A5058824688- Genetics, Aging, and Longevity in Model Organisms
- Birth, Development, and Health
- Mitochondrial Function and Pathology
- Circadian rhythm and melatonin
- FOXO transcription factor regulation
- Heat shock proteins research
- RNA Research and Splicing
- Alzheimer's disease research and treatments
- Neurobiology and Insect Physiology Research
- RNA regulation and disease
- Aging and Gerontology Research
- RNA modifications and cancer
- Spaceflight effects on biology
- PI3K/AKT/mTOR signaling in cancer
- Adipose Tissue and Metabolism
- Autophagy in Disease and Therapy
- RNA and protein synthesis mechanisms
Pohang University of Science and Technology
2012-2021
Target of rapamycin (TOR) signaling is an evolutionarily well-conserved pathway that regulates various physiologic processes, including aging and metabolism. One the key downstream components TOR ribosomal protein S6 kinase (S6K) whose inhibition extends lifespan yeast, Caenorhabditis elegans, Drosophila, mice. Here, we demonstrate activation heat shock factor 1 (HSF-1), a crucial longevity transcription known to act insulin/IGF-1 (IIS) pathway, mediates prolonged conferred by mutations in...
Glucose-rich diets shorten the life spans of various organisms. However, metabolic processes involved in this phenomenon remain unknown. Here, we show that sterol regulatory element-binding protein (SREBP) and mediator-15 (MDT-15) prevent life-shortening effects a glucose-rich diet by regulating fat-converting Caenorhabditis elegans . Up-regulation SREBP/MDT-15 transcription factor complex was necessary sufficient for alleviating effect diet. Glucose feeding induced key enzymes convert...
Long-lived organisms often feature more stringent protein and DNA quality control. However, whether RNA control mechanisms, such as nonsense-mediated mRNA decay (NMD), which degrades both abnormal well some normal transcripts, have a role in organismal aging remains unexplored. Here we show that NMD mediates longevity C. elegans strains with mutations daf-2/insulin/insulin-like growth factor 1 receptor. We find daf-2 mutants display enhanced activity reduced levels of potentially aberrant...
Many environmental factors that dynamically change in nature influence various aspects of animal physiology. Animals are equipped with sensory neuronal systems help them properly sense and respond to factors. Several studies have shown chemosensory thermosensory neurons affect the lifespan invertebrate model animals, including Caenorhabditis elegans Drosophila melanogaster. Although mechanisms by which these modulate incompletely understood, hormonal signaling pathways been implicated...
Significance RNA helicases are a large family of enzymes that regulate the generation and maintenance RNA. However, physiologic roles in animal aging remained unknown. Here we show an helicase, helicase 1 (HEL-1), extends lifespan roundworm Caenorhabditis elegans by up-regulating longevity transcription factor forkhead box O (FOXO). Our finding suggests can have rather specific longevity. A number studies variants FOXO linked to human In addition, mammalian HEL-1 homolog has been implicated...
The initiator tRNA (Met-tRNA i Met ) at the P site of small ribosomal subunit plays an important role in recognition mRNA start codon. In bacteria, carrier, IF2, facilitates positioning Met-tRNA on subunit. Eukarya contain eIF2 (unrelated to IF2), whose carrier activity is inhibited under stress conditions by phosphorylation its α-subunit stress-activated eIF2α kinases. stress-resistant eIF2A, was recently uncovered and shown load 40S associated with a conditions. Here, we report that eIF2A...
Heat shock factor 1 (HSF-1) and forkhead box O (FOXO) are key transcription factors that protect cells from various stresses. In Caenorhabditis elegans , HSF-1 FOXO together promote a long life span when insulin/IGF-1 signaling (IIS) is reduced. However, it remains poorly understood how cooperate to confer IIS-mediated longevity. Here, we show prefoldin 6 (PFD-6), component of the molecular chaperone prefoldin-like complex, relays longevity response under reduced IIS. We found PFD-6 was...
MON-2, which mediates Golgi-endosome trafficking, mitochondrial inhibition–induced longevity by enhancing autophagy.
Abstract PDZ domain‐containing proteins (PDZ proteins) act as scaffolds for protein–protein interactions and are crucial a variety of signal transduction processes. However, the role in organismal lifespan aging remains poorly understood. Here, we demonstrate that KIN‐4, microtubule‐associated serine‐threonine (MAST) protein kinase, is key longevity factor acting through binding PTEN phosphatase Caenorhabditis elegans . Through targeted genetic screen proteins, find kin‐4 required long daf‐2...