A5100749878- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Renal Transplantation Outcomes and Treatments
- Liver Disease Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Acute Kidney Injury Research
- Renal and related cancers
- Epigenetics and DNA Methylation
- Chronic Kidney Disease and Diabetes
- Cancer-related Molecular Pathways
- Clinical Nutrition and Gastroenterology
- Renal Diseases and Glomerulopathies
- Urinary Bladder and Prostate Research
- Transplantation: Methods and Outcomes
- Hepatitis B Virus Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Cellular transport and secretion
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Tracheal and airway disorders
- Protein Degradation and Inhibitors
- Prostate Cancer Diagnosis and Treatment
- Vasculitis and related conditions
- Neonatal Respiratory Health Research
- Head and Neck Anomalies
- Metabolism and Genetic Disorders
Second Xiangya Hospital of Central South University
2022-2025
Central South University
2022-2025
Nanjing University of Chinese Medicine
2024
Columbia University
2009-2024
Zhejiang University
2004-2023
First Affiliated Hospital Zhejiang University
2016-2023
Shanghai University
2023
West China Hospital of Sichuan University
2019-2021
Weatherford College
2021
Sichuan University
2019-2021
Although bladder cancer represents a serious health problem worldwide, relevant mouse models for investigating disease progression or therapeutic targets have been lacking. We show that combined deletion of p53 and Pten in epithelium leads to invasive novel model. Inactivation PTEN promotes tumorigenesis human cells is correlated with poor survival tumors. Furthermore, the synergistic effects are mediated by deregulation mammalian target rapamycin (mTOR) signaling, consistent ability block...
α–Intercalated cells (A-ICs) within the collecting duct of kidney are critical for acid-base homeostasis. Here, we have shown that A-ICs also serve as both sentinels and effectors in defense against urinary infections. In a murine tract infection model, bound uropathogenic E. coli responded by acidifying urine secreting bacteriostatic protein lipocalin 2 (LCN2; known NGAL). A-IC–dependent LCN2 secretion required TLR4, mice expressing an LPS-insensitive form TLR4 expressed reduced levels...
Two metrics, a rise in serum creatinine concentration and decrease urine output, are considered tantamount to the injury of kidney tubule epithelial cells thereof (AKI). Yet neither criterion emphasizes etiology or pathogenetic heterogeneity acute decreases excretory function. In fact, whether decreased function due contraction extracellular fluid volume (vAKI) intrinsic (iAKI) actually share pathogenesis should be aggregated same diagnostic group remains an open question. To examine this...
Hepatocellular carcinoma (HCC) is the main cause of cancer-related deaths in adult men under age 60 years China.[1] Liver transplantation (LT) generally recognized as one most effective therapeutic approaches for end-stage liver diseases. LT guidelines HCC were firstly launched 2014 and updated 2018. Recently, further updates are required to adapt new situation China continue advancing recommendations. (Full version Supplementary file, https://links.lww.com/CM9/B362). The classification...
Holliday junction recognition protein (HJURP) has been implicated in many cancers including hepatocellular carcinoma (HCC). However, the underlying mechanism by which HJURP promotes HCC cell proliferation remains unclear.RT-qPCR and immunohistochemistry were used to detect expression adjacent tumor tissues lines. The localization of p21 determined immunofluorescence western blot. Co-immunoprecipitation blot validate stability signaling pathways affected HJURP. effects on assessed both vivo...
Abstract Background and Aim: Intestinal microflora play a crucial role in some severe liver diseases. The purpose of this study was to evaluate the effects Lactobacillus strain Bifidobacterium on ischemia‐reperfusion (I/R) injury. Methods: Rats were divided into six groups. Each group received either Catenulatum ZYB0401; Fermentum ZYL0401; mixture these two bacterial strains; gentamicin; or saline by daily gavage for 7 days. On sixth day, all rats, except those control group, subjected 20...
// Yujie Zhang 1, 2, 3 , Jun Du Jianchao Zheng Jiaojing Liu 2 Rui Xu 4 Tian Shen Yichao Zhu Chang Hong Wang Zhihong 5 Fanqing Meng 6 Yan 7 Yongchang Chen 8 Yong 9 Luo Gu 1 Cancer Center, Nanjing Medical University, Nanjing, Jiangsu 210029, China Department of Biochemistry and Molecular Biology, Physiology, Biotechnology, Pathophysiology, the First Affiliated Hospital Drum Tower University School, 210008, Second 210011, School Science Laboratory Medicine, Zhenjiang, 212013, Correspondence to:...
Alveolar epithelial type 2 (AT2) cells harbor the facultative progenitor capacity in lung alveolus to drive regeneration after injury. Using single-cell transcriptomics, software-guided segmentation of tissue damage, and vivo mouse lineage tracing, we identified grainyhead transcription factor cellular promoter 2-like 1 (Tfcp2l1) as a regulator this regenerative process. Tfcp2l1 loss adult AT2 inhibits self-renewal enhances AT2-AT1 differentiation during regeneration. Conversely, blunts...
We have identified and cloned the cDNA for a 912-aa protein, rab11BP, that interacts with GTP-containing active form of rab11, GTP-binding protein plays critical role in receptor recycling. Although rab11BP is primarily cytosolic, significant fraction colocalizes rab11 endosomal membranes both sorting recycling subcompartments. In vitro binding to native requires partial denaturation latter expose an internal site located between residues 334 504 apparently masked by C-terminal portion which...
To investigated the link between distribution of abdominal fat and concentration serum uric acid (SUA) in individuals recently diagnosed with type 2 diabetes.Studied 364 had been diabetes within one month, evaluated factors such as abdomen, indicators related to glucose lipid metabolism. The participants' SUA concentrations were divided into a normal control group (CG) hyperuricemia (HG).The HG elevated subcutaneous area (SFA), visceral content (VFA), body mass index (BMI), fasting blood...
To determine whether adult kidney papillary label-retaining cells (pLRCs) are specialized precursors, we analyzed their transcription profile. Among genes overexpressed in pLRCs, selected candidate to perform qPCR and immunodetection of encoded proteins. We found that Zfyve27, which encodes protrudin, identified a subpopulation pLRCs. With Zfyve27-CreERT2 transgenic reporter mice generated bitransgenic animals performed cell-lineage analysis. Post tamoxifen, marked preferentially located the...
Abstract To compare the performance of eight score systems (MELD, uMELD, MELD-Na. iMELD, UKELD, MELD-AS, CTP, and mCTP) in predicting post-transplant mortality, we analyzed data 6,014 adult cirrhotic patients who underwent liver transplantation between January 2003 December 2010 from China Liver Transplant Registry database. In hepatitis B virus (HBV) group, MELD, uMELD MELD-AS showed good predictive accuracies at 3-month mortality after transplantation; by comparison with other five models,...
Using a cytosol and nucleotide dependent assay that we previously developed, have investigated the requirement for coat proteins in vitro production of trans-Golgi network (TGN)-derived vesicles from Madin-Darby canine kidney (MDCK) cell Golgi fraction contains 35 S-labeled, terminally glycosylated, envelope glycoprotein vesicular stomatitis virus (VSV-G) accumulated TGN. We found TGN-derived vesicles, like those involved intra-Golgi transport retrograde to endoplasmic reticulum, contain...
Community-acquired pneumonia (CAP) is a major concern in hospitals and the bacterial community of which has not been systemically discussed yet. Sputum from patients acute stages kind accessible sample reflecting its features. In our study, we analyzed 45 sputum samples with CAP. Eighteen healthy people were chosen as controls. Pyrosequencing 16s rDNA V3 hypervariable regions all bacteria contained was used culture-independent method to disclose constitution. Also, published data for...