A5101808819- Advancements in Photolithography Techniques
- Ferroelectric and Piezoelectric Materials
- Semiconductor materials and devices
- Caching and Content Delivery
- Educational Systems and Policies
- RNA regulation and disease
- Acoustic Wave Resonator Technologies
- Electronic and Structural Properties of Oxides
- RNA modifications and cancer
- IoT and Edge/Fog Computing
- Electron and X-Ray Spectroscopy Techniques
- Advanced Surface Polishing Techniques
- RNA Research and Splicing
- Education and Learning Interventions
- Integrated Circuits and Semiconductor Failure Analysis
- Optical Coatings and Gratings
- Digital Marketing and Social Media
- Genomics, phytochemicals, and oxidative stress
- Opportunistic and Delay-Tolerant Networks
- Healthcare Education and Workforce Issues
- Metal and Thin Film Mechanics
- Technology Adoption and User Behaviour
- Peer-to-Peer Network Technologies
- Surface Roughness and Optical Measurements
- Health and Wellbeing Research
Korea Advanced Institute of Science and Technology
1996-2023
Korea Research Institute of Bioscience and Biotechnology
2009-2019
Pohang University of Science and Technology
2016-2018
Texas A&M Health Science Center
2015
Samsung (South Korea)
1997-2012
Electronics and Telecommunications Research Institute
2011
Beijing Museum of Natural History
2009
Hallym University
2008
The contrast mechanisms of domain imaging experiments assisted by atomic force microscope (AFM) have been investigated model on nonpiezoelectric (silicon oxide) and piezoelectric [Pb(Zr,Ti)O3] thin films. first step was to identify the electrostatic charge effects between tip, cantilever, sample surface. second explore tip–sample interaction. static deflection cantilever measured as a function dc bias voltage (Vdc) applied bottom electrode (n-type Si wafers) for noncontact contact modes. In...
The domain nucleation and growth during polarization switching in Pb(Zr,Ti)O3 (PZT) ferroelectric thin film capacitors with Pt top (TE) bottom electrodes (BE) were studied by means of atomic force microscopy (AFM). experimental configuration used this study differs from that conventionally (AFM tip/PZT/BE) where the AFM tip acts as a positionable TE. A small ac voltage was applied between step increasing dc bias voltage. induced piezoelectric vibration detected tip, its amplitude phase...
The dietary agent sulforaphane (SFN) has been reported to induce nuclear factor erythroid 2 (NF-E2)-related (Nrf2)-dependent pathways as well inhibiting histone deacetylase (HDAC) activity. current investigation sought examine the relationships between Nrf2 status and HDAC expression in preclinical translational studies. Wild type (WT) Nrf2-deficient (Nrf2−/+) mice were treated with colon carcinogen 1,2-dimethylhydrazine (DMH) followed by 400 ppm SFN diet (n = 35 mice/group). WT more...
The optical band gap is a basic property of materials. measured depends not only on the material but also its characteristics such as crystallinity and stoichiometry. chromium aluminum oxide films was calculated by three different methods. Firstly, we used conventional experimental-graphical method, which commonly used. However, this method applicable to an all-crystalline phase or all-amorphous phase. second one experimental-calculation composed both crystalline amorphous phases. We between...
The initiator tRNA (Met-tRNA i Met ) at the P site of small ribosomal subunit plays an important role in recognition mRNA start codon. In bacteria, carrier, IF2, facilitates positioning Met-tRNA on subunit. Eukarya contain eIF2 (unrelated to IF2), whose carrier activity is inhibited under stress conditions by phosphorylation its α-subunit stress-activated eIF2α kinases. stress-resistant eIF2A, was recently uncovered and shown load 40S associated with a conditions. Here, we report that eIF2A...
c-Src, a non-receptor protein tyrosine kinase, activates NF-κB and STAT3, which in turn triggers the transcription of anti-apoptosis- cell cycle-related genes. c-Src regulates proliferation, motility programmed death. And elevated level activated is related with solid tumor generation. Translation mRNA directed by an IRES element mediates persistent translation under stress conditions when most mRNAs inhibited phosphorylation alpha subunit eIF2 carrying initiator tRNA (tRNAi) to 40S...
Abstract Insulin/IGF-1 signaling (IIS) regulates various physiological aspects in numerous species. In Caenorhabditis elegans , mutations the daf-2 /insulin/IGF-1 receptor dramatically increase lifespan and immunity, but generally impair motility, growth, reproduction. Whether these pleiotropic effects can be dissociated at a specific step insulin/IGF-1 pathway remains unknown. Through performing mutagenesis screen, we identified missense mutation daf-18(yh1) that alters cysteine to tyrosine...
In order to identify Janus kinase/signal transducer and activator of transcription (JAK/STAT) signalling inhibitors, a cell-based high throughput screening was performed using plant extract library that identified Nb-(alpha-hydroxynaphthoyl)serotonin called MS-1020 as novel JAK3 inhibitor. potently inhibited persistently-active STAT3 in cell type-specific manner. Further examination showed selectively blocked constitutively-active consistently suppressed interleukin-2-induced JAK3/STAT5 but...
Abstract Accumulating evidence indicates that mitochondria play crucial roles in immunity. However, the role of mitochondrial Krebs cycle immunity remains largely unknown, particular at organism level. Here we show aconitase, ACO-2, a enzyme catalyzes conversion citrate to isocitrate, inhibits against pathogenic bacteria C. elegans . We find genetic inhibition aco-2 decreases level oxaloacetate. This increases unfolded protein response, subsequently upregulating transcription factor ATFS-1,...
A recent study revealed that poly(A)-binding protein (PABP) bound to poly(A) RNA exhibits a sharply bent configuration at the linker region between RNA-recognition motif 2 (RRM2) and RRM3, whereas free PABP highly flexible linear configuration. However, physiological role of structure mRNA-bound remains unknown. We investigated by constructing variant fails form poly(A)-dependent but maintains its activity. found PABP/poly(A) complex is required for PABP's efficient interaction with eIF4G...
To acquire the required resolution for 248- and 193-nm lithography, a study of attenuated phase-shifting mask (Att-PSM) technology is in progress. We performed simulation using matrix method to calculate relative transmittance amount phase shift light through PSM. However, we found that average film composition changed with deposition time. Accordingly, optical constants were be strong function thickness. Therefore rearranged relationship between parameters (e.g., time or gas flow rate...
ABSTRACT A large number of neuronal proteins must show correct spatiotemporal localization in order to carry out their critical functions. The mRNA transcript for the somatodendritic protein activity-regulated cytoskeleton-associated (Arc; also known as Arg3.1) contains two conserved introns 3′ untranslated region (UTR), and was proposed be a natural target nonsense-mediated decay (NMD). However, well-known NMD component Upf1 has differential roles transcriptional translational regulation...
Tumor cells overexpress amino acid transporters to meet the increased demand for acids. PQ loop repeat‐containing ( PQLC )2 is a cationic transporter that might be involved in cancer progression. Here, we show upregulation of 2 critical gastric GC ) development vitro and vivo. Both mRNA protein were overexpressed tissues, especially diffuse type. Overexpression promoted cell growth, anchorage independence, tumor formation nude mice. This was due activation MEK / ERK 1/2 PI 3K/ AKT signaling....
Content-centric networking based virtual private community (CCN/VPC) has been proposed for easy and secure content sharing between members in extended home domains. In this paper, we further introduce a personal cloud (vpCloud) service on CCN/VPC, propose more scalable intuitive membership management including enrollment process member list-based association. The association mechanism are optimally designed distributed consumer environment, whereof the provider support is not necessary. We...
Today, consumers possess a huge amount of personal contents due to increasing mobile devices and home appliances. This leads extension content sharing domain thus, privacy protection becomes more important. In this paper, we propose mechanism providing the fine-grained access control on in extended environment. Our scheme is based encryption supports notion groups flexible policy definition hierarchy using Access Control List (ACL). Though our proposed built hierarchical named following CCN...
Chromium aluminum oxide was chosen as a new candidate for use an attenuated phase-shifting mask (Att-PSM) material. The compositions of films were correlated with optical properties. With the measured and fitted data, we simulated transmittance phase shift using matrix method. Consequently, acquired optimum parameters Att-PSM's, such Al/Cr = 1.9-2.5 d 120 nm at 193-nm wavelength, 1.0-1.7 128 248-nm 0-0.1 170 365-nm wavelength. This simulation verified by measurement.
Modern persons should do many activities during limited time. In such situation, people feel time pressure because they think that is short. Time affects negatively several factors as satisfaction and intention to use through perceived cost. Ubiquity, an mobile service's characteristic in which users can desired information or services anywhere anytime, would let free from pressure. This study examines the relationship between moderating effect of ubiquity. We performed a survey for DMB...
본 연구는 아동의 ‘놀권리’에 대한 신문기사에 대해 형태소 및 감성 분석을 실시하여 언론의 아동 놀권리 인식을 분석하고 향후 정책 수립에 방향성을 논의하고자 수행되었다. 이를 위하여 놀권리에 선행연구를 고찰하고 빅카인즈 분석시스템을 통해 2015년 1월 1일부터 2018년 12월 31일까지의 일간지를 검색하였다. 그 결과 총 3842개의 자료를 수집하여 2회의 클리닝 과정을 거쳐 유아교육 전문가 3인에게 내용타당도를 검증 받아 1929개의 데이터를 추출하였다. 추출한 데이터는 R version 3.5.2를 활용하여 형태소를 분석하였고 Ucinet6을 네트워크 분석 실시하였다. 아동, 놀이, 놀권리, 놀이터, 시간, 등의 단어가 신문기사에서 자주 언급되는 것으로 분석되었으며, 감성분석결과 나타난 놀 권리에 감성은 긍정적인 감성이 더 높게 나타났다. 이러한 긍정단어들은 놀이정책, 놀이참여, 보장, 놀이 환경에 내용을 포함하고 있었다. 분석결과를 기반으로 ‘놀권리’ 보장과 연구의...