A5101617784- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer-related gene regulation
- T-cell and B-cell Immunology
- Lung Cancer Treatments and Mutations
- Bioactive natural compounds
- Immune Cell Function and Interaction
- Endoplasmic Reticulum Stress and Disease
- Cancer-related molecular mechanisms research
- Congenital Diaphragmatic Hernia Studies
- Immune cells in cancer
- Glycosylation and Glycoproteins Research
- Gut microbiota and health
- Circular RNAs in diseases
- Pain Mechanisms and Treatments
- Phagocytosis and Immune Regulation
- Cell death mechanisms and regulation
- MicroRNA in disease regulation
- Autophagy in Disease and Therapy
- Pharmacological Effects of Natural Compounds
- Ginger and Zingiberaceae research
- PI3K/AKT/mTOR signaling in cancer
- Fluoride Effects and Removal
- Ginseng Biological Effects and Applications
- Biochemical and Structural Characterization
Xi'an Medical University
2024
Inje University
2019-2024
Cangzhou Central Hospital
2024
Nantong University
2009-2022
Lanzhou University
2022
The Ohio State University
2022
China-Japan Friendship Hospital
2022
Ruijin Hospital
2020
Shanghai Jiao Tong University
2020
The Affiliated Yongchuan Hospital of Chongqing Medical University
2020
Despite optimal and early surgical treatment of non-small-cell lung cancer (NSCLC), many patients die recurrent NSCLC. We investigated the association between gene methylation recurrence tumor.Fifty-one with stage I NSCLC who underwent curative resection but had a within 40 months after (case patients) were matched on basis age, stage, sex, date surgery to 116 did not have (controls). whether seven genes in tumor lymph nodes was associated recurrence.In multivariate model, promoter...
Abstract Purpose: Histologically positive bronchial margins after resection for non-small cell lung cancer are associated with shortened patient survival due to local recurrence. We hypothesized that DNA promoter hypermethylation changes at could be detected in patients no histological evidence of malignancy and they would reflect epigenetic events the primary tumor. Experimental Design: Bronchial margins, tumor, bronchoalveolar fluid, paired nonmalignant were obtained from 20 who underwent...
Abstract Purpose: In lung cancer, DNA hypermethylation is known to be a common event. Experimental Design: Gene expression and methylation status of GATA-4, GATA-5, GATA-6 were analyzed with cell lines primary human cancers. Methylation profiles cancers correlated clinical as well histopathological data. Results: Complete was detected by methylation-specific PCR for both GATA-4 GATA-5 in four (H358, DMS-53, A549, H1299), all which had no reverse transcription-PCR analysis. Demethylation...
Oral squamous cell carcinoma (OSCC) is a genetic and epigenetic disease. There growing evidence to suggest that environmental factors due changes can be involved in the OSCC pathogenesis. Although tumor suppressor genes (TSGs) are commonly inactivated by promoter hypermethylation human cancers, mechanism of TSGs remain unclear. We therefore assessed methylation status TSGs, which associated with silencing lines, primary tumors, normal oral mucosa. used 14 were originally identified colon...
Cisplatin (CDDP) and its derivatives are first line anti-cancer drugs for ovarian cancer (OVCA). However, chemoresistance due to high incidence of p53 mutations leads poor clinical prognosis. Saikosaponin-d (Ssd), a saponin from herbal plant extract, has been shown induce cell death sensitize chemoresistant cells chemotherapeutic agents. Here, we demonstrated that Ssd sensitized OVCA with either p53-wt, -mutant -null CDDP. The action appears be through induction mitochondrial fragmentation...
Regulating cardiac differentiation to maintain normal heart development and function is very important. At present, biological functions of H19 in not completely clear. To explore the functional effect during differentiation. Expression levels early cardiac-specific markers Nkx-2.5 GATA4, contractile protein genes α-MHC MLC-2v were determined by qRT-PCR western lot. The lncRNA miR-19b detected qRT-PCR. We further predicted binding sequence online softwares starBase v2.0 TargetScan. Sox6...
Abstract TGFβ1 signaling is a critical driver of collagen accumulation in pulmonary fibrotic diseases and well-characterized regulator cancer associated fibroblasts (CAF) activation lung cancer. Myofibroblasts induced by other factors are key players the pathogenesis fibrosis tumor. Tremendous attention has been gained to targeting myofibroblasts order inhibit progression myofibroblast-induced tumor metastasis. Here we determined therapeutic efficacy simultaneously PI3K HDAC pathways CAF...
Organically modified silica (ORMOSIL) nanoparticles (NPs) are widely used in biomedicine. However, their cell uptake process has not yet been characterised detail. Here, we investigated the mechanism underlying endocytosis and subcellular localisation of ORMOSIL NPs. Exposure to NPs induced a decrease viability increase lactate dehydrogenase release dose-dependent manner A549 cells. Once internalised, were translocated from early endosomes lysosomes, where they accumulated. Furthermore,...
Abstract Background Environmental exposure, medical diagnostic and therapeutic applications, industrial utilization of radionuclides have prompted a growing focus on the risks associated with low-dose radiation (< 100 mGy). Current evidence suggests that such can induce epigenetic changes. Nevertheless, whether exposure to disrupt endothelial cell function at molecular level is unclear. Because cells play crucial roles in cardiovascular health disease, we aimed investigate could lead...
5-Hydroxytryptophan (5HTP), an analogue of tryptophan, is a precursor serotonin that also has effective antioxidative and anti-apoptotic properties (1). However, the cellular mechanisms underlying these 5HTP have not been explored. In this study, we tested hypothesis exerts its action against oxidative stress inflammation by suppressing activation key pro-inflammatory transcriptional pathways, p38 mitogen-activated protein kinase (p38MAPK) nuclear factor-κB (NF-κB). The study was carried out...
Hypoxia is associated with resistance to anticancer therapies. Additionally, it involved in the immune evasion of cancer cells by inducing an immunosuppressive microenvironment. However, role hypoxia modulating immunogenicity remains unknown. known induce endoplasmic reticulum (ER) stress, which serves a key cell surface exposure calreticulin, marker immunogenic death. The present study investigated whether influenced using FACS, western blot analysis and syngenic mouse tumor model. results...
Background/Aims: Overwhelming evidence suggests that inflammatory bowel disease (IBD) is caused by a complicated interplay between the multiple genes and abnormal epigenetic regulation in response to environmental factors. It becoming apparent factors are significantly associated with development of disease. DNA methylation remains most studied modification, hypermethylation gene promoters silencing.Methods: alterations may contribute many complex diseases regulating external internal...
Background: Post-stroke depression (PSD) is one of the most common complications in stroke survivors. But, there are still no objective methods to diagnose PSD. This study aims identify potential biomarkers for diagnosing PSD middle-aged Methods: Middle-aged subjects aged 30 59 years (92 patients and 89 survivors without depression) were included this study. Urinary metabolites detected by gas chromatography-mass spectrometry (GC-MS). Differential urinary screened applying statistical...
Inflammatory bowel disease is known to be associated with a genetic predisposition involving multiple genes; however, there growing evidence that abnormal interactions environmental factors, particularly epigenetic can also significantly contribute the development of inflammatory (IBD). Although many genome-wide association studies have been performed identify changes underlying pathogenesis Crohn's disease, role alterations based on molecular complications arising from (CD) poorly...
Growing evidence suggests that genetic and epigenetic factors, including environmental contribute to the development of oral squamous cell carcinoma (OSCC). Here, we investigated transcriptional silencing CD24, CD44, CD133, CD147 genes, which are well-known cancer stem surface markers in various types, OSCC. We first examined correlation between expression level reactivation by 5-aza-2′-deoxycytidine (5-aza-dC) promoter methylation levels four genes several OSCC lines. observed...