A5005865071- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- RNA modifications and cancer
- Cardiovascular Disease and Adiposity
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Lung Cancer Research Studies
- Nutritional Studies and Diet
- Galectins and Cancer Biology
- Neonatal Health and Biochemistry
- Peptidase Inhibition and Analysis
- Sustainability and Ecological Systems Analysis
- Obesity, Physical Activity, Diet
- Cytokine Signaling Pathways and Interactions
- Solar-Powered Water Purification Methods
- Phagocytosis and Immune Regulation
- Cancer-related Molecular Pathways
- Alcohol Consumption and Health Effects
- Blood Pressure and Hypertension Studies
- Immune cells in cancer
- Advancements in Battery Materials
- Membrane Separation Technologies
- Cancer therapeutics and mechanisms
- Bariatric Surgery and Outcomes
Hebei Medical University
2014-2025
Fourth Hospital of Hebei Medical University
2015-2025
Research Center for Eco-Environmental Sciences
2025
Chinese Academy of Sciences
2025
University of Chinese Academy of Sciences
2025
Gansu University of Traditional Chinese Medicine
2024
Nantong University
2020-2023
Shenyang Jianzhu University
2023
Hospital of Hebei Province
2016-2018
Solar water evaporation (SWE) has emerged as an appealing method for and salt recovery from hypersaline wastewater. However, different ions usually transfer accumulate uncontrollably during ion-water separation, making fractionalization impractical conventional SWE, the resulting mixed salts are hard to use still require significant costs disposal. To achieve reutilization, achieving ion-ion separation simultaneously crucial in advancing SWE toward sustainability. Here, we present a...
Pancreatic cancer is one of the most challenging types in clinical treatment worldwide. This study aimed to understand tumorigenesis mechanism and explore potential therapeutic targets for patients with pancreatic cancer. Single-cell data expression profiles samples normal tissues from multiple databases were included. Comprehensive bioinformatics analyses applied clarify tumor microenvironment identify key genes involved development. Immense difference cell was shown between samples. Four...
Esophageal squamous cell carcinoma (ESCC) is one of the most common digestive malignancies. Our previous studies revealed necroptosis-related lncRNA ENSG00000253385.1 was an independent prognostic factor for ESCC. However, specific regulatory mechanisms are unknown. This study aimed to investigate expression in ESCC tissues and its relationship with clinicopathological features patient prognosis, explore potential mechanism cells. We detected location cells by fluorescence situ hybridization...
Abstract Background Obesity is associated with type 2 diabetes mellitus (T2DM). However, the obesity index that most closely related to remains controversial. Therefore, aim of this study was compare associations five anthropometric indices (body mass [BMI], body adiposity index, waist circumference [WC], waist-to-hip ratio, and waist-to-height ratio [WHtR]) T2DM among Chinese adults divided into four groups according sex age. Methods A total 4007 adult participants (1669 men 2338 women)...
The present study aimed to investigate the value of apolipoproteins, including ApoA-1, ApoC-III, and ApoE, in patients with small cell lung cancer (SCLC) as potential biomarkers for diagnosis, prognosis, progression.Lung samples were collected from 89 SCLC. Nineteen non-small (NSCLC) 12 normal tissues used controls. Expression profiles ApoE different examined using immunohistochemical methods, expression levels correlated types, treatment, outcomes chi-square Mann-Whitney tests.Expression...
Abstract Background Improving immunotherapy efficacy for EGFR‐negative lung adenocarcinoma (LUAD) patients remains a critical challenge, and the therapeutic effect of is largely determined by tumor microenvironment (TME). Tumor‐associated macrophages (TAMs) are top‐ranked immune infiltrating cells in TME, M2‐TAMs exert potent roles promotion chemotherapy resistance. An M2‐TAM‐based prognostic signature was constructed integrative analysis single‐cell RNA‐seq (scRNA‐seq) bulk data to reveal...
The crucial roles of the long noncoding RNAs (lncRNAs) in development ovarian cancer (OC) have been extensively studied. According to prediction result from Kaplan-Meier Plotter database, high expression lncRNA proteasome subunit α type-3 antisense RNA1 (PSMA3-AS1) is associated with poor prognosis patients OC. Thus, study aimed investigate role PSMA3-AS1 Reverse transcription quantitative polymerase chain reaction analysis revealed that was significantly upregulated OC cells and tissues....
Esophageal carcinoma (ESCA) is one of the most common malignancies in world, and has high morbidity mortality rates. Necrosis long noncoding RNAs (lncRNAs) are involved progression ESCA; however, specific mechanism not been clarified. The aim present study was to investigate role necrosis-related lncRNAs (nrlncRNAs) patients with ESCA by bioinformatics analysis, establish a nrlncRNA model predict immune infiltration prognosis. To form synthetic matrices, transcriptome data related...
Abstract Background The dominant subclass of non‐small‐cell lung cancer (NSCLC) is adenocarcinoma (LUAD). tumor microenvironment (TME) a crucial feature carcinogenesis and progression in LUAD. Furthermore, immune stromal components TME are factors to investigating curing Thus, the study assessed value TME‐related genes for LUAD prognosis infiltration. Methods All data were downloaded from TCGA GEO databases. scores ESTIMATE, association between was explored by Kaplan–Meier survival analysis....
Previous studies have shown that necroptosis-related long noncoding RNA (lncRNA) risk models can be used to predict prognosis and immune infiltration in patients with esophageal cancer. However, further analysis of the regulatory mechanisms lncRNAs remains conducted. The purpose present study was identify valuable cancer verify their molecular cellular functions.
Elevated bilirubin has been associated with protection of cardiovascular and kidney systems, whereas decreased may predispose respiratory diseases. However, whether serum levels are lung cancer remains unclear. Here, clinical pathologic data a cohort 363 patients along age-and gender-matched healthy subjects were collected. The association was analyzed. significantly lower in patients. aspartate transaminase alkaline phosphatase higher cancer. Multi-classification logistics regression...
Glioma is a prevalent malignancy among brain tumors with high modality and low prognosis. Ferroptosis has been identified to play crucial role in the progression treatment of cancers. KAT6B, as histone acetyltransferase, involved multiple cancer development. However, function KAT6B glioma still elusive. Here, we aimed evaluate effect on ferroptosis cells explored potential mechanisms. We observed that expression was enhanced clinical samples. The viability repressed by erastin overexpression...
Esophageal squamous cell carcinoma (ESCC) is a common malignancy with high morbidity and mortality. Although circular RNAs (circRNAs) play important roles in various cancers including ESCC, the role of circRNA mannosidase alpha class 1A member 2 (circMAN1A2) ESCC has been rarely studied. This study aimed to explore circMAN1A2 ESCC. CircMAN1A2 expression tissues cells was evaluated, relationship between prognosis patients analyzed. C–C chemokine ligand 5 (CCL5) found be downstream target by...
Interleukin-27 (IL-27) has been recognized as a pleiotropic cytokine with both pro- and anti-inflammatory properties. However, there are no data about the role of IL-27 polymorphism in development cervical cancer. A hospital-based case–control study was conducted 380 patients cancer healthy controls to investigate possible associations gene polymorphisms (−964A/G, 2905T/G, 4730T/C), susceptibility clinical outcome. Our results suggested that 2905T/G significantly associated decreased risk...
Breast cancer is among the most common causes of cancer-related death in women worldwide. Previous studies have demonstrated an association between prolonged estrogen exposure and increased risk breast cancer. Uridine 5'-diphospho-glucuronosyltransferase 1-1 (UGT1A1) plays a significant role detoxification estrogens. Two major genetic polymorphisms been identified UGT1A1 locus. UGT1A1*28 has previously linked to The aim this study was elucidate possible correlation UGT1A1*6, single...
e21104 Background: Angiogenesis plays a critical role in the growth, progression, and metastasis of numerous solid tumor types. Apatinib is tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor 2 (VEGFR2), which inhibits angiogenesis. Etoposide plus cisplatin standard chemotherapy regimen for Extensive-Stage Small-Cell Lung Cancer (SCLC). Combining apatinib with may have synergistic effect improve efficacy. Methods: Eligible patients were adults histologically or...