A5089196607- Liquid Crystal Research Advancements
- Advanced Optical Imaging Technologies
- RNA modifications and cancer
- Photonic Crystals and Applications
- Machine Learning in Bioinformatics
- Photonic and Optical Devices
- ATP Synthase and ATPases Research
- Semiconductor Lasers and Optical Devices
- Optical Coatings and Gratings
- Interactive and Immersive Displays
- Liver Disease Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Ubiquitin and proteasome pathways
- Metamaterials and Metasurfaces Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Optical Wireless Communication Technologies
- Orbital Angular Momentum in Optics
- Organic Light-Emitting Diodes Research
- RNA Interference and Gene Delivery
- Drug Transport and Resistance Mechanisms
- Advanced Materials and Mechanics
- Virtual Reality Applications and Impacts
- Phase-change materials and chalcogenides
- Photorefractive and Nonlinear Optics
- Nonlinear Optical Materials Studies
Keimyung University Dongsan Medical Center
2024
Keimyung University
2016-2024
National Taiwan University
2024
Meta (United States)
2021
Meta (Israel)
2021
University of Central Florida
2015-2019
Photonics (United States)
2014-2019
National Cancer Institute
2007-2016
Yonsei University
2013-2016
Center for Cancer Research
2009-2016
Abstract Hepatocarcinogenesis is a multistage process in which precursor lesions progress into early hepatocellular carcinomas (eHCC) by sequential accumulation of multiple genetic and epigenetic alterations. To decode the molecular events during stages liver carcinogenesis, we performed gene expression profiling on cirrhotic (regenerative) dysplastic nodules (DN), as well eHCC. Although considerable heterogeneity was observed at regenerative stages, overall, 460 differentially expressed...
Enhanced expression of the cancer stem cell (CSC) marker, CD133, is closely associated with a higher rate tumor formation and poor prognosis in hepatocellular carcinoma (HCC) patients. Despite its clinical significance, molecular mechanism underlying deregulation CD133 during progression remains to be clarified. Here, we report on novel by which interleukin-6/signal transducer activator transcription 3 (IL-6/STAT3) signaling up-regulates promotes HCC progression. STAT3 activated IL-6 rapidly...
Abstract In this review paper,we report recent progress on Pancharatnam-Berry (PB) phase optical elements, such as lens, grating, and deflector. PB lenses exhibit a fast switching time between two or more focal lengths with large diopter change aperture size, which is particularly attractive for addressing the accommodation mismatch in head-mounted display devices. On other hand, gratings deflectors offer large-angle beam deflection wide acceptance cone high efficiency, compared to...
Conventional head-mounted displays present different images to each eye, and thereby create three-dimensional (3D) sensation for viewers. This method can only control the stimulus vergence but not accommodation, which is located at apparent location of physical displays. The disrupted coupling between accommodation could cause considerable visual discomfort. To address this problem, in paper a novel multi-focal plane 3D display system proposed. A stack switchable liquid crystal...
We demonstrate a reflective liquid-crystal polarization volume grating with high efficiency for augmented reality displays. The coupling was measured to be 90% at 650 nm and 50° deflection angle. angular dependence of reflection band agrees well Bragg condition, the transmittance environment light is negligible scattering. bandwidth can tailored by controlling layer periodicity, allowing versatile applications design freedom not only realities but also other photonic devices.
Liquid-crystal-based Pancharatnam–Berry phase optical elements (PBOEs), also known as diffractive wave plates (DWPs), geometric optics (GPO), or holograms (GPHs), are functional planar structures with patterned orientation of anisotropy axis. Several scientifically interesting yet practically useful electro-optical effects, such focusing, beam splitting, waveguide coupling, and wavelength filtering, have been realized PBOEs. Because the high degree tunability, polarization selectivity,...
The angular resolution of current near-eye display devices is still far below human-eye acuity. How to achieve retina-level while keeping wide field-of-view (FOV) remains a great challenge. In this work, we demonstrate multi-resolution foveated with two panels and an optical combiner. first panel provides FOV but relatively low for the surrounding region, second one offers ultra-high central fovea by minifying system which enhances effective 5 ×. addition, switchable Pancharatnam-Berry phase...
Augmented reality (AR) displays are attracting significant attention and efforts. In this paper, we review the adopted device configurations of see-through displays, summarize current development status highlight future challenges in micro-displays. A brief introduction to optical gratings is presented help understand challenging design grating-based waveguide for AR displays. Finally, discuss most recent progress diffraction grating its implications.
The relative contribution of hepatocyte growth factor (HGF)/MET and epidermal (EGF)/EGF receptor (EGFR), two key signal transduction systems in the normal diseased liver, to fate decisions adult hepatic progenitor cells (HPCs) has not been resolved. Here, we developed a robust culture system that permitted expansion genetic manipulation capable multilineage differentiation vitro vivo examine individual roles HGF/MET EGF/EGFR HPC self-renewal binary cell decision. By employing...
We demonstrate a polarization-multiplexed multiplane display system for near-eye applications. A polarization-sensitive Pancharatnam-Berry phase lens is implemented to generate two focal depths simultaneously. spatial polarization modulator utilized direct the images designated planes. Based on this design, dual-focal-plane constructed without space- or time-multiplexing operations, suppress vergence-accommodation conflict successfully.
We report a rapid nano-imprinting technique to pattern the liquid crystal alignment of Pancharatnam-Berry phase microlens array. Through implementing single-side aligned cell, we demonstrate switchable array with fast response time and low operation voltage. Further investigation focusing property as well imaging capability ensure good quality Besides planar structures, this method is also promising for patterning on curvilinear surfaces.
Mito-TEMPO is a well-known mitochondria-specific superoxide scavenger. However, the effect of on porcine embryo development, to our knowledge, has not been studied yet. In present study, embryos were classified into two groups (G1 and G2) based cytoplasm lipid contents at zygote stage. The development blastocysts derived from G2 zygotes was reduced (G2:16.2 ± 7.9% vs G1: 26.5 5.9%; 1.6-fold, p < 0.05) compared those G1 zygotes. embryos, proportion TUNEL-positive cells also higher than that...
Motion picture response time (MPRT) affects the image blurs of thin-film transistor (TFT) liquid crystal displays and organic light emitting diode (OLED) displays. We derive an analytical equation to correlate MPRT with (LC)/OLED TFT frame rate. Good agreement between our physical model experimental results is obtained. Based on model, we find that if LC's 2 ms or less, then its nearly same as OLED, even OLED's assumed be 0. To achieve comparable OLEDs, developed ultra-low viscosity LC...
Polarization volume gratings are self-organized liquid crystal helical structures. They exhibit high diffraction efficiency and unique polarization selectivity. In this work, we investigate compare two different configurations of gratings: planar slanted We present the optical properties with emphasis on their polarizing nature. Further experimental results reveal existence configuration.
Abstract A simple approach is described to fabricate an electrically, thermally, and optically responsive polarization Bragg grating, using a dual‐frequency liquid crystal (LC) doped with photosensitive azobenzene chiral compound. Due the employed LC, reflection switchable by electric field. Based on trans ‐ cis isomerization of dopant, wavelength LC gratings can be tuned across visible UV exposure. Meanwhile, temperature responsivity also characterized. Good agreement between experiment...
We report a switchable lens in which twisted nematic (TN) liquid crystal cell is utilized to control the input polarization. Different polarization state leads different path length proposed optical system, turn results focal length. This type of has advantages fast response time, low operation voltage, and inherently lower chromatic aberration. Using pixelated TN panel, we can create depth information selected pixels thus add 2D image. By cascading three such device structures together,...
A tunable-focus liquid crystal microlens array is demonstrated and characterized. Using two-photon polymerization based direct-laser writing, a polymerized fabricated on one substrate. Such creates inhomogeneous electric field distribution homogeneous-like liquid-crystal alignment, simultaneously. The phase profile thus the focal length can be tuned dynamically by applied voltage. We also further investigate focusing property imaging capability of sample. adaptive as an example, we...
Polarization-dependent diffraction based on Pancharatnam-Berry phase optical elements (PBOEs) offers considerable benefits compared to conventional metasurfaces, such as negligible absorption, nearly 100% efficiency and an inexpensive fabrication process. Polarization holography is a simple way fabricate PBOEs, which entails the interference of beams with different polarizations generate spatial-varying polarization field. Thus, quality recorded PBOEs manifests high sensitivity length change...
Big data analysis has revealed the upregulation of cell division cycle associated 8 (CDCA8) in human hepatocellular carcinoma (HCC) and its poorer survival outcome. However, functions CDCA8 during HCC development remain unknown. Here, we demonstrate vitro that silencing inhibits growth long-term colony formation migration through accumulation G2/M phase population. Conversely, overexpression increases ability to undergo migration. RNA sequencing bioinformatic knockdown led same directional...
Considerable efforts have been devoted to augmented reality (AR) displays enable the immersive user experience in wearable glasses form factor. Transparent waveguide combiners offer a compact solution guide light from microdisplay front of eyes while maintaining see-through optical path view real world simultaneously. To deliver realistic virtual image with low power consumption, need high efficiency and good quality. One important limiting factor for diffractive is out-coupling problem...
Volume Bragg gratings (VBGs) have many applications, including filters, wavelength multiplexing devices, and see-through displays. As a kind of VBGs, polarization volume (PVGs) based on liquid crystal polymer the advantages nearly 100% efficiency, large deflection angle, high selectivity. However, previous reports regarding PVGs did not address tunable periodicity, flexibility. Here, we report stretchable, flexible, rollable PVG film with diffraction efficiency. The control by mechanical...
An electric field drives most dye-doped liquid crystal devices. Here, we demonstrate a new photo-responsive self-organized cholesteric device. Upon UV or blue light exposure, the helical twisting power of chiral azobenzene changes because trans-cis isomerization. As result, initially vertically aligned directors and dye molecules will change from transparent state to dark state. Such polarizer-free photo-activated dimmer can be used for wide range applications, such as diffractive photonic...