A5101791479- Liver Disease Diagnosis and Treatment
- Kawasaki Disease and Coronary Complications
- Cerebrovascular and Carotid Artery Diseases
- MRI in cancer diagnosis
- Hepatocellular Carcinoma Treatment and Prognosis
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Coronary Artery Anomalies
- Cardiovascular Health and Disease Prevention
- Radiomics and Machine Learning in Medical Imaging
- Intracerebral and Subarachnoid Hemorrhage Research
- Cardiomyopathy and Myosin Studies
- Pulmonary Hypertension Research and Treatments
- Liver Disease and Transplantation
- Hepatitis C virus research
- Cardiovascular Issues in Pregnancy
- Neurological Disease Mechanisms and Treatments
- Cardiovascular Function and Risk Factors
- Cardiovascular and Diving-Related Complications
- Acute Ischemic Stroke Management
- Traditional Chinese Medicine Analysis
- Cardiac Valve Diseases and Treatments
- Congenital Diaphragmatic Hernia Studies
- Cardiac Structural Anomalies and Repair
- Lipid metabolism and disorders
Huazhong University of Science and Technology
2006-2025
Henry Ford Hospital
2022-2025
Zhengzhou University
2025
China Medical University
2011-2024
Huangshan University
2024
Weatherford College
2024
Chengdu Second People's Hospital
2024
Second Hospital of Hebei Medical University
2024
Liuyang City Maternal and Child Health Hospital
2018-2024
Guangdong Province Environmental Monitoring Center
2024
The goal of this study was to evaluate the 5-year follow-up data IN.PACT DEEP (Randomized Amphirion Drug-Coated Balloon [DCB] vs. Standard Percutaneous Transluminal Angioplasty [PTA] for Treatment Below-the-Knee Critical Limb Ischemia [CLI]) trial.Initial studies from randomized controlled trials have shown comparable short-term outcomes DCB angioplasty versus PTA in patients with CLI infrapopliteal disease. However, long-term safety and effectiveness remain unknown patient...
Disruptions in brain-derived neurotrophic factor (BDNF) expression are proposed to contribute the molecular pathogenesis of Rett syndrome (RTT), a severe neurological disorder caused by loss-of-function mutations methyl-CpG-binding protein-2 (MeCP2). Although MeCP2 is transcriptional regulator BDNF, it unknown how affect transynaptic BDNF signaling. Our findings demonstrate an early, abnormal neurosecretory phenotype MeCP2-deficient neurons characterized significant increases percentage...
We examined the role that enzymatic protein O-GlcNAcylation plays in development of diabetic cardiomyopathy a mouse model Type 2 diabetes mellitus (DM2). Mice injected with low-dose streptozotocin and fed high-fat diet developed mild hyperglycemia obesity consistent DM2. Studies were performed from 1 to 6 mo after initiating DM2 protocol. After mo, mice showed increased body weight, impaired fasting blood glucose, hyperinsulinemia. Echocardiographic evaluation revealed left ventricular...
As insulin's movement from plasma to muscle interstitium is rate limiting for its metabolic action, defining the regulation of this critical. Here, we address whether caveolin-1 required first step transendothelial transport, uptake by vascular endothelial cells (ECs), and IL-6 TNFα affect insulin or expression. Uptake FITC-labeled was measured using confocal microscopy in control bovine aortic ECs (bAECs), bAECs which either knocked down overexpressed, murine −/− mice exposed inflammatory...
To survey and evaluate the prevalence potential risk factors of female urinary incontinence (UI) in Beijing, China.A population-based cross-sectional study was performed from April to July 2005. We randomly sampled 1.0% residents aged 20 years older year 2000 national census data, totaling 5,300 women. All women were interviewed face using a modified questionnaire based on International Consultation Incontinence Questionnaire-Female Lower Urinary Tract Symptoms. Data collected analyzed.The...
// Yujie Zhang 1, 2, 3 , Jun Du Jianchao Zheng Jiaojing Liu 2 Rui Xu 4 Tian Shen Yichao Zhu Chang Hong Wang Zhihong 5 Fanqing Meng 6 Yan 7 Yongchang Chen 8 Yong 9 Luo Gu 1 Cancer Center, Nanjing Medical University, Nanjing, Jiangsu 210029, China Department of Biochemistry and Molecular Biology, Physiology, Biotechnology, Pathophysiology, the First Affiliated Hospital Drum Tower University School, 210008, Second 210011, School Science Laboratory Medicine, Zhenjiang, 212013, Correspondence to:...
We aimed to investigate the relationship of time-averaged on-treatment systolic blood pressure (SBP) with risk first stroke in CSPPT (China Stroke Primary Prevention Trial). A post hoc analysis was conducted using data from 17 720 hypertensive adults without cardiovascular disease, diabetes mellitus, and renal function decline CSPPT, a randomized double-blind controlled trial. The primary outcome stroke. Over median follow-up duration 4.5 years, association between averaged SBP for stoke...
The aim of the present study was to compare diagnostic values ultrasound micro-flow imaging (SMI) and contrast-enhanced (CEUS) for neovascularization in carotid plaques, investigate their capacities predicting risks cerebral stroke. A total 39 patients (64 plaques) with severe artery stenosis undergoing endarterectomy were selected between February 2015 2016, SMI CEUS used detect plaques. According dynamic graph enhanced intensity visual scales contrast parameters obtained. Carotid...
Human bone marrow stem cells (hBMSCs) play an important role during the fracture healing phase. Previous clinical studies by our research group found that time was obviously delayed in patients who underwent splenectomy, for combined traumatic fractures and splenic rupture, which is most likely related to dysregulation of immune inflammatory function body after splenectomy. A large number have reported factor interleukin-1β plays multi-directional differentiation ability regulation BMSC, but...
Background and Objective: Acute type A aortic dissection (ATAAD) represents a critical life-threatening condition requiring urgent surgical intervention, which is often life-saving. However, postoperative acute lung injury (ALI) has emerged as prominent complication that significantly impacts patient outcomes prognosis. This study aims to systematically analyze the risk factors associated with development of severe ALI following ATAAD surgery, providing insights improve management...
Comorbid and anatomic characteristics that portend higher procedural risk are well defined for carotid endarterectomy but less so artery stenting.We pooled stent data from 4 Cordis-sponsored trials (n=2104) with similar patient cohorts end point determination to identify predictors of neurological death or stroke within 30 days the procedure. Median age was 74 years (24% >80 years), 36% were women, 24.2% symptomatic in previous 6 months. There 88 (4.2%) deaths strokes at days. Among...
The present study aimed to explore the possible radioprotective effects of celastrol and relevant molecular mechanisms in an vitro cell vivo mouse models exposed gamma radiation. Human keratinocytes (HaCaT) foreskin fibroblast (BJ) cells were radiation 20 Gy, followed by treatment with for 24 h. Cell viability, reactive oxygen species (ROS), nitric oxide (NO) glutathione (GSH) production, lipid peroxidation, DNA damage, inflammatory cytokine levels, NF-κB pathway activation examined....
Abstract Objectives To evaluate parameters of diffusion-weighted imaging (DWI) and dynamic contrast-enhanced magnetic resonance (DCE-MRI) as early indicators tumor histologic response to pre-operative neoadjuvant chemotherapy probable prognostic factors for event-free survival (EFS) overall in osteosarcoma (OS) both tumoral peritumoral areas. Methods Thirty-four OS patients who received three courses followed by surgery during 2014–2018 were enrolled this study. All underwent baseline...
BACKGROUNDIn clinical practice, the diagnosis is sometimes difficult with contrast-enhanced ultrasound (CEUS) when case has an atypical perfusion pattern.Color parametric imaging (CPI) analysis software for CEUS better detection of temporal differences in using arbitrary colors.It measures arrival time contrast agent lesions so that features hemangioma and colorectal cancer (CRC) liver metastasis can be distinguished. AIMTo evaluate role a novel type CPI differential from metastases patients...
Naoxintong (NXT), a prescribed traditional Chinese medicine, widely used in cerebrovascular and cardiovascular diseases, could be effective diabetic wounds.This study evaluates the wound healing activity of NXT by employing an excisional splinting model.NXT was dissolved saline given daily gavage. Wounds were induced at dorsum non-diabetic (db/+) (db/db) mice treated with or 700 mg/kg/d for 16 days. Wound closure measured every four Extracellular matrix (ECM) remodelling, collagen...
Hepatic angiomyolipoma (HAML) is a rare mesenchymal tumor of the liver with marked histological diversity. The present study was to review magnetic resonance imaging (MRI) and clinical pathological features HAML resembling hepatocellular carcinoma (HCC). Nine patients who underwent surgical resection had diagnosis were retrospectively analyzed. All 9 (5 males 4 females) solitary hepatic mass median size cm (from 1.4 15.3 cm). Seven cases identified as incidental tumors during health...
High NaCl in the renal medullary interstitial fluid powers concentration of urine but can damage cells. The transcription factor nuclear activated T cells 5 (NFAT5) activates expression osmoprotective genes. We studied whether PKC-α contributes to activation NFAT5. protein abundance was greater medulla than cortex. Knockout reduced NFAT5 and its target genes inner medulla. In human embryonic kidney (HEK)-293 cells, high increased activity, small interfering RNA-mediated knockdown attenuated...
Background: In patients with pulmonary arterial hypertension (PAH), mast cells (MCs) are extensively observed around vessels. However, their temporal and spatial variation during PAH development remains obscure. This study investigated the dynamic evolution of MCs in lungs right ventricles (RV) to illuminate role vascular RV remodeling. Methods: The model was established by a single intra-peritoneal injection monocrotaline (MCT, 60 mg/kg) rats. On day 0, 3, 7, 14, 28 after MCT injection,...