A5100707758- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Health and Wellbeing Research
- Pediatric health and respiratory diseases
- Wireless Communication Networks Research
- Advanced Wireless Communication Techniques
- Food Quality and Safety Studies
- Chemical Synthesis and Reactions
- Natural product bioactivities and synthesis
- Respiratory and Cough-Related Research
- Healthcare and Venom Research
- Nutrition, Health and Food Behavior
- Diverse Approaches in Healthcare and Education Studies
- Pluripotent Stem Cells Research
- Pancreatic function and diabetes
- Advanced Wireless Network Optimization
- Carbon Nanotubes in Composites
- Pharmacological Effects of Natural Compounds
- Dermatology and Skin Diseases
- Synthesis and Catalytic Reactions
- Synthesis and Characterization of Heterocyclic Compounds
- Mast cells and histamine
- Ginseng Biological Effects and Applications
- Asymmetric Synthesis and Catalysis
- Adipose Tissue and Metabolism
Korea Institute of Oriental Medicine
2016-2025
Inha University
2003-2024
Chonnam National University
2006-2024
University of Wisconsin–Madison
2020-2023
National Cancer Center
2012-2023
Hanyang University
2008-2023
Konkuk University
2023
Mokpo National University
2016-2022
Catholic University of Korea
2021
Pukyong National University
2011-2020
Abstract Lycopene ϵ‐cyclase ( LCY ‐ϵ ) is involved in the first step of α‐branch synthesis pathway carotenoids from lycopene plants. In this study, to enhance carotenoid via β‐branch‐specific [which yields β‐carotene and abscisic acid (ABA)] sweetpotato, expression IbLCY was downregulated by RNAi (RNA interference) technology. The ‐ vector constructed using a partial cDNA sweetpotato isolated storage root introduced into cultured cells Agrobacterium ‐mediated transformation. Both...
Reverse transcription quantitative real-time PCR (RT-qPCR) has become one of the most widely used methods for gene expression analysis, but its successful application depends on stability suitable reference genes data normalization. In plant studies, choice and optimal number must be experimentally determined specific conditions, species, cultivars. this study, ten candidate sweetpotato (Ipomoea batatas) were isolated their was analyzed using two algorithms, geNorm NormFinder. The samples...
The R2R3-type protein IbMYB1 is a key regulator of anthocyanin biosynthesis in the storage roots sweet potato [Ipomoea batatas (L.) Lam]. Previously, we demonstrated that expression stimulated pigmentation tobacco leaves and Arabidopsis. Here, generated dual-pigmented transgenic plants accumulated high levels both anthocyanins carotenoids single root. An orange-fleshed cultivar with carotenoid was transformed gene under control either root-specific sporamin 1 (SPO1) promoter or oxidative...
Mesenchymal stem cells (MSCs) are multipotent adult capable of differentiating along the osteoblast, adipocyte, and chondrocyte lineages. Regulation MSCs differentiation may be a useful tool for regenerative medicine cell-based therapy. The discovery small molecule that activates osteogenic could aid in development new anabolic drug osteoporosis treatment. We identified CW008, derivative pyrazole-pyridine, stimulates osteoblast human increases bone formation ovariectomized mice. CW008...
Nucleoside diphosphate kinase 2 (NDPK2) is known to regulate the expression of antioxidant genes in plants. Previously, we reported that overexpression Arabidopsis NDPK2 (AtNDPK2) under control an oxidative stress-inducible SWPA2 promoter transgenic potato and sweetpotato plants enhanced tolerance various abiotic stresses. In this study, poplar (Populus alba × Poplus glandulosa) expressing AtNDPK2 gene a (referred as SN) was generated develop with stress. The level NDPK activity SN following...
Osteogenesis is a tightly regulated process that involves coordinated extracellular signals from autocrine and paracrine loops. Secretory proteins during osteogenesis can inhibit cell proliferation activate differentiation toward mature osteoblasts, which are characterized by mineralization. In this study, we attempted to identify these secretory using LC-MS/MS analysis. We compared the secretome between undifferentiated human bone marrow-derived mesenchymal stem cells (hBMSCs)...
Neuronal precursor cells (NPCs) are temporally regulated and have the ability to proliferate differentiate into mature neurons, oligodendrocytes, astrocytes in presence of growth factors (GFs). In present study, role Jak pathway brain development was investigated NPCs derived from neurosphere cultures using Jak2 Jak3 small interfering RNAs specific inhibitors. inhibition profoundly decreased NPC proliferation, preventing further differentiation neurons glial cells. However, induced neuronal...
Arginine vasopressin (VP) is neurohypophysial hormone has been implicated in stimulating contractile activity of the male reproductive tract testis. Higher levels VP decrease sperm count and motility. However, very little known about involvement controlling mammalian process. The goal this study was to confirm that effect receptor (AVPR2) on function capacitation condition. Deamino [Cys 1, D-ArgS] (dDAVP), an AVPR2 agonist operates only AVPR2, used. Also, Mouse spermatozoa were incubated...
Wedelolactone is an herbal medicine that used to treat septic shock, hepatitis and venom poisoning. Although in differentiated cancer cells, wedelolactone has been identified as anti-inflammatory, growth inhibitory, pro-apoptotic, the effects of on stem cell differentiation remain largely unknown. Here, we report inhibits adipogenic human adipose tissue-derived mesenchymal cells (hAMSCs). reduced formation lipid droplets expression adipogenesis-related proteins, such CCAAT enhancer-binding...
The purpose of present study was to examine biological and psychological characteristics people according the Sasang typology, which is popular in Korea. We evaluated Personality Questionnaire (SPQ) as a measure temperament, Body Mass Index (BMI) somatic properties each type. Subjects were 2506 (877 males, 1629 females) outpatients between ages 20 through 70 who requested traditional medical assessment treatment structural validity SPQ examined its correlation with BMI analyzed. measures...
Anemarrhena asphodeloides has been widely used in traditional medicine for thousands of years; it reported to improve learning and memory, reduce inflammation. However, the role A. enhancing immune response remained unclear.This study aimed evaluate effect extract (AA-Ex) on macrophages identify active compounds causing these effects.To determine AA-Ex its compounds, cell proliferation cycle RAW 264.7 cells were analyzed by MTS assay flow cytometry. The gene expression p53, p27, cyclin D2,...
3′‐Phosphoinositide‐dependent kinase‐1 (PDK1) has been identified for its ability to phosphorylate and activate Akt. Accumulated studies have shown that the activation of PDK1/Akt pathway plays a pivotal role in cell survival, proliferation, tumorigenesis. Therefore, is believed be critical target cancer intervention. In this paper, we report discovery new function phenothiazines, widely known as antipsychotics, inhibiting pathway. Upon epidermal growth factor (EGF) stimulation,...
Patients with chronic granulomatous disease (CGD), whom inherit abnormal function of NADPH oxidase 2 (Nox2), suffer from hyperinflammatory responses in lung as well bacterial and fungal infection. There have been studies to reveal the Nox2 diseases, especially asthma, but exact role asthma is still unclear controversial. Therefore, we attempted clarify using various experimental models.Asthma phenotypes were analyzed response allergen-induced Nox2-deficient mice recombinase...
Atelectasis may play a substantial role in the development of pneumonia. However, pneumonia has never been evaluated as an outcome atelectasis surgical patients. We aimed to determine whether is related increased risk postoperative pneumonia, intensive care unit (ICU) admission and hospital length stay (LOS).The electronic medical records adult patients who underwent elective non-cardiothoracic surgery under general anesthesia between October 2019 August 2020 were reviewed. They divided into...
Effects of Dictamnus dasycarpus Turcz. on allergic asthma and their underlying mechanisms remain unclarified. Thus, we investigated the effects D. water extract (DDW) mucus hypersecretion in mice with ovalbumin (OVA)-induced human bronchial epithelial cells. BALB/c were used to establish an OVA-induced model. Mice grouped into OVA sensitization/challenge, 100 300 mg/kg DDW treatment, dexamethasone groups. In mice, cell counts bronchoalveolar lavage fluid (BALF), serum BALF analyses,...
This study examined the effects of high glucose on cell proliferation and its related signal pathways using mouse embryonic stem (ES) cells. Here, we showed that level significantly increased [3H]thymidine incorporation, BrdU number cells, [3H]leucine, [3H]proline incorporation in a time-( >3 hr) dose-(> 25 mM) dependent manner. Moreover, cellular reactive oxygen species (ROS), Akt, mitogen-activated protein kinases (MAPKs) phosphorylation. Subsequently, these signaling molecules involved...