A5100434399- Genetics, Aging, and Longevity in Model Organisms
- Circadian rhythm and melatonin
- Mitochondrial Function and Pathology
- Spaceflight effects on biology
- Birth, Development, and Health
- Adipose Tissue and Metabolism
- Autophagy in Disease and Therapy
- RNA modifications and cancer
- RNA Research and Splicing
- FOXO transcription factor regulation
- MicroRNA in disease regulation
- RNA and protein synthesis mechanisms
- Genomics, phytochemicals, and oxidative stress
- Coenzyme Q10 studies and effects
- Technology and Data Analysis
- Photoreceptor and optogenetics research
- Neurobiology and Insect Physiology Research
- Diet and metabolism studies
- Bone Tissue Engineering Materials
- CRISPR and Genetic Engineering
- Retinal Development and Disorders
- Air Quality and Health Impacts
- Receptor Mechanisms and Signaling
- Cancer-related molecular mechanisms research
- Alzheimer's disease research and treatments
Korea Advanced Institute of Science and Technology
2016-2025
Sungkyunkwan University
2024
Kangbuk Samsung Hospital
2024
Seoul National University
2015-2023
Korea Research Institute of Bioscience and Biotechnology
2013-2023
Korea University of Science and Technology
2022-2023
New Generation University College
2022
Korea Testing Laboratory
2022
Wonkwang University
2014-2021
Korea Aerospace Research Institute
2021
Summary Many conditions that shift cells from states of nutrient utilization and growth to cell maintenance extend lifespan. We have carried out a systematic lifespan analysis inhibit protein synthesis. find reducing the levels ribosomal proteins, ribosomal‐protein S6 kinase or translation‐initiation factors increases Caenorhabditis elegans . These perturbations, as well inhibition sensor target rapamycin (TOR), which is known increase lifespan, all thermal‐stress resistance. Thus inhibiting...
// Seong Kyu Han 1 , Dongyeop Lee Heetak Donghyo Kim Heehwa G. Son Jae-Seong Yang 4 Seung-Jae V. 1,2,3 and Sanguk Department of Life Sciences, Pohang University Science Technology, Pohang, Korea 2 IT Convergence Engineering, 3 School Interdisciplinary Bioscience Bioengineering, EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), Barcelona, Spain Correspondence to: Lee, email: Kim, Keywords : web-service, statistics, survival, maximum lifespan, healthspan Received...
Background Aging is a fundamental biological process. Characterization of genetic and environmental factors that influence lifespan crucial step toward understanding the mechanisms aging at organism level. To capture different effects on lifespan, appropriate statistical analyses are needed. Methodology/Principal Findings We developed an online application for survival analysis (OASIS) helps conduct various novel tasks involved in analyzing data user-friendly manner. OASIS provides standard...
Abstract Ageing is marked by physical decline. Caenorhabditis elegans a valuable model for identifying genetic regulatory mechanisms of ageing and longevity. Here we report simple method to assess C. ’ maximum ability based on the worms’ movement velocity. We show velocity declines with age, correlates well longevity, accurately reports and, if measured in mid-adulthood, predictive maximal lifespan. Contrary recent findings, observe that worm mutations daf-2(e1370) insulin/IGF-1 signalling...
Airborne fine particulate matter exhibits spatiotemporal variability at multiple scales, which presents challenges to estimating exposures for health effects assessment. Here we created a model predict ambient less than 2.5 μm in aerodynamic diameter (PM2.5) across the contiguous United States be applied modeling. We developed hybrid approach combining land use regression (LUR) selected with machine learning method, and Bayesian Maximum Entropy (BME) interpolation of LUR space-time...
When unfolded proteins accumulate in the endoplasmic reticulum (ER), protein response is activated. This ER stress restores homeostasis by coordinating processes that decrease translation, degrade misfolded proteins, and increase levels of ER-resident chaperones. Ribonuclease inositol-requiring protein–1 (IRE-1), an endoribonuclease mediates unconventional splicing, its target, XBP-1 transcription factor, are key mediators response. In this study, we show Caenorhabditis elegans insulin/IGF-1...
How are the rates of aging different tissues coordinated? In Caenorhabditis elegans, decreasing insulin/IGF-1 signaling extends lifespan by activating transcription factor DAF-16/FOXO. If DAF-16 levels experimentally increased in one tissue, such as intestine, activity other rises. Here we test hypothesis that this "FOXO-to-FOXO" occurs via feedback regulation ins-7 insulin gene expression. We find regulates expression and preventing blocks FOXO-to-FOXO from intestine to tissues. Our...
Significance Reactive oxygen species (ROS) have long been thought to cause aging and considered be toxic byproducts generated during mitochondrial respiration. Surprisingly, recent studies show that modestly increased ROS levels lengthen lifespan, at least in the roundworm Caenorhabditis elegans . It was unclear how of potentially are regulated promote longevity. Here we demonstrate activate two proteins, AMP-activated kinase (AMPK) hypoxia-inducible factor 1 (HIF-1), longevity by increasing...
Microgrid is becoming an essential part of the power grid regarding reliability, economy, and environment. Renewable energies are main sources energy in microgrids. Long-term solar generation forecasting important issue microgrid planning design from engineering point view. Solar mainly depends on radiation forecasting. can also be used for estimating degradation-rate-influenced potentials photovoltaic (PV) panel. In this paper, a comparative study different deep learning approaches carried...
Target of rapamycin (TOR) signaling is an evolutionarily well-conserved pathway that regulates various physiologic processes, including aging and metabolism. One the key downstream components TOR ribosomal protein S6 kinase (S6K) whose inhibition extends lifespan yeast, Caenorhabditis elegans, Drosophila, mice. Here, we demonstrate activation heat shock factor 1 (HSF-1), a crucial longevity transcription known to act insulin/IGF-1 (IIS) pathway, mediates prolonged conferred by mutations in...
Glucose-rich diets shorten the life spans of various organisms. However, metabolic processes involved in this phenomenon remain unknown. Here, we show that sterol regulatory element-binding protein (SREBP) and mediator-15 (MDT-15) prevent life-shortening effects a glucose-rich diet by regulating fat-converting Caenorhabditis elegans . Up-regulation SREBP/MDT-15 transcription factor complex was necessary sufficient for alleviating effect diet. Glucose feeding induced key enzymes convert...
The penetration of PVs into the power grid is increasing day by day, as they are more economical and environment-friendly. However, due to intrinsic intermittency in solar radiation other meteorological factors, generated from uncertain unstable. Therefore, accurate forecasting generation considered one fundamental challenges system. In this paper, a deep-learning model based on two-stage attention mechanism over LSTM proposed forecast day-ahead PV power. addition, Bayesian optimization...
A better understanding of the adverse health effects chronic exposure to fine particulate matter (PM2.5) requires accurate estimates PM2.5 variation at spatial scales. Remote sensing has emerged as an important means estimating exposures, but relatively few studies have compared remote-sensing those derived from monitor-based data.We evaluated and predictive capabilities remote geostatistical interpolation.We developed a space-time kriging model predict over continental United States...
Rhabdoid tumors (RT) are aggressive pediatric malignancies with poor prognosis. INI1/hSNF5 is a component of the chromatin remodeling SWI/SNF complex and tumor suppressor deleted in RT. Previous microarray studies indicated that reintroduction into RT cells leads to repression high degree mitotic genes including Aurora Kinase A (Aurora A, STK6). Here, we found INI1/SNF5 represses transcription cell-type-specific manner. INI1-mediated was observed normal but not non-RT cell lines. Chromatin...
In Caenorhabditis elegans and Drosophila melanogaster, removing the germline precursor cells increases lifespan. worms, possibly also in flies, this lifespan extension requires presence of somatic reproductive tissues. How gonad signals other tissues to increase is not known. The triggered by loss germ known require sterol hormone signaling, as reducing activity nuclear receptor DAF-12, or genes required for synthesis DAF-12 ligand dafachronic acid, prevents from extending addition FOXO...