A5103028157- Cervical Cancer and HPV Research
- Cancer Immunotherapy and Biomarkers
- Lymphoma Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Ferroptosis and cancer prognosis
- Chronic Lymphocytic Leukemia Research
- Biochemical Analysis and Sensing Techniques
- Cancer Genomics and Diagnostics
- Adipose Tissue and Metabolism
- Cerebrovascular and Carotid Artery Diseases
- Autophagy in Disease and Therapy
- Regulation of Appetite and Obesity
- Bacteriophages and microbial interactions
- Stroke Rehabilitation and Recovery
- Reproductive tract infections research
- Genital Health and Disease
- Endometrial and Cervical Cancer Treatments
- Prenatal Screening and Diagnostics
- SARS-CoV-2 and COVID-19 Research
- Pancreatic and Hepatic Oncology Research
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Global Cancer Incidence and Screening
- Colorectal and Anal Carcinomas
- Cancer therapeutics and mechanisms
Nanjing Medical University
2021-2024
Liaoning Cancer Hospital & Institute
2014-2024
China Medical University
2019-2024
Jilin University
2020-2024
Shaanxi Provincial People's Hospital
2020-2024
Shanxi Medical University
2020-2024
Dalian Medical University
2024
Institute of Biophysics
2022-2023
Chinese Academy of Sciences
2022-2023
Jilin Medical University
2020-2023
Abstract Background Colposcopy diagnosis and directed biopsy are the key components in cervical cancer screening programs. However, their performance is limited by requirement for experienced colposcopists. This study aimed to develop validate a Colposcopic Artificial Intelligence Auxiliary Diagnostic System (CAIADS) grading colposcopic impressions guiding biopsies. Methods Anonymized digital records of 19,435 patients were obtained from six hospitals across China. These included images,...
Immunotherapy for malignant tumors has made great progress, but many patients do not benefit from it. The complex intratumoral heterogeneity (ITH) hindered the in-depth exploration of immunotherapy. Conventional bulk sequencing masked intratumor complexity, preventing a more detailed discovery impact ITH on treatment efficacy. Hence, we initiated this study to explore at multi-omics spatial level and seek prognostic biomarkers immunotherapy efficacy considering presence ITH.
Immune checkpoint inhibitors combined with chemotherapy as a neoadjuvant therapy have been applied to the treatment of esophageal squamous cell carcinoma (ESCC). However, optimal regimen needs be further explored, particularly for older patients, and mechanisms by which immune inhibitor modulates evolution ESCC are unknown.In this single-arm phase 2 trial, patients resectable (stage II/III/IV without metastasis) were enrolled received nanoparticle albumin-bound (nab) paclitaxel two cycles...
Amyloid β (Aβ) has been established as a key factor for the pathological changes in brains of patients with Alzheimer's disease (AD), and cellular senescence is closely associated aging cognitive impairment. However, it remains blurred whether, AD brains, Aβ accelerates neuronal whether this senescence, turn, impairs function. This study aimed to explore expression senescence-associated genes hippocampal tissue from young aged 5XFAD mice their age-matched wild type (WT) determine senescent...
Abstract Human papillomavirus (HPV) infection which continues to be the most common sexually transmitted disease, has been identified as a major risk factor for cervical cancer. Therefore, it is very important understand and grasp distribution of HPV in Chinese population, make foundation development cancer vaccine China. An extensive search strategy was conducted multiple literature databases. All retrieved studies were screened by October 31, 2018. The prevalence analyzed using random...
Total neoadjuvant therapy (TNT) is the standard treatment for locally advanced rectal cancer, especially patients with high-risk factors. However, efficacy of TNT combined immunotherapy proficient mismatch repair (pMMR) cancer unknown.
Colposcopy plays an essential role in diagnosing cervical lesions and directing biopsy; however, there are few studies of the capabilities colposcopists medically underserved communities China. This study aims to fill this gap by assessing colposcopists' competencies
Cervical cancer is the most common gynecological malignancy and screening for risk factors with early detection has been shown to reduce mortality. In this study, we aimed analyze characteristics of human papillomavirus (HPV) infection precancerous lesions in women provide clinical evidence developing strategies prevent cervical women. Furthermore, evaluated influencing high-risk HPV infection. From April 2018 December 2021, 10,628 were recruited at Liaoning Cancer Hospital, Shenyang...
Pancreatic cancer is one of the most challenging types in clinical treatment worldwide. This study aimed to understand tumorigenesis mechanism and explore potential therapeutic targets for patients with pancreatic cancer. Single-cell data expression profiles samples normal tissues from multiple databases were included. Comprehensive bioinformatics analyses applied clarify tumor microenvironment identify key genes involved development. Immense difference cell was shown between samples. Four...
CaMKII has long been known to be a key effector for synaptic plasticity. Recent studies have shown that variety of modulators interact with the subunits regulate long-term potentiation (LTP) hippocampal neurons. However, whether non-coding RNAs modulate activity and affect plasticity is still elusive. Here, we identify previously uncharacterized RNA Carip functions as scaffold, specifically interacts CaMKIIβ, regulates phosphorylation α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid...
Objective To explore the impact of empowerment interventions based on cross-theory models self-management behavior, self-efficacy, and daily living abilities in middle-aged young stroke patients. Methods A single-blind randomized controlled trial design was adopted, selecting 10 4 patients hospitalized four neurology departments at a tertiary hospital Xian from April to October 2023 as study subjects. The were randomly divided into an intervention group 52 cases control cases. received...
1. Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015. CA J Clin. 2016;66(2):115-132. doi:10.3322/caac.21338. CrossRef Google Scholar
The unfavorable outcome of acute ischemic stroke (AIS) with large vessel occlusion (LVO) is related to clinical factors at multiple time points. However, predictive models used for dynamically predicting outcomes using clinically relevant preoperative and postoperative point variables have not been developed. Our goal was develop a machine learning (ML) model the dynamic prediction outcomes. We retrospectively reviewed patients AIS who underwent consecutive mechanical thrombectomy (MT) from...
Anaplastic lymphoma kinase (ALK) is a promising new target for therapy of certain cancers such as anaplastic large-cell (ALCL) and inflammatory myofibroblastic tumor (IMT). We have identified series novel pyridones inhibitors ALK by application stepwise process involving in vitro screening targeted library followed iterative template modification based on medicinal chemistry insights computational ranking virtual libraries. Using this process, we discovered ALK-selective with improved...
The aim of this study was to investigate the association between diabetes mellitus (DM), mainly type II, with metabolic syndrome (MS) and diabetic nephropathy (DN)/diabetic retinopathy (DR). Based on analysis prevalence MS, patients DM were divided into MS non-MS groups according presence or absence MS. correlation DN, DR certain factors, including gender, age, disease duration a family history analyzed. among 62.50%. DN 55.33% in group that 26.00%. positively correlated blood pressure,...