A5035521190- Optical Coherence Tomography Applications
- Coronary Interventions and Diagnostics
- Photoacoustic and Ultrasonic Imaging
- Advanced Fluorescence Microscopy Techniques
- Cardiac Imaging and Diagnostics
- Advanced Fiber Laser Technologies
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Disease and Adiposity
- Retinal Imaging and Analysis
- Peripheral Artery Disease Management
- Retinal Diseases and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Plasma Diagnostics and Applications
- Glaucoma and retinal disorders
- Advanced Fiber Optic Sensors
- Particle accelerators and beam dynamics
- Angiogenesis and VEGF in Cancer
- Photonic Crystal and Fiber Optics
- Acute Ischemic Stroke Management
- Renal and Vascular Pathologies
- Optical Network Technologies
- Semiconductor Lasers and Optical Devices
- Metal and Thin Film Mechanics
- Photonic and Optical Devices
- Retinal and Optic Conditions
Korea Advanced Institute of Science and Technology
2015-2024
Kyungpook National University Hospital
2022
Kootenay Association for Science & Technology
2018
Asan Medical Center
2014
Korea Basic Science Institute
2014
Korea University
2014
Hanyang University
2014
Harvard University
2004-2011
Massachusetts General Hospital
2005-2011
Duke Medical Center
2007
We demonstrate an ultrahigh-speed wavelength-swept semiconductor laser using a polygon-based wavelength scanning filter. With polygon rotational speed of 900? revolutionspersecond, continuous tuning rate 9200?nm?ms and repetition 115?kHz were achieved. The range the was 80?nm centered at 1325?nm, average polarized output power 23?mW.
Polarization sensitive optical coherence tomography (PS-OCT) provides a cross-sectional image of birefringence in biological samples that is complementary many applications to the standard reflectance-based image.Recent ex vivo studies have demonstrated mapping enables characterization collagen and smooth muscle concentration distribution vascular tissues.Instruments capable applying these measurements percutaneously may provide new insights into coronary atherosclerosis acute myocardial...
Polarization mode dispersion (PMD) has been recognized as a significant barrier to sensitive and reproducible birefringence measurements with fiber-based, polarization-sensitive optical coherence tomography systems.Here, we present signal processing strategy that reconstructs the local retardation robustly in presence of system PMD.The algorithm uses spectral binning approach limit detrimental impact PMD benefits from final averaging PMD-corrected vectors bins.The was validated numerical...
We report on an approach to exploit multiple light scattering by shaping the incident wavefront in optical coherence tomography (OCT). Most of reflected signal from biological tissue consists multiply scattered light, which is regarded as noise OCT. A digital mirror device (DMD) utilized shape such that maximal energy focused at a specific depth highly sample using coherence-gated reflectance feedback. The proof-of-concept experiment demonstrates this enhances depth-selective focusing...
We present a novel method for rapidly acquiring optical coherence tomography (OCT) images at multiple backscattering angles. By angularly compounding these images, high levels of speckle reduction were achieved. Signal-to-noise ratio (SNR) improvements 3.4 dB obtained from homogeneous tissue phantom, which was in good agreement with the predictions statistical model that incorporated parameters imaging system. In addition, fast acquisition rate system (10 kHz A-line repetition rate) allowed...
We demonstrate a high-speed wavelength-swept laser with tuning range of 104 nm (1228-1332 nm) and repetition rate 403 kHz. The design the utilizes high-finesse polygon-based wavelength-scanning filter short-length unidirectional ring resonator. Optical frequency domain imaging human skin in vivo is presented using this laser, system shows sensitivity higher than 98 dB single-side ranging depth 1.7 mm over 4 roll-off.
Lipid-rich inflamed coronary plaques are prone to rupture. The purpose of this study was assess lipid-rich in vivo using fully integrated high-speed optical coherence tomography (OCT)/near-infrared fluorescence (NIRF) molecular imaging with a Food and Drug Administration-approved indocyanine green (ICG).An intravascular OCT/NIRF catheter dual-modal system were constructed based on clinical OCT platform. For plaques, the NIRF-emitting ICG (2.25 mg/kg) or saline injected intravenously into...
Shortly after the first demonstration of optical coherence tomography for imaging microstructure human eye, work began on developing systems and catheters suitable intravascular in order to diagnose investigate atherosclerosis potentially monitor therapy. This review covers driving considerations clinical application its constraints, major engineering milestones that enabled current, high-performance commercial systems, key studies laid groundwork image interpretation, research traces (OCT)...
Inflammation plays essential role in development of plaque disruption and coronary stent-associated complications. This study aimed to examine whether intracoronary dual-modal optical coherence tomography (OCT)-near-infrared fluorescence (NIRF) structural–molecular imaging with indocyanine green (ICG) can estimate inflammation swine artery. After administration clinically approved NIRF-enhancing ICG (2.0 mg/kg) or saline, rapid (20 mm/s pullback speed) using a fully integrated OCT-NIRF...
Angpt-Tie2 is essential for choriocapillary maintenance, and Tie2 activation could be a therapeutic avenue fundamental treatment of NV-AMD.
Optical coherence tomography (OCT), an interferometric imaging technique, provides non-invasive, high-speed, high-sensitive volumetric biological in vivo. However, systemic features inherent the basic operating principle of OCT limit its performance such as spatial resolution and signal-to-noise ratio. Here, we propose a deep learning-based image enhancement framework that exploits raw interference fringes to achieve further from currently obtainable optimized images. The proposed for...
Full-field optical coherence microscopy (FFOCM) is an interferometric technique for obtaining wide-field microscopic images deep within scattering biological samples. FFOCM has primarily been implemented in the 0.8 mum wavelength range with silicon-based cameras, which may limit penetration when imaging human tissue. In this paper, we demonstrate at of 0.9 - 1.4 mum, where into tissue presumably greater owing to decreased scattering. Our system, comprising a broadband spatially incoherent...
Spectrally encoded confocal microscopy (SECM) is a technique that allows to be performed through the confines of narrow diameter optical fiber probe. We present novel scheme for performing SECM in which rapid wavelength swept source used. The system large field view images acquired at rates up 30 frames/second. Images resolution targets and tissue specimens ex vivo demonstrate high lateral (1.4 mum) axial (6 resolution. Imaging human skin was depths 350 mum, allowing cellular sub-cellular...
Abstract Macrophages mediate atheroma expansion and disruption, denote high-risk arterial plaques. Therefore, they are substantially gaining importance as a diagnostic imaging target for the detection of rupture-prone Here, we developed an injectable near-infrared fluorescence (NIRF) probe by chemically conjugating thiolated glycol chitosan with cholesteryl chloroformate, NIRF dye (cyanine 5.5 or 7), maleimide-polyethylene glycol-mannose mannose receptor binding ligands to specifically...
Rationale: Central nervous system has low vascular permeability by organizing tight junction (TJ) and limiting endothelial transcytosis. While TJ long been considered to be responsible for barrier in central system, suppressed transcytosis cells is now emerging as a complementary mechanism. Whether regulation independent of its dysregulation dominantly causes diseases associated with edema remain elusive. Dll4 signaling important various contexts, but role the maintenance remains unknown....
Abstract In optical coherence tomography (OCT), high-speed systems based at 1300 nm are among the most broadly used. Here, we present 9.4 MHz A-line rate OCT system nm. A wavelength-swept laser on stretched-pulse active mode locking (SPML) provides a continuous and linear-in-wavenumber sweep from 1240 to 1340 nm, using this light source sensitivity of 98 dB single-sided 6-dB roll-off depth 2.5 mm. We new capabilities SPML-OCT in three microscopy applications. First, demonstrate high quality...
Inflammation plays a pivotal role in the pathogenesis of acute coronary syndrome. Detecting plaques with high inflammatory activity and specifically treating those lesions can be crucial to prevent life-threatening cardiovascular events.
The neurovascular unit is a functional composed of neurons, glial cells, pericytes, and endothelial cells which sustain brain activity. While pericyte key component the unit, its role in cerebral blood flow regulation remains elusive. Recently, capillary stalling, means transient interruption microcirculation capillaries, has been shown to have an outsized impact on microcirculatory changes several neurological diseases. In this study, we investigated stalling possible causes, such as...
Proper regulation and patency of cerebral microcirculation are crucial for maintaining a healthy brain. Capillary stalling, i.e., the brief interruption has been observed in normal brain several diseases related to microcirculation. We hypothesized that endothelial glycocalyx, which is located on luminal side vascular endothelium involved cell-to-cell interaction peripheral organs, also capillary stalling. measured stalling glycocalyx (cEG) male mice using vivo optical coherence tomography...
Full-field optical coherence microscopy (FFOCM) utilizes gating to obtain high-resolution sections in thick tissues. FFOCM is an attractive technology for endoscopic at the cellular level since it does not require a high NA objective lens or beam scanning and therefore particularly amenable miniaturization. In this manuscript, we present novel scheme conducting that spectrally modulated, spatially incoherent illumination static Linnik interferometer. This approach advantageous allows be...
Polarization mode dispersion (PMD) severely degrades images of biological tissue measured with polarization-sensitive optical coherence tomography. It adds a bias to the local retardation value that can be spatially confined, resulting in regions seemingly high sample birefringence are purely artificial. Here, we demonstrate and analyze this effect, both experimentally numerical simulations, show artifacts avoided by limiting system PMD less than axial resolution. Even then, spatial...
Intravascular optical frequency-domain imaging (OFDI), a second-generation coherence tomography (OCT) technology, enables of the three-dimensional (3D) microstructure vessel wall following short and nonocclusive clear liquid flush. Although 3D vascular visualization provides greater appreciation intraluminal structures, longitudinal pitch that is several times bigger than resolution system has limited true high-resolution imaging, mainly due to slow scanning speed previous catheters. Here,...
The purpose of this study was to evaluate the performance optical coherence tomography angiography (OCTA) in visualizing laser-induced choroidal neovascularization (CNV) rodent retina.Choroidal induced via laser photocoagulation 2 male Brown Norway rats and C57BL/6 mice. For qualitative comparison, animals were imaged vivo with OCTA, indocyanine green (ICGA), fluorescein (FA), ex immunofluorescence confocal microscopy, 14 days post without anti-vascular endothelial growth factor (anti-VEGF)...
Innovations in laser engineering have yielded several novel configurations for high repetition rate, broad sweep range, and long coherence length wavelength swept lasers. Although these lasers enabled performance frequency-domain optical tomography, they are typically complicated costly many require access to proprietary materials or devices. Here, we demonstrate a simplified ring resonator configuration that is straightforward construct from readily available at low total cost. It was by an...