A5028958052- Fungal and yeast genetics research
- Cell death mechanisms and regulation
- Natural product bioactivities and synthesis
- Liver physiology and pathology
- NF-κB Signaling Pathways
- GaN-based semiconductor devices and materials
- Fish Biology and Ecology Studies
- Cancer-related Molecular Pathways
- 3D Printing in Biomedical Research
- Bioactive Compounds and Antitumor Agents
- Pancreatic function and diabetes
- Aquaculture Nutrition and Growth
- Genomics, phytochemicals, and oxidative stress
- Heat shock proteins research
- Fish biology, ecology, and behavior
- Urinary Bladder and Prostate Research
- Immune Response and Inflammation
- Ubiquitin and proteasome pathways
- Microtubule and mitosis dynamics
- Semiconductor Quantum Structures and Devices
- Probiotics and Fermented Foods
- Adipose Tissue and Metabolism
- Cancer, Hypoxia, and Metabolism
- Marine Bivalve and Aquaculture Studies
- Pluripotent Stem Cells Research
Kyung Hee University
2012-2025
Korea Research Institute of Bioscience and Biotechnology
2016-2025
Korea University of Science and Technology
2016-2025
Korea University
2019-2025
Bridge University
2023
Government of the Republic of Korea
2017-2021
Sangji University
2012-2019
Catholic University of Korea
2017-2018
Universidad de Oriente
1977-2017
Genome Research Foundation
2007-2015
Class III homeodomain-leucine zipper proteins regulate critical aspects of plant development, including lateral organ polarity, apical and meristem formation, vascular development. ATHB15, a member this transcription factor family, is exclusively expressed in tissues. Recently, microRNA (miRNA) binding sequence has been identified ATHB15 mRNA, suggesting that molecular mechanism governed by miRNA may direct development through ATHB15. Here, we show miR166-mediated mRNA cleavage principal for...
Abstract Posttranscriptional RNA metabolism plays versatile roles in the regulation of gene expression during eukaryotic growth and development. It is mediated by a group binding proteins with distinct conserved motifs. In this study, an Arabidopsis (Arabidopsis thaliana) gene, designated FLK, was identified shown to encode putative protein K homology A mutant which FLK inactivated T-DNA insertion exhibited severe late flowering phenotype both long short days. The reversed gibberellin...
Abstract Ulcerative colitis (UC), a type of inflammatory bowel disease (IBD), is chronic disorder the colon. Although UC generally treated with anti-inflammatory drugs or immunosuppressants, most these treatments often prove to be inadequate. Rosmarinic acid (RA) phenolic ester included in various medicinal herbs such as Salvia miltiorrhiz and Perilla frutescens . RA has many biological pharmacological activities, effect colonic tissue remains unclear. In this study, we investigated effects...
Single-crystalline GaN nanorods are formed on a sapphire substrate by hydride vapor phase epitaxy (HVPE). Their structural and optical properties investigated x-ray diffraction, scanning transmission electron microscopy, cathodoluminescence (CL) techniques. The high density of straight well-aligned with diameter 80–120 nm uniformly over the entire 2 in. substrate. diffraction patterns microscopic images indicate that pure single crystal preferentially oriented in c-axis direction. We...
Reversible protein phosphorylation, which is catalyzed by functionally coupled kinases and phosphatases, a major signaling mechanism in eukaryotic cellular functions. The red far-red light–absorbing phytochrome photoreceptors are light-regulated Ser/Thr-specific that regulate diverse photomorphogenic processes plants. Here, we demonstrate the phytochromes interact with catalytic subunit of phosphatase 2A designated FyPP. interactions were influenced phosphorylation status spectral...
Abstract We fabricated a spheroid-forming unit (SFU) for efficient and economic production of cell spheroids. optimized the protocol generating large homogenous liver cancer spheroids using Huh7 hepatocellular carcinoma (HCC) cells. The showed apoptotic proliferative signals in centre at surface, respectively. In particular, hypoxia-induced factor-1 alpha (HIF-1α) ERK signal activation were detected To diminish core necrosis increase oncogenic character, we co-cultured with 2% human...
The current treatment options for inflammatory bowel disease (IBD) are unsatisfactory. Therefore, novel and safer therapies needed. We previously reported that koreanaside A (KA) showed high radical scavenging activity suppressed vascular cell adhesion molecule 1 (VCAM-1) expression in smooth muscle cells. However, the molecular mechanisms involved its anti-inflammatory effect have not been reported. KA inhibited pro-inflammatory mediators such as inducible nitric oxide synthase (iNOS),...
The Hippo-YAP/TAZ signaling pathway plays a pivotal role in growth control during development and regeneration its dysregulation is widely implicated various cancers. To further understand the cellular molecular mechanisms underlying Hippo regulation, we have found that activities of core components, large tumor suppressor (LATS) kinases YAP/TAZ transcription factors, oscillate mitotic cell cycle. We identified anaphase-promoting complex/cyclosome (APC/C) Cdh1 E3 ubiquitin ligase complex,...
Directed differentiation of hPSCs and transition from 3D intestinal organoids into functional hIECs.
Obesity requires treatment to mitigate the potential development of further metabolic disorders, including diabetes, hyperlipidemia, tumor growth, and non-alcoholic fatty liver disease. We investigated anti-obesity effect a 30% ethanol extract Eisenia bicyclis (Kjellman) Setchell (EEB) on 3T3-L1 preadipocytes high-fat diet (HFD)-induced obese C57BL/6 mice. Adipogenesis transcription factors peroxisome proliferator-activated receptor (PPAR)γ, CCAAT/enhancer-binding protein-alpha (C/EBPα),...
Abstract Background Compound K [20- O -β-(D-glucopyranosyl)-20(S)-protopanaxadiol], a metabolite of the protopanaxadiol-type saponins Panax ginseng C.A. Meyer, has been reported to possess anti-tumor properties inhibit angiogenesis and induce tumor apoptosis. In present study, we investigated effect on apoptosis explored underlying mechanisms involved in HL-60 human leukemia cells. Methods We examined viabilities various cancer cell lines using MTT assays. DAPI assay, Annexin V PI double...
RhoB, a tumor suppressor, has emerged as an interesting cancer target, and extensive studies aimed at understanding its role in apoptosis have been performed. In our study, we investigated the involvement of RhoB-interacting molecules apoptosis. To identify proteins, performed yeast-two hybrid screening assays using RhoB bait isolated TNFAIP1, TNFalpha-induced protein containing BTB/POZ domain. The interaction between TNFAIP1 was demonstrated vivo through coimmunoprecipitation vitro binding...
The triterpene saponin ginsenoside Rh2 has been shown to have antiproliferative effects on various cancer cells. However, the effect of cell cycle and its underlying molecular mechanism in human leukemia cells are not fully understood. In this study, we found that inhibited proliferation concentration- time-dependently with an IC 50 ~38 µM. DNA flow cytometric analysis indicated blocked progression at G 1 phase HL-60 U937 cells, was be accompanied by downregulations cyclin-dependent kinase...
Alternative cell sources, such as three-dimensional organoids and induced pluripotent stem cell-derived cells, might provide a potentially effective approach for both drug development applications clinical transplantation. For example, the of sources liver cell-based therapy has been increasingly needed, transplantation is performed treatment patients with severe end-stage disease. Differentiated cells are expected to new tissue models revolutionary therapies. However, conventional...