A5001991786- Mitochondrial Function and Pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer, Lipids, and Metabolism
- Inflammatory mediators and NSAID effects
- Neurological Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer Cells and Metastasis
- Ginseng Biological Effects and Applications
- Ubiquitin and proteasome pathways
- Osteoarthritis Treatment and Mechanisms
- 3D Printing in Biomedical Research
- Endoplasmic Reticulum Stress and Disease
- Histone Deacetylase Inhibitors Research
- Biochemical Acid Research Studies
- Signaling Pathways in Disease
- Biological and pharmacological studies of plants
- Fatty Acid Research and Health
- Pancreatic function and diabetes
- Protein Tyrosine Phosphatases
- Genetics and Neurodevelopmental Disorders
- Liver physiology and pathology
- Nuclear Receptors and Signaling
- Axon Guidance and Neuronal Signaling
- Protein Kinase Regulation and GTPase Signaling
Daegu-Gyeongbuk Medical Innovation Foundation
2020-2025
Korea Research Institute of Bioscience and Biotechnology
2016-2020
Kyungpook National University
2013-2018
Over-activation of microglia cells in the brain contributes to neurodegenerative processes promoted by production various neurotoxic factors including pro-inflammatory cytokines and nitric oxide. Recently, accumulating evidence has suggested that mitochondrial dynamics are an important constituent cellular quality control function. However, role microglial activation is still largely unknown. In this study, we determined whether associated with mediators lipopolysaccharide (LPS)-stimulated...
Mitochondrial dysfunction is implicated in age-related degenerative disorders such as Alzheimer's disease (AD). Maintenance of mitochondrial dynamics essential for regulating function. Aβ oligomers (AβOs), the typical cause AD, lead to and neuronal loss. AβOs have been shown induce fragmentation, their inhibition suppresses cell death. Oxidative stress one earliest hallmarks AD. Cyclin-dependent kinase 5 (Cdk5) may oxidative by disrupting antioxidant system, including Prx2. Cdk5 also...
Alternative cell sources, such as three-dimensional organoids and induced pluripotent stem cell-derived cells, might provide a potentially effective approach for both drug development applications clinical transplantation. For example, the of sources liver cell-based therapy has been increasingly needed, transplantation is performed treatment patients with severe end-stage disease. Differentiated cells are expected to new tissue models revolutionary therapies. However, conventional...
Oxidation of dopamine can cause various side effects, which ultimately leads to cell death and contributes Parkinson's disease (PD). To counteract oxidation, newly synthesized is quickly transported into vesicles via vesicular monoamine transporter 2 (VMAT2) for storage. VMAT2 expression reduced in patients with PD, studies have shown increased accumulation oxidation byproducts α-synuclein animals low expression. Conversely, that overexpress show better protection neurons. Based on these...
Glutamate-induced neurotoxicity is related to excessive oxidative stress accumulation and results in the increase of neuronal cell death. In addition, glutamate has been reported lead neurodegenerative diseases, including Parkinson's Alzheimer's diseases.It well known that Fraxinus rhynchophylla contains a significant level oleuropein (Ole), which exerts various pharmacological effects. However, mechanism neuroprotective effects Ole still poorly defined. this study, we aimed investigate...
Chrysophanic acid, or chrysophanol, is an anthraquinone found in <i>Rheum palmatum</i>, which was used the preparation of oriental medicine ancient China. The hippocampus plays a major role controlling activities short- and long-term memory. It one regions affected by excessive cell death Alzheimer's disease. Therefore, neuronal cell-death modulation important for maintaining function. We investigated chrysophanol's effects on glutamate-induced hippocampal death. Chrysophanol...
Chrysophanol, also called chrysophanic acid, is a natural anthraquinone compound found in Rheum palmatum. R. palmatum has been used oriental medicine ancient East Asia. Microglial cells represent not only the forefront immune defense central nervous system but most reactive sensors to various threats. However, activated microglia can exert neurotoxic effects via excessive production of cytotoxic molecules and proinflammatory cytokines. Therefore, modulation microglial cell activation...
XBP1 (X-box-binding protein 1) is activated in cancer and has a pivotal role tumorigenesis progression of human cancer. In particular, the transcriptional regulatory network well known to drive development, but little about whether stability regulated and, if so, what controls XBP1. present study we show that PIN1 prolyl isomerase interacts with active form (XBP1s) phosphorylation-dependent manner promotes XBP1s-induced cell proliferation transformation through regulation stability. By...
// Jae-Hye Lee 1, 3, * , Hyun-Soo Cho Jeong-Ju 1 Soo Young Jun 3 Jun-Ho Ahn Ju-Sik Min Ji-Yong Yoon Min-Hyuk Choi Su-Jin Jeon Jung Hwa Lim 2 Cho-Rok Dae-Soo Kim Hyun-Taek 4 Valentina M. Factor 5 Yun-Han 6 Snorri S. Thorgeirsson 7 Cheol-Hee Nam-Soon Genome Research Center, Korea Institute of Bioscience and Biotechnology, Daejeon 305-333, Republic Gene Therapy Unit, Department Functional Genomics, University Science Technology, Biology, Chungnam National University, 305-764, Laboratory...
// Ji-Yong Yoon 1, * , Jeong-Ju Lee Sujin Gu 2 Myoung Eun Jung Hyun-Soo Cho 4 Hwa Lim 3, Soo Young Jun Jun-Ho Ahn 1 Ju-Sik Min Min-Hyuk Choi Su-Jin Jeon Yong-Jae Areum Go 2, 5 Yun-Jeong Heo Cho-Rok Gildon Kwangho Moon-Kook and Nam-Soon Kim Genome Research Center, Korea Institute of Bioscience Biotechnology, Daejeon, 305-333, Republic Bio Drug Discovery Division, Chemical Technology, 34114, 3 Gene Therapy Unit, Department Functional Genomics, University Science 34113, Medicinal Chemistry...
Aim: Lennox-Gastaut syndrome (LGS) is a severe type of childhood-onset epilepsy with multiple types seizures, specific discharges on electroencephalography, and intellectual disability. However, LGS-related genes are largely unknown. To identify causative related to LGS, we collected analyzed data from three-generation Korean family in which one member had LGS two Methods: Genomic DNAs were extracted blood samples all participants used whole-exome sequencing (WES). Genetic variants detected...
The coiled-coil domain containing 50 (CCDC50) protein is a phosphotyrosine-dependent signalling stimulated by epidermal growth factor. It highly expressed in neuronal cells the central nervous system; however, roles of CCDC50 development are largely unknown. In this study, we showed that depletion CCDC50-V2 impeded process, including arbor formation, spine density development, and axonal outgrowth, primary neurons. Mechanistic studies revealed positively regulated nerve factor receptor,...
Abstract Malignancy cancer cells are reported to develop mechanisms resist anoikis (apoptotic cell death from deprivation of cell-cell/matrix interactions), thereby enhancing the survival and secondary tumor formation in distant organs, which is responsible for 90% cancer-related fatalities. A high serum level cholesterol (hypercholesterolemia) patients with colorectal cancers (CRCs) metastasis reported, but underlying relationship were never elucidated. Human CRC tissues revealed that...
Abstract Links between cholesterol and cancer are well-documented, but the mechanisms remain unclear. Squalene epoxidase (SQLE), a key enzyme in biosynthesis degraded by excess cholesterol, is suggested as proto-oncogene. Paradoxically, we found reduced SQLE aggressive colorectal (CRC); low being associated with shortened survival of CRC patients. This was confirmed spontaneous metastasis mouse model where SL-15 reduction, either high-cholesterol regimen or genetic knockdown, strikingly...
Links between cholesterol and cancer are well-documented, but the mechanisms remain unclear. Squalene epoxidase (SQLE), a key enzyme in biosynthesis degraded by excess cholesterol, is suggested as proto-oncogene. Paradoxically, we found reduced SQLE aggressive colorectal (CRC); low being associated with shortened survival of CRC patients. This was confirmed spontaneous metastasis mouse model where SL-15 reduction, either high-cholesterol regimen or genetic knockdown, strikingly promotes...