A5060438882- Ferroptosis and cancer prognosis
- Biometric Identification and Security
- RNA modifications and cancer
- Lung Cancer Diagnosis and Treatment
- Advanced Chemical Sensor Technologies
- Cancer Immunotherapy and Biomarkers
- Histone Deacetylase Inhibitors Research
- Mesenchymal stem cell research
- Optical Coherence Tomography Applications
- Lung Cancer Treatments and Mutations
- Insect Pheromone Research and Control
- Tissue Engineering and Regenerative Medicine
- Immune cells in cancer
- Cardiac Fibrosis and Remodeling
- Cancer, Stress, Anesthesia, and Immune Response
- GDF15 and Related Biomarkers
- Cancer Mechanisms and Therapy
- Mechanisms of cancer metastasis
- Macrophage Migration Inhibitory Factor
- Retinal Imaging and Analysis
- Coastal and Marine Dynamics
- Epigenetics and DNA Methylation
- Electrospun Nanofibers in Biomedical Applications
- Cardiac, Anesthesia and Surgical Outcomes
- Peptidase Inhibition and Analysis
Tongji University
2022-2025
Shanghai Pulmonary Hospital
2022-2025
Air Force Engineering University
2025
Air Force Medical University
2025
University of Technology Sydney
2022-2024
Integrated Chinese Medicine (China)
2024
Shenzhen University
2022-2023
Shenzhen Academy of Robotics
2023
Shandong University
2023
Jiangsu University of Science and Technology
2023
Alterations in the tumor microenvironment are closely associated with metabolic phenotype of cells. Cancer-associated fibroblasts (CAFs) play a pivotal role growth and metastasis. Existing studies have suggested that lactate produced by cells can activate CAFs, yet precise underlying mechanisms remain largely unexplored. In this study, we initially identified derived from lung cancer promote nuclear translocation NUSAP1, subsequently leading to recruitment transcriptional complex...
The glycoprotein known as glomalin-related soil protein (GRSP) is abundantly produced on the hyphae and spores of arbuscular mycorrhizal fungi (AMF) in roots. Few studies have focused its amount, composition associations with properties possible land-use influences, although data hints at rehabilitation. By choosing a primary forest non-degraded reference, it to explore whether afforestation can improve degraded farmland by altering GRSP. In this paper, close correlations were found between...
Background: Recently, PANoptosis has aroused the interest of researchers for its role in cancers. However, studies that investigated lung cancer are still few. Methods: The public data were mainly collected from Cancer Genome Atlas (TCGA) and Gene Expression Omnibus database. R software was utilized analysis data. Quantitative real-time (qRT) polymerase chain reaction (PCR) used to measure RNA level FADD. cell proliferation ability evaluated using CCK8, colony formation,...
Cell lineage plasticity is one of the major causes for failure targeted therapies in various cancers. However, driver and actionable drug targets promoting cancer cell are scarcely identified. Here, we found that a G protein-coupled receptor, ADORA2A, specifically upregulated during neuroendocrine differentiation, common form prostate lung following therapies. Activation ADORA2A signaling rewires proline metabolism via an ERK/MYC/PYCR cascade. Increased synthesis promotes deacetylases...
Neural infiltration has been found in various cancers and the infiltrating nerves influence tumor growth dissemination. In non-small cell lung cancer, pan-neuronal marker PGP9.5 was detected by immunohistochemical staining its high expression correlated with poor prognosis. However, existence of nerve fibers mechanism driving neural remains unclear. We first used to assess density patients adenocarcinoma different sizes. Following that, we performed differential analysis univariate Cox...
Background/Aims: Adipose-derived stem cells (ASCs) belong to mesenchymal and may play a potential role as seeding in cell transplantation. To be able exploit therapeutic tool, their defects some important cellular functions, such low survival rate activity, should considered. This is especially the case for that are intended Of note, responses hormones considered since estrogen known critical behavior. However, different impacts of receptor (ER) types α β have not been fully determined ASC...
Abstract TGFβ1 signaling is a critical driver of collagen accumulation in pulmonary fibrotic diseases and well-characterized regulator cancer associated fibroblasts (CAF) activation lung cancer. Myofibroblasts induced by other factors are key players the pathogenesis fibrosis tumor. Tremendous attention has been gained to targeting myofibroblasts order inhibit progression myofibroblast-induced tumor metastasis. Here we determined therapeutic efficacy simultaneously PI3K HDAC pathways CAF...
Abstract The strain localization and crack initiation behavior of a powder metallurgy (PM) nickel‐based superalloy FGH4098 under low cycle fatigue (LCF) loads at room temperature is investigated by combining scanning electron microscope (SEM)‐digital image correlation (DIC) characterization with crystal plasticity simulation. elastic anisotropy near annealing twin boundaries contributes to results in high propensity LCF failure. effect local microstructure on the {111} slip bands tortuous...
Radiological manifestations of coronavirus disease 2019 (COVID-19) featured ground-glass opacities (GGOs), especially in the early stage, which might create confusion differential diagnosis with lung cancer. We aimed to specify radiological characteristics COVID-19 and cancer unveil discrepancy between them.One hundred fifty-seven patients 374 from four hospitals China were retrospectively enrolled. Epidemiological, clinical, radiological, pathological compared two groups using propensity...
Abstract OBJECTIVES Preoperative selection bias led to the inability generalize proposed benefit of subxiphoid uniportal video-assisted thoracoscopic surgery (SVATS) as having less postoperative pain than intercostal VATS. So, we conducted this prospective, single-blinded, randomized controlled trial investigate hypothesis that SVATS may have early UVATS in patients who undergo major lung resection for early-stage cancer. METHODSA total 262 were randomly allocated between 2 groups (each with...
PI3K-Akt pathway activation and the expression of histone deacetylases (HDACs) are highly increased in esophageal cancer, suggesting that inhibition such targets may be a viable therapeutic strategy. Herein, we aimed to evaluate anti-tumor effect CUDC-907, dual PI3K-HDAC inhibitor, squamous cell carcinoma (ESCC). The effects CUDC-907 ESCC were evaluated using counting kit-8, flow cytometry, western blot. mRNA-sequencing was used explore mechanism underlying effects. relations reactive oxygen...
Social capital is a multidimensional concept including social trust, support, participation, and reciprocity, each dimension may be associated with the cognition of older adults differently. The existing research on rarely constructs comprehensive framework compares association between multiple dimensions capital. To determine whether four domains have different associations among in China. Baseline four-year follow-up data (N = 6291) from community-dwelling participants aged ≥55 years at...
The search for missing persons is a major challenge investigations involving presumed deceased individuals. Currently, the most effective tool use of cadaver-detection dogs; however, they are limited by their cost, operation times, and lack granular information reported to handler. Thus, there need discrete, real-time detection methods that provide searchers explicit as whether human-decomposition volatiles present. A novel e-nose (NOS.E) developed in-house was investigated detect...
This study explores the role of cross-attention during inference in text-conditional diffusion models. We find that outputs converge to a fixed point after few steps. Accordingly, time convergence naturally divides entire process into two stages: an initial semantics-planning stage, which, model relies on plan text-oriented visual semantics, and subsequent fidelity-improving which tries generate images from previously planned semantics. Surprisingly, ignoring text conditions stage not only...
This study aimed to demonstrate the learning curve of robot-assisted minimally invasive esophagectomy (RAMIE). A retrospective analysis first 124 consecutive patients who underwent RAMIE with intrathoracic anastomosis (Ivor Lewis) by a single surgeon between May 2015 and August 2020 was performed. An risk-adjusted cumulative sum (RA-CUSUM) applied generate considering major complication rate, which reflected technical proficiency. The overall 30-day morbidity rate 38.7%, while 25.8%. divided...
Abstract Background Cancer‐associated fibroblasts (CAFs) have been reported to play a crucial role in the tumor microenvironment and progression. Methods The data used this study were obtained from Cancer Genome Atlas Gene Expression Omnibus databases, all analyses performed using R software. Results We first quantified CAFs infiltration through single sample gene set enrichment analysis TCGA combined GEO cohort (GSE30219, GSE37745, GSE50081). Our result showed that patients with high levels...
Astragalin (AG), a natural flavonoid present in white mulberry and plants belonging to Rosaceae other families, has various biological functions. However, the potential mechanism through which it protects liver from injury caused by oxidative stress not yet been reported. In this study, we aimed elucidate underlying hepatoprotective effect of AG. We found that AG treatment inhibited H2O2 promoted Nrf2 nuclear translocation an LO2 cell model. Furthermore, expression its downstream antioxidant...
The air environment (e.g., high concentration of carbon dioxide) in a pig house will affect the health conditions and growth performance pigs, quality pork as well. In order to reduce cumulative dioxide house, prediction model was established by deep learning method predict changes house. This also be used for real-time monitoring adjustment experiment designed collect environmental parameters temperature, humidity, wind speed, concentration) data several months. ensemble empirical mode...