A5100417560- Circadian rhythm and melatonin
- Click Chemistry and Applications
- Genetics, Aging, and Longevity in Model Organisms
- Covalent Organic Framework Applications
- Spectroscopy and Quantum Chemical Studies
- Metal-Organic Frameworks: Synthesis and Applications
- Molecular Sensors and Ion Detection
- Quantum, superfluid, helium dynamics
- Microfluidic and Capillary Electrophoresis Applications
- Superconductivity in MgB2 and Alloys
- Seedling growth and survival studies
- Hydrogen Storage and Materials
- Neuroendocrine regulation and behavior
- Photosynthetic Processes and Mechanisms
- Advanced Chemical Physics Studies
- Boron and Carbon Nanomaterials Research
- Quinazolinone synthesis and applications
- Plant-Derived Bioactive Compounds
- Tryptophan and brain disorders
- Nanoparticles: synthesis and applications
- Advanced biosensing and bioanalysis techniques
- Spaceflight effects on biology
- Metal-Catalyzed Oxygenation Mechanisms
- Analytical Chemistry and Sensors
- Analytical Chemistry and Chromatography
Institute for Basic Science
2015-2020
Yonsei Proteome Research Center
2017
Yonsei University
2017
Pusan National University Yangsan Hospital
2014
Pusan National University
2012
Inha University
2012
NanoScale Corporation (United States)
2009
University of Virginia
2007-2009
Pohang University of Science and Technology
2008
Massachusetts Institute of Technology
2007
Abstract Ageing is marked by physical decline. Caenorhabditis elegans a valuable model for identifying genetic regulatory mechanisms of ageing and longevity. Here we report simple method to assess C. ’ maximum ability based on the worms’ movement velocity. We show velocity declines with age, correlates well longevity, accurately reports and, if measured in mid-adulthood, predictive maximal lifespan. Contrary recent findings, observe that worm mutations daf-2(e1370) insulin/IGF-1 signalling...
Salt ions promote heterogeneous localization of charged molecules toward the interface aqueous microdroplets in oil.
3′‐Phosphoinositide‐dependent kinase‐1 (PDK1) has been identified for its ability to phosphorylate and activate Akt. Accumulated studies have shown that the activation of PDK1/Akt pathway plays a pivotal role in cell survival, proliferation, tumorigenesis. Therefore, is believed be critical target cancer intervention. In this paper, we report discovery new function phenothiazines, widely known as antipsychotics, inhibiting pathway. Upon epidermal growth factor (EGF) stimulation,...
The antibacterial and moisturizing effects inherent to silver nanoparticles contribute greatly their use as a topical agent. property of provides wounds with an indirect environment for healing through the prevention pathogenic infection. However, direct wound-healing have not been previously explored. In this work, we report bimodal therapeutic nanoparticle that possesses both properties. consist high-valence silver-pyridoxine complexes. efficacy was verified in diabetic mice, well vitro...
The adsorption and vibrational properties of chemisorbed HCN on Lewis acid sites, base Brønsted Al−OH sites a partially hydroxylated γ-Al2O3 surface have been obtained by combination FTIR density functional theory studies. modes from the molecular dissociative were assigned using deuterium 13C-labeled D13CN molecules at 170 K. In addition, η2(C, N)−HCN bonding is also found ν(CN) spectra. Good correlation calculated frequencies for adsorbed species with experimental data found. effect...
The influence of water vapor on the surface diffusion behavior pyridine adsorbed powdered MgO surfaces has been studied by Fourier transform IR (FTIR) absorption spectroscopy. It found that introduction significantly increases coefficient. FTIR spectra showed converted Lewis acid Mg2+ sites to Brønsted Mg−OH sites. These measurements also detected change in bonding two types activation energy for escape chemisorbed into a mobile precursor state is lower bound than binding sites, causing...
To prepare a versatile solid-state fluorescent sensor for chemical and biological applications is still challenge. In this report, we describe multifunctional nanosensor that capable of highly sensitive selective detecting the heavy metal ion Hg2+ in range pH from 4.0 to 6.6, probing α-amino acids by ion-mediated approach, turn-on sensing protein BSA under physiological conditions vitro monitoring within living cells. This all-round smart 1 has been designed functionalizing ordered...
Animals use pheromones as a conspecific chemical language to respond appropriately environmental changes. The soil nematode Caenorhabditis elegans secretes ascaroside throughout the lifecycle, which influences entry into dauer phase in early larvae, addition sexual attraction and aggregation. In adult hermaphrodites, pheromone sensory signals perceived by worms usually elicit repulsion an initial behavioral signature. However, molecular mechanisms underlying neuronal process from perception...
At its carboxylate-bridged diiron active site, the hydroxylase component of toluene/o-xylene monooxygenase activates dioxygen for subsequent arene hydroxylation. In an I100W variant this enzyme, we characterized formation and decay two species formed by addition to reduced, diiron(II) state rapid-freeze quench (RFQ) EPR, Mössbauer, ENDOR spectroscopy. The dependence rates mixed-valent transient on pH presence phenol, propylene, or acetylene was investigated double-mixing stopped-flow optical...
The effect of triethylenediamine (TEDA) (also named 1,4-diazabicyclo [2.2.2]octane, DABCO) on the adsorption ClCN a γ-Al2O3 absorbent has been investigated. Both Fourier transform infrared (FTIR) and theoretical studies indicate that no direct interaction between amine groups TEDA molecules takes place. Instead, we found competes with for active surface sites γ-Al2O3. In addition, behavior cyanogen chloride (ClCN) clean studied. sequence thermally activated processes diffusion, adsorption,...
The coadsorption of CO and triethylenediamine (TEDA) (also called 1,4-diazabicyclo[2.2.2]octane, DABCO) on a high-area γ-Al2O3 surface has been investigated with use transmission FTIR spectroscopy. It found that TEDA binds more strongly to both Lewis acid sites Brønsted Al−OH than does CO. Competition experiments indicate displaces less strong binding sites. Evidence for weak CO···TEDA interactions is in which small ν(CO) redshifts are produced. Comparison between different amines such as...
Physiological stresses, such as pathogen infection, are detected by "cellular Surveillance Activated Detoxification and Defenses" (cSADD) systems that trigger host defense responses.Aging is associated with physiological stress, including impaired mitochondrial function.Here, we investigated whether an endogenous cSADD pathway activated during aging in C. elegans.We provide evidence the transcription factor ZIP-2, a well-known immune response effector elegans, to age-associated...
<p>Supplementary Table 1. Association between OS/RFS and expression group of mPGES1 CD8 in stage III melanoma.</p>
<p>Supplementary Table 1. Association between OS/RFS and expression group of mPGES1 CD8 in stage III melanoma.</p>