A5100638464- Cancer, Hypoxia, and Metabolism
- Mast cells and histamine
- Endoplasmic Reticulum Stress and Disease
- Alzheimer's disease research and treatments
- Heat shock proteins research
- Epigenetics and DNA Methylation
- Neuroinflammation and Neurodegeneration Mechanisms
- Redox biology and oxidative stress
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Protease and Inhibitor Mechanisms
- Asthma and respiratory diseases
- RNA Research and Splicing
- Mitochondrial Function and Pathology
- Enzyme Production and Characterization
- RNA modifications and cancer
- Immune cells in cancer
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- Immune Response and Inflammation
- Glutathione Transferases and Polymorphisms
- Angiogenesis and VEGF in Cancer
- Adipose Tissue and Metabolism
- Ubiquitin and proteasome pathways
- Cell Adhesion Molecules Research
- Autophagy in Disease and Therapy
Korea University
2025
University of California, Davis
2018-2024
Kyungpook National University
2015-2024
Chung-Ang University
2024
Konkuk University
2011-2022
Korea Research Institute of Bioscience and Biotechnology
2009-2022
Korea University of Science and Technology
2021-2022
National Institute of Environmental Research
2021-2022
Shriners Hospitals for Children - Northern California
2020-2022
Ewha Womans University
2022
Over-activation of microglia cells in the brain contributes to neurodegenerative processes promoted by production various neurotoxic factors including pro-inflammatory cytokines and nitric oxide. Recently, accumulating evidence has suggested that mitochondrial dynamics are an important constituent cellular quality control function. However, role microglial activation is still largely unknown. In this study, we determined whether associated with mediators lipopolysaccharide (LPS)-stimulated...
Nanoplastics, arising from the fragmentation of plastics into environmental pollutants and specialized commercial applications, such as cosmetics, have elicited concerns due to their potential toxicity. Evidence suggests that oral ingestion nanoplastics smaller than 100 nm may penetrate brain induce neurotoxicity. However, comprehensive research in this area has been hampered by technical challenges associated with detection synthesis nanoplastics. This study aimed bridge gap successfully...
Tracking the target: To identify a protein that binds directly to HIF-1α inhibitor LW6, series of new chemical probes were synthesized with clickable tag and/or photoactivatable moiety. LW6 was found be localized mitochondria (see picture) and MDH2 identified as target LW6. These results indicate inhibitory activity is consequence suppression. As service our authors readers, this journal provides supporting information supplied by authors. Such materials are peer reviewed may re-organized...
Mitochondrial dysfunction is implicated in age-related degenerative disorders such as Alzheimer's disease (AD). Maintenance of mitochondrial dynamics essential for regulating function. Aβ oligomers (AβOs), the typical cause AD, lead to and neuronal loss. AβOs have been shown induce fragmentation, their inhibition suppresses cell death. Oxidative stress one earliest hallmarks AD. Cyclin-dependent kinase 5 (Cdk5) may oxidative by disrupting antioxidant system, including Prx2. Cdk5 also...
Abstract The mechanisms by which oligodendroglia modulate CNS angiogenesis remain elusive. Previous in vitro data suggest that regulate endothelial cell proliferation and blood vessel formation through hypoxia inducible factor alpha (HIFα)-activated Wnt (but not VEGF) signaling. Using vivo genetic models, we show HIFα is necessary sufficient for independent of regions. At the molecular level, stabilization does perturb signaling but rather activates VEGF. functional genetically blocking...
The function of poly(ADP-ribosyl) polymerase 1 (PARP1) in myelination and remyelination the central nervous system (CNS) remains enigmatic. Here, we report that PARP1 is an intrinsic driver for oligodendroglial development myelination. Genetic depletion impairs differentiation oligodendrocyte progenitor cells (OPCs) into oligodendrocytes impedes CNS Mechanistically, PARP1-mediated PARylation activity not only necessary but also sufficient OPC differentiation. At molecular level, identify...
The neurovascular unit is a functional composed of neurons, glial cells, pericytes, and endothelial cells which sustain brain activity. While pericyte key component the unit, its role in cerebral blood flow regulation remains elusive. Recently, capillary stalling, means transient interruption microcirculation capillaries, has been shown to have an outsized impact on microcirculatory changes several neurological diseases. In this study, we investigated stalling possible causes, such as...
Abstract Eukaryotic N‐degron pathways are proteolytic systems with the ability to recognize specific N‐terminal residues of substrate proteins, which essential parts their degradation signals. Domains, referred as UBR boxes, several E3 ubiquitin ligases can basic N‐degrons. UBR6 is among seven mammalian family proteins containing box domain. However, recognition type‐1 N‐degrons by still not well understood. The crystal structure from human revealed zinc‐mediated dimerization, a structural...
In the present study, chemical compositions and skin whitening-related antioxidant anti-melanogenic effect of essential oils (EOs) extracted from Chrysanthemum borealeMakino (CBM) (CBMEOs) at vegetative, pre-flowering full-flowering are investigated contrasted among three stages. The yields components CBMEOs were different each stage. increased DPPH ABTs scavenging activities attenuated α-melanocyte stimulating hormone (α-MSH)-induced tyrosinase activity melanin synthesis in B16BL6 cells....
We used 2-DE and MALDI-TOF/TOF to identify proteins of vascular smooth muscle cells whose expression was or not altered by exposure 500 microM H2O2 for 30 min. detected more than 800 on silver-stained gels whole protein extracts from rat aortic strips. Of these proteins, 135 clearly unaffected 19 having levels were identified. Protein characterization revealed that the most prominent those with antioxidant, cytoskeletal structure, contraction. In addition, cofilin, an isoform actin...
The role of apurinic/apyrimidinic endonuclease-1/redox factor-1 (Ref-1) in vascular smooth muscle cells has yet to be clearly elucidated. Therefore, we attempted determine the roles Ref-1 migration induced by platelet-derived growth factor (PDGF)-BB and its signaling rat aortic (RASMCs). Cellular migration, superoxide (O 2 −· ) production, Rac-1 activity, neointima formation were determined transfected with adenoviruses encoding for (AdRef-1) small interference RNA Ref-1. Overexpression...
Mast cells are critical for various allergic disorders. express Src family kinases, which relay positive and negative regulatory signals by Ag. Lyn, example, initiates activating signaling events, but it also induces inhibitory signals. Fyn Hck reported to be regulators, little is known about the roles of other including Fgr, in mast cells. In this study, we define role Fgr. Endogenous Fgr associates with FcεRI promotes phosphorylation Syk, Syk substrates, include linkers activation T cells,...
Targeting a scaffold protein delivered by intracellular granules in mast cells may inhibit allergic responses.
The rupture of an atherosclerotic plaque is one the main causes coronary artery thrombotic occlusion, leading to myocardial infarction. However, exact mechanism and causal risk factors for remain unclear. To identify a potential molecule that can influence rupture, we investigated protein expression in serum from patients with acute infarction (AMI) stable angina (SA), using proteomic analysis. six proteins, including fibrinogen, fetuin-B, keratin 9, proapolipoprotein were altered AMI...