A5103283844- Cancer Genomics and Diagnostics
- Wnt/β-catenin signaling in development and cancer
- Glycosylation and Glycoproteins Research
- Optical Wireless Communication Technologies
- Lung Cancer Treatments and Mutations
- Hepatitis B Virus Studies
- Aldose Reductase and Taurine
- Advanced Wireless Communication Technologies
- Cancer Research and Treatments
- Cellular transport and secretion
- Fibroblast Growth Factor Research
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Histone Deacetylase Inhibitors Research
- Protein Degradation and Inhibitors
- IoT Networks and Protocols
- Ubiquitin and proteasome pathways
- Diabetes Management and Education
- Fetal and Pediatric Neurological Disorders
- Endoplasmic Reticulum Stress and Disease
- Metallic Glasses and Amorphous Alloys
- Industrial Vision Systems and Defect Detection
- Image and Object Detection Techniques
- Cell death mechanisms and regulation
Wenzhou Medical University
2024-2025
Dongguan University of Technology
2024
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2024
Huizhou University
2023-2024
BGI Group (China)
2019-2023
Air Force Medical University
2023
BGI Genomics
2019-2022
University of Chinese Academy of Sciences
2019-2022
Nanjing Medical University
2013-2019
Central South University
2008-2009
CD24, a mucin-like membrane glycoprotein, plays critical role in carcinogenesis, but its human gastric cancer and the underlying mechanism remains undefined. The contents of CD24 epidermal growth factor receptor (EGFR) cells (SGC-7901 BGC-823) non-malignant epithelial (GES-1) were evaluated by Western blotting assay. Cellular EGFR staining was examined immunofluorescence Cell migration rate measured wound healing effects depletion/overexperssion on expression activation EGF/EGFR singaling...
// Yujie Zhang 1, 2, 3 , Jun Du Jianchao Zheng Jiaojing Liu 2 Rui Xu 4 Tian Shen Yichao Zhu Chang Hong Wang Zhihong 5 Fanqing Meng 6 Yan 7 Yongchang Chen 8 Yong 9 Luo Gu 1 Cancer Center, Nanjing Medical University, Nanjing, Jiangsu 210029, China Department of Biochemistry and Molecular Biology, Physiology, Biotechnology, Pathophysiology, the First Affiliated Hospital Drum Tower University School, 210008, Second 210011, School Science Laboratory Medicine, Zhenjiang, 212013, Correspondence to:...
Background: Diabetes apps have the potential to improve self-management among people with type 2 diabetes mellitus (T2DM) and thereby prevent complications. However, premature disengagement of hinders this potential. Objective: This study aimed identify facilitators barriers continued use T2DM patients formulate recommendations enhance patients’ adherence apps. Design: Qualitative that followed Consolidated Criteria for Reporting. Research (COREQ) guidelines. Methods: Semi-structured...
Survivin is overexpressed in cancer cells and plays a crucial role apoptosis evasion. YM155, small-molecule inhibitor of survivin, could enhance the cytotoxicity various DNA-damaging agents. Here, we evaluated radiosensitizaion potential YM155 human esophageal squamous cell carcinoma (ESCC).Cell viability was determined by CCK8 assay. The radiosensitization effect clonogenic survival progression tumor xenograft. Cell cycle flow cytometric analysis. Radiation-induced DNA double strand break...
Melatonin, a naturally-occurring hormone, possesses antioxidant properties and ameliorates vascular endothelial dysfunction. In this study, we evaluate the impact of melatonin on migratory capability human umbilical vein cells (HUVECs) to hypoxia further investigate whether ERK/Rac1 signaling is involved in process. Here, found that inhibited hypoxia-stimulated hypoxia-inducible factor-1α (HIF-1α) expression cell migration dose-dependent manner. Mechanistically, Rac1 activation suppressed...
Abstract Background Recently, increasing innovations improved the accuracy of next generation sequencing (NGS) data. However, validation all NGS variants increased cost and turn‐around time clinical diagnosis, therefore limited further development applications. We aimed to comprehensively assess necessity validating variants. Methods Validation data 7,601 involving 1,045 genes were collected from 5,190 samples sequenced by one five targeted capture panels two chemistries, respectively. These...
Curcumin, an extensively utilized natural pigment in the food industry, has attracted considerable attention due to its potential therapeutic effects, such as anti-tumorigenic and anti-inflammatory activities. The enzyme 17β-Hydroxysteroid dehydrogenase 1 (17β-HSD1) holds a crucial position oestradiol production exhibits significant involvement oestrogen-responsive breast cancers endometriosis. This study investigated inhibitory effects of curcuminoids, metabolites, analogues on 17β-HSD1,...
E-cadherin internalization facilitates dissolution of adherens junctions and promotes tumor cell epithelial-mesenchymal transition (EMT) migration. Our previous results have shown that Arf6 exerts pro-migratory action in breast cancer cells after EGF stimulation. Despite the fact signaling stimulates EMT cells, effect on under treatment remains to be determined. Here, we showed dose-dependently stimulated by MCF-7 with maximal at 50 ng/ml. Meanwhile, markedly increased activation. was...
Aims and hypothesis: This study aims to investigate the mechanism involved in intracellualr regulation of EGFR degradation induced by EGF Methods: Phosphorylation proteins related signaling was examined western blot analysis. Activation, connection Rab35 interference with folliculin (FLCN) were assessed pulldown, coimmunoprecipitation assays separately. The relationship between FLCN cell growth detected using gene overexpression knock-down techniques. Results: FLCN, a tumor suppressor,...
Abstract NVP-BEZ235 (BEZ235), an available dual PI3K/mTOR inhibitor, showed antitumor effect and provided a therapy strategy in carcinomas. However, the acquired upregulation of multiple receptor tyrosine kinases (RTKs) by tumors limits its clinical efficacy. HDAC6, class II histone deacetylase, is associated with expressions RTKs. The aim this study was to detect whether co-treatment HDAC6 inhibitor Tubastatin A (TST) would enhance anticancer effects BEZ235 breast cancer cells. In study, we...
Various factors are known to regulate cell growth and differentiation in epithelial-mesenchymal interactions. Keratinocyte factor (KGF), an epithelial-specific cytokine produced by dermal fibroblasts other mesenchymal cells, appears affect growth, migration, We have previously shown that human embryonic skin induce anchorage-independent of HPV16 DNA-immortalized uterine exocervical epithelial cells (HCE16/3 line) cocultures HCE16/3 fibroblasts. Here we report KGF may be a major influencing...
Resveratrol is converted to various metabolites by gut microbiota. Human and rat liver 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) are critical for glucocorticoid activation, while 11β-HSD2 in the kidney does opposite reaction. It still uncertain whether resveratrol its analogues selectively inhibit 11β-HSD1. In this study, inhibitory strength, mode of action, structure–activity relationship (SAR), docking analysis on human, rat, mouse 11β-HSD1 were performed. The strength these chemicals...
There is an increasing demand for prenatal paternity testing in the forensic applications, which identify biological fathers before birth of children. Currently, one most effective and safe Non-Invasive Prenatal Paternity Testing (NIPPT) methods high-throughput Next-Generation Sequencing (NGS)-based SNP genotyping cell-free DNA maternal peripheral blood. To best our knowledge, nearly all being used such applications are based on traditional postnatal tests and/or statistical models...
1557 Background: Cancers of the gastrointestinal (GI) system, including esophagus, stomach, pancreas, gallbladder, liver, bile duct, colon, and rectum are estimated to account for 38% all cancer incidences nearly 46% cancer-related deaths in China. We conducted a multi-center study evaluate feasibility using genetic epigenetic abnormalities plasma cfDNA diagnose locate GI cancers. Methods: performed parallel profiling from hepatocellular carcinoma (HCC), colorectal (CRC) pancreatic (PC)...
Abstract Liver cancer is the second leading cause of cancer-related death in China and worldwide, where hepatocellular carcinoma (HCC) represents major histological type. Previous studies have demonstrated that surveillance program combining serum marker AFP ultrasound could greatly reduce liver mortality. However, it widely recognized has lower sensitivity for early stage disease specificity also sub-optimal, limiting its application detection timely intervention. Tumor-originated...
To investigate the expression of G-quadruplex antibody BG4 in human gastric cancer AGS cells and assess its functions attenuating proliferation promoting apoptosis cancer.BG4 high-expression cell line was established by pEGFP-N1-BG4 transient transfection. transfected with pEGFP-N1 plasmids were included into group those not negative control group. Cell counting kit-8 (CCK8) assay performed to examine ability, while flow cytometry used detect cycle distribution apoptosis. migration measured...