A5102908171- Advanced MRI Techniques and Applications
- Advanced NMR Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Advanced Memory and Neural Computing
- Neuroinflammation and Neurodegeneration Mechanisms
- Microwave Imaging and Scattering Analysis
- Semiconductor materials and devices
- Mesenchymal stem cell research
- Barrier Structure and Function Studies
- Semiconductor Quantum Structures and Devices
- Retinal Diseases and Treatments
- Immunotherapy and Immune Responses
- Insect and Arachnid Ecology and Behavior
- Radar Systems and Signal Processing
- Insect-Plant Interactions and Control
- Cell Adhesion Molecules Research
- Geophysical Methods and Applications
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Religious Studies and Spiritual Practices
- Plant and animal studies
- Radio Frequency Integrated Circuit Design
- Liver Disease Diagnosis and Treatment
- Salivary Gland Disorders and Functions
- Fungal Infections and Studies
- Glaucoma and retinal disorders
Korea Advanced Institute of Science and Technology
2018-2024
Washington University in St. Louis
2023-2024
Yonsei University
2021-2023
Severance Hospital
2021-2023
Korea Institute of Brain Science
2022
Seoul National University
2015-2020
Mando Corporation (South Korea)
2019
Sogang University
2016-2019
Gyeongsangnam-do Agricultural Research and Extension Services
2012-2018
Kookmin University
2007
Obtaining a histological fingerprint from the in-vivo brain has been long-standing target of magnetic resonance imaging (MRI). In particular, non-invasive iron and myelin, which are involved in normal functions histopathological hallmarks neurodegenerative diseases, practical utilities neuroscience medicine. Here, we propose biophysical model that describes individual contribution paramagnetic (e.g., iron) diamagnetic myelin) susceptibility sources to frequency shift transverse relaxation...
Rationale: Central nervous system has low vascular permeability by organizing tight junction (TJ) and limiting endothelial transcytosis. While TJ long been considered to be responsible for barrier in central system, suppressed transcytosis cells is now emerging as a complementary mechanism. Whether regulation independent of its dysregulation dominantly causes diseases associated with edema remain elusive. Dll4 signaling important various contexts, but role the maintenance remains unknown....
Transarterial chemoembolization (TACE) is an image-guided locoregional therapy used for the treatment of patients with primary or secondary liver cancer. However, conventional TACE formulations are rapidly dissociated due to instability emulsion, resulting in insufficient local drug concentrations target tumor. Methods: To overcome these limitations, a doxorubicin-loaded albumin nanoparticle-conjugated microbubble complex iodized oil emulsion (DOX-NPs-MB Lipiodol) has been developed as new...
This article presents Scaling-computing-in-memory (CIM), an energy-efficient embedded dynamic random access memory (eDRAM)-based in-memory-computing (IMC) accelerator with a dynamic-scaling readout for signal-to-quantization-noise ratio (SQNR) boosting and analog-to-digital converter (ADC) overhead reduction. It greatly saves the ADC cost by reducing required number of ADC-bit operations codesigning algorithm hardware. Scaling-CIM proposes three key features: 1) scaling (DSA) boosts SQNR...
Platelet adhesion and aggregation play a crucial role in arterial thrombosis ischemic stroke. Here, we identify platelet ERO1α (endoplasmic reticulum oxidoreductase 1α) as novel regulator of Ca
Multi-element transmit arrays with low peak 10 g specific absorption rate (SAR) and high SAR efficiency (defined as ( [Formula: see text]SAR text] are essential for ultra-high field (UHF) magnetic resonance imaging (MRI) applications. Recently, the adaptation of dipole antennas used MRI coil elements in multi-channel has provided community a technological solution capable producing uniform images at these strengths. However, human head-sized consisting have practical limitation to number...
A loss of salivary gland function often occurs after radiation therapy in head and neck tumors, though secretion saliva by the glands is essential for health maintenance oral environment. Transplantation acinar cells (ACs), part, may overcome side effects therapy. Here we directly differentiated mouse adipose-derived stromal (ADSCs) into ACs using a co-culture system. Multipotent ADSCs can be easily collected from vascular fractions adipose tissues. The isolated showed positive expression...
Nonalcoholic fatty liver disease (NAFLD) is a rapidly increasing chronic disorder worldwide accompanied by hepatic steatosis, inflammation, fibrosis, and severe failure. Unfortunately, an effective treatment strategy for NAFLD has not yet been established, which hampered the limited understanding of pathophysiological drivers NAFLD. To examine unknown cellular molecular mechanisms in pathogenesis NAFLD, there need direct vivo observation microenvironments over extended periods time. In this...
Abstract Cerebral microinfarct increases the risk of dementia. But how microscopic cerebrovascular disruption affects brain tissue in cellular‐level are mostly unknown. Herein, with a longitudinal intravital imaging, we serially visualized vivo dynamic changes astrocyte, pericyte and neuron as well microvascular integrity after induction cerebral microinfarction for 1 month mice. At day 2–3, it revealed localized edema acute astrocyte loss, neuronal death, impaired pericyte‐vessel coverage...
A loss of functional salivary glands often occurs after radiotherapy for head and neck tumour, causes many problems in oral health. Recently, the use salispheres, which consist gland stem cells (SGSCs), has been suggested as therapy these problems. However, an insufficient number can be obtained cultured cell transplantation. In present study, salispheres were propagated passaged by suspension culture to acquire a sufficient SGSCs therapy.The relationship between sphere formation degree...
Globally, ranavirus is often responsible for the mass mortality of a variety captive and wild amphibians. In Asia, several cases amphibians by are known, but one case in has been reported non-endemic larval bullfrog population Japan. order to verify factors involved Rana huanrenensis tadpoles (> 200 tadpoles) mountain stream South Korea, we investigated possible infections ranavirus, chytrid fungus, lethal bacteria conducting PCR assays pathogens with specific primers. We found that all R....
Chronic kidney disease (CKD) is one of the most common renal diseases manifested by gradual loss function with no symptoms in early stage. The underlying mechanism pathogenesis CKD various causes such as high blood pressure, diabetes, cholesterol, and infection not well understood. In vivo longitudinal repetitive cellular-level observation animal model can provide novel insights to diagnose treat visualizing dynamically changing pathophysiology its progression over time. this study, using...
Dental pulp is composed of nerves, blood vessels, and various types cells surrounded by a thick hard enamel-dentin matrix. Due to its importance in the maintenance tooth vitality, there have been intensive efforts analyze complex cellular-level organization dental teeth. Although conventional histologic analysis has provided microscopic images pulp, 3-dimensional (3D) visualization whole an intact remained technically challenging task. This mainly due inevitable disruption loss structural...
BACKGROUND: Ca 2+ release-activated channel regulator 2A (CRACR2A) has been linked to immunodeficiency attributable T-cell dysfunction in humans. We discovered that neutrophil CRACR2A promotes adhesive and migratory functions by facilitating mobilization β2 integrin activation. METHODS: Myeloid-specific cracr2a conditional knockout mice intravital microscopy were used investigate the physiologic role of recruitment vascular inflammation. Cracr2a-deficient neutrophils or dHL-60...
Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic diseases closely associated with metabolic system, including obesity and type 2 diabetes. The progression NAFLD advanced fibrosis an increased risk cirrhosis cancer as well various extra-hepatic diseases. Yet, underlying mechanism not fully understood partly due to absence effective high-resolution in vivo imaging methods appropriate animal models recapitulating pathology NAFLD. To improve our understanding about...
A compact but accurate HSPICE macromodel for single-bit resistive RAM (ReRAM) is proposed in this paper. This uses the minimum number of circuit elements to improve simulation speed. And, verified show very good agreement with measurements due voltage-controlled resistors used as SET and RESET describing well complicated current-voltage relationship ReRAM. An extended version also multi-bit ReRAM, where its resistance voltage can vary according pulse width applied
Purpose Myelin water imaging (MWI) reportedly corresponds closely to the myelin content in brain. An MWI technique based on multi‐echo gradient echo (mGRE) has recently been proposed as an alternative conventional spin‐echo‐based MWI. However, mGRE signal is vulnerable macroscopic field inhomogeneity, which makes unreliable. In present study, a z‐shim‐based single‐scan correction method overcome this limitation. Methods Z‐shim gradients slice‐selection direction were added sequence after...
Purpose: To establish a custom-built, high-speed 90 frame-per-second laser-scanning confocal microscope for real-time in vivo retinal imaging of individual flowing red blood cells (RBCs) vasculature live mouse model. Methods: Fluorescently labeled RBCs were injected into mice different ages (3 to 62 weeks old). Anti-CD31 antibody conjugated with Alexa Fluor 647 was visualize endothelial (ECs). Longitudinal and cross-sectional intravital ECs performed two strains (C57BL/6 Balb/c) by using the...
This paper presents Scaling-CIM, an energy-efficient eDRAM-IMC with the dynamic-scaling readout for SQNR boosting and ADC overhead reduction. Dynamic Scaling boosts of multi-bit operation even low-bit ADC. Adaptive analog bit-parallel accumulation reduces redundant operation. Also, layer-wise adaptive bit-truncation search further enhances efficiency on benchmarks. The accelerator is fabricated in 28nm CMOS technology occupies $2.03\mathrm{m}\mathrm{m}^{2}$ die area. It achieves 39.7 TOPS/W...