A5060054387- Trace Elements in Health
- Cell death mechanisms and regulation
- Signaling Pathways in Disease
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Parkinson's Disease Mechanisms and Treatments
- Autophagy in Disease and Therapy
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related Molecular Pathways
- Neuroinflammation and Neurodegeneration Mechanisms
- Blood properties and coagulation
- DNA Repair Mechanisms
- Cancer Genomics and Diagnostics
- Cancer Mechanisms and Therapy
- Alzheimer's disease research and treatments
- Photosynthetic Processes and Mechanisms
- Cancer therapeutics and mechanisms
- Cytokine Signaling Pathways and Interactions
- Bioactive Compounds and Antitumor Agents
- Botulinum Toxin and Related Neurological Disorders
- Endoplasmic Reticulum Stress and Disease
- Neuroscience and Neuropharmacology Research
- Mitochondrial Function and Pathology
- Angiogenesis and VEGF in Cancer
- Melanoma and MAPK Pathways
Sungkyunkwan University
2025
Korea Research Institute of Bioscience and Biotechnology
2015-2024
YD Global Life Science (South Korea)
2023
Ewha Womans University Medical Center
2023
Rutgers, The State University of New Jersey
2014-2020
Rutgers Health
2020
Genome Research Foundation
2015
Johnson University
2013-2014
Ewha Womans University
2003-2011
Chungnam National University
2005
alpha-Synuclein is a key protein in Parkinson's disease (PD) because it accumulates as fibrillar aggregates pathologic hallmark features affected brain regions, most notably nigral dopaminergic neurons. Intraneuronal levels of this appear critical mediating its toxicity, multiplication gene locus leads to autosomal dominant PD, and transgenic animal models overexpressing human alpha-synuclein manifest impaired function or decreased survival Here, we show that microRNA-7 (miR-7), which...
Alzheimer's disease (AD) is a progressive neurodegenerative caused by genetic and non-genetic factors. Most AD cases may be triggered promoted environmental Clinical studies have reported that patients with show enhanced baseline levels of stress hormones in the blood, but their physiological significance respect to pathophysiology not clearly understood. Here we report mouse models exposed restraints for 2 h daily on 16 consecutive days increased beta-amyloid (Abeta) plaque deposition...
Abstract DNA damage-induced apoptosis suppressor (DDIAS) regulates cancer cell survival. Here we investigated the involvement of DDIAS in IL-6–mediated signaling to understand mechanism underlying role lung malignancy. We showed that promotes tyrosine phosphorylation signal transducer and activator transcription 3 (STAT3), which is constitutively activated malignant cancers. Interestingly, siRNA protein phosphatase (PTP) library screening revealed receptor mu (PTPRM) as a novel STAT3 PTP....
Abstract Cytochrome b5 reductase 3 (CYB5R3) is involved in various cellular metabolic processes, including fatty acid synthesis and drug metabolism. However, the role of CYB5R3 cancer development remains poorly understood. Here, we show that expression downregulated human lung cell lines tissues. Adenoviral overexpression suppresses growth vitro vivo. deficiency promotes tumorigenesis metastasis mouse models. Transcriptome analysis revealed apoptosis- endoplasmic reticulum (ER)...
Alzheimer's disease (AD) is the most common type of dementia. Its incidence rising rapidly as global population ages, leading to a significant social and economic burden. AD involves complex pathologies, including amyloid plaque accumulation, synaptic dysfunction, neuroinflammation. This study explores therapeutic potential N 5 -((perfluorophenyl)amino)glutamine (RA-PF), derivative γ-glutamyl-N'-(2-hydroxyphenyl)hydrazide (Ramalin), compound with antioxidant anti-inflammatory properties....
Abstract Cadmium is a heavy metal that accumulates in the body, and its accumulation brain damages both neurons glial cells. In current study, we explored mechanism underlying cadmium toxicity primary cortical astroglia cultures. Chronic treatment with 10 μM was sufficient to cause 90% cell death 18 hr. However, unlike observed neurons, cadmium‐induced astroglial not attenuated by antioxidants trolox (100 μM), caffeic acid (1 mM), vitamin C mM). contrast, extracellular 100 glutathione (GSH;...
Human Noxin (hNoxin, C11Orf82), a homolog of mouse noxin, is highly expressed in colorectal and lung cancer tissues. hNoxin contains DNA-binding C-domain RPA1, which mediates DNA metabolic processes, such as replication repair. Expression associated with S phase cells normal cells. was induced by ultraviolet (UV) irradiation. Knockdown caused growth inhibition The comet assay western blot analysis revealed that knockdown apoptosis through activation p38 mitogen-activated protein kinase...
α-Synuclein is a key pathogenic protein that aggregates in hallmark lesions Parkinson's disease and other α-synucleinopathies. Prior vitro studies demonstrated it substrate for cross-linking by transglutaminase 2 (TG2) into higher-order species. Here we investigated whether this increased aggregation occurs vivo TG2 exacerbates α-synuclein toxicity Mus musculus Saccharomyces cerevisiae. Compared with transgenic (SynTg) mice, animals double human (TG2Tg/SynTg) manifested greater...
MDH1 and MDH2 enzymes play an important role in the survival of lung cancer. In this study, a novel series dual MDH1/2 inhibitors for cancer was rationally designed synthesized, their SAR carefully investigated. Among tested compounds, compound 50 containing piperidine ring displayed improved growth inhibition A549 H460 cell lines compared with LW1497. Compound reduced total ATP content cells dose-dependent manner; it also significantly suppressed accumulation hypoxia-inducible factor...
Although gastric cancer is a common cause of mortality worldwide, its biological heterogeneity limits the available therapeutic options. Therefore, identifying novel targets for developing effective targeted therapy pressing need. Here, we investigate molecular function and regulatory mechanisms Vestigial-like 1 (VGLL1) in cancer. Microarray analysis 556 tissues revealed that VGLL1 was prognostic biomarker correlated with PI3KCA PI3KCB. regulates proliferation cells, as shown live cell...
Identifying biomarkers related to the diagnosis and treatment of gastric cancer (GC) has not made significant progress due heterogeneity tumors. Genes involved in histological classification genetic correlation studies are essential develop an appropriate for GC.In vitro vivo lentiviral shRNA library screening was performed. The expression Synaptotagmin (SYT11) tumor tissues patients with GC confirmed by performing Immunohistochemistry, between level patient's survival rate analyzed....
Abstract The central nervous system reserves high concentrations of free Zn 2+ in certain excitatory synaptic vesicles. In pathological conditions such as transient cerebral ischemia, traumatic brain injury, and kainic acid (KA)‐induced seizure, is released excess at synapses, which causes neuronal glial death. We report here that glutathione (GSH) can be used an effective means for protection neural cells from ‐induced cell death vitro vivo. Chronic treatment with 35 μM led to primary...
DNA damage-induced apoptosis suppressor (DDIAS) rescues lung cancer cells from in response to damage. DDIAS is transcriptionally activated by NFATc1 and EGF-mediated ERK5/MEF2B, leading cisplatin resistance cell invasion. Therefore, suggested as a therapeutic target for cancer. Here, we report that stability regulated E3 U-box ubiquitin ligase carboxyl terminus of HSP70-interacting protein (CHIP)-mediated proteasomal degradation. We first isolated CHIP an interacting partner yeast two-hybrid...
The IDF-11774, a novel clinical candidate for cancer therapy, targets HSP70 and inhibits mitochondrial respiration, resulting in the activation of AMPK reduction HIF-1α accumulation. To identify genes that have synthetic lethality to RNA interference screening was conducted, using pooled lentiviruses expressing short hairpin library. We identified ATP6V0C, encoding V0 subunit C lysosomal V-ATPase, knockdown which induced synergistic growth-inhibitory effect HCT116 cells presence IDF-11774....
Abstract Acquired resistance to inhibitors of anaplastic lymphoma kinase (ALK) is a major clinical challenge for ALK fusion-positive non-small-cell lung cancer (NSCLC). In the absence secondary mutations, epigenetic reprogramming one main mechanisms drug resistance, as it leads phenotype switching that occurs during epithelial-to-mesenchymal transition (EMT). Although drug-induced believed alter sensitivity cells anticancer treatments, there still much learn about overcoming resistance. this...
The tumor microenvironment comprising blood vessels, fibroblasts, immune cells, and the extracellular matrix surrounding cancer has recently been targeted for research in therapy. We aimed to investigate effect of macrophages on invasive ability gastric studied their potential mechanism. In transcriptome analysis, integrin αV was identified as a gene increased AGS cells cocultured with RAW264.7 cells. displayed adhesion greater invasiveness compared cultured alone. This invasion inhibited by...
α-Synuclein (α-Syn) is a key pathogenic protein in α-synucleinopathies including Parkinson disease (PD) and Dementia with Lewy Bodies. The aggregation of α-Syn believed to be deleterious critical step leading neuronal dysfunction death. One the factors that may contribute initial steps this crosslinking through transglutaminase 2 (TG2). We previously demonstrated overexpression TG2 exacerbates toxicity mice yeast by increasing higher-order species α-Syn. Herein, we investigated whether...
We previously reported that vestigial-like 1 (VGLL1), a cofactor of transcriptional enhanced associate domain 4 (TEAD4), is transcriptionally regulated by PI3K and β-catenin signaling involved in gastric cancer malignancy. However, the precise mechanism underlying regulation VGLL1 activation remains unknown. Therefore, we aimed to investigate molecular transforming growth factor-β (TGF-β)-mediated VGLL1-TEAD4 interaction cells. showed TGF-β phosphorylation this phosphorylated functioned as...