tumor progression metastasis, it associated with prognosis cancer. A total 465 hepatitis B virus HBV )‐related patients who underwent surgery were enrolled. Single nucleotide polymorphisms SNP receptors genotyped using...
Background: Exposure to dietary aflatoxin B1 (AFB1) induces DNA damage and mutation in the TP53 gene at codon 249, known as R249S mutation, is a major risk factor for hepatocellular carcinoma (HCC). AFB1 hepatitis B virus (HBV) together exert synergistic effects that promote carcinogenesis HCC. Methods: A genome-wide association study (GWAS) of whole genome exons was conducted using 485 HCC patients with chronic HBV infection. This followed by an independent replication 270...
Liver transplantation (LT) is one of the most effective surgical treatment for patients with end-stage liver disease. Steatosis a contributor inferior graft quality. But its impact and safety on was less assessed in Chinese patients.Graft steatosis related information involved recipients, donors procedures were retrospectively collected from 239 patients.Donor macrosteatosis (MaS) caused about 2.14 2.80 folds increment patient mortality. Dose-response analysis revealed prominent risk grafts...
Background: Low-grade glioma (LGG) is considered a fatal disease for young adults, with overall survival widely ranging from 1 to 15 years depending on histopathologic and molecular subtypes. As novel type of programmed cell death, ferroptosis was reported be involved in tumorigenesis development, which has been intensively studied recent years. Methods: For the discovery cohort, data The Cancer Genome Atlas (TCGA) Genotype-Tissue Expression (GTEx) were used identify differentially expressed...
Although recent studies have reported the regulation of immune response in hepatocellular carcinoma (HCC) through DNA methylation, comprehensive impact methylation modifications on tumor microenvironment characteristics and immunotherapy efficacy has not been fully elucidated.
// Xiwen Liao 1, * , Chuangye Han Wei Qin Xiaoguang Liu 2 Long Yu 3 Guangzhi Zhu 1 Tingdong Sicong Lu Hao Su Zhen Zhiwei Chen Chengkun Yang Ketuan Huang Zhengtao Liang Jianlu 4 Jiahong Dong 5 Lequn Li 6 Xue 7 Xinping Ye Kaiyin Xiao Minhao Peng Tao Department of Hepatobiliary Surgery, The First Affiliated Hospital Guangxi Medical University, Nanning, 530021, Province, China Guangdong Zhanjiang, 524001, and Pancreatic Zhengzhou Zhengzhou, 450000, Henan Third 530031, Hepato-Biliary-Pancreatic...
Novel immunotherapy is one of the options for advanced biliary tract cancer (BTC) patients who are traditionally intolerant to chemotherapy. However, clinical evidence single with pembrolizumab or nivolumab limited. The present study assessed safety and efficiency anti-PD-1 antibody, camrelizumab, as monotherapy in unresectable recurrent BTC.A retrospective evaluation was conducted among 4 BTC, including 2 intrahepatic cholangiocellular carcinoma (ICC), extrahepatic bile duct cancer,...
Background: Our previous study revealled amplified hazardous effects of macrosteatosis (MaS) on graft failure (GF) in recipients with severe liver damage short post-operative days, vague mechanism inside. Aim: We aimed to uncover the molecular donor MaS GF, and construct predictive model monitor post-transplant prognosis based "omics" perspective. Methods: Ultra-performance liquid chromatography coupled mass spectrometry metabolomic analysis was performed allograft tissues from 82 patients...
NM23 expression is closely associated with hepatocellular carcinoma (HCC) recurrence, but the hereditary factors influencing levels are unknown. Using public database, diagnostic value of in HCC was investigated. A total 424 hepatitis B virus- (HBV-) related patients were enrolled to perform a genome–wide association study for identifying candidate variants level. Additionally, logistic regression model, haplotypes, and survival analysis performed subsequent analysis. We identified high that...