A5100744790- Thyroid Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Cancer, Hypoxia, and Metabolism
- Neurobiology of Language and Bilingualism
- Consumer Perception and Purchasing Behavior
- Cloud Computing and Resource Management
- BRCA gene mutations in cancer
- Metabolism, Diabetes, and Cancer
- Head and Neck Anomalies
- Thyroid Disorders and Treatments
- Education and Learning Interventions
- Global Cancer Incidence and Screening
- Radiomics and Machine Learning in Medical Imaging
- Second Language Acquisition and Learning
- Healthcare and Venom Research
- Parallel Computing and Optimization Techniques
- Cultural and Historical Studies
- Reading and Literacy Development
- Immune Response and Inflammation
- Healthcare Education and Workforce Issues
- Cancer, Lipids, and Metabolism
- Histone Deacetylase Inhibitors Research
- Pancreatic function and diabetes
- Cancer Diagnosis and Treatment
- Phonetics and Phonology Research
National Cancer Center
2016-2025
National Cancer Center
2018-2025
University of Central Florida
2018-2025
Florida College
2020-2025
Chung-Ang University
2015-2024
Catholic University of Korea
2005-2024
Seoul National University
1999-2024
Seoul National University Bundang Hospital
2008-2024
Kyung Hee University
2007-2023
Hallym University
2011-2023
Anaplastic thyroid cancer (ATC) and advanced differentiated cancers (DTCs) show fatal outcomes, unlike DTCs. Here, we demonstrate mutational landscape of 27 ATCs 86 DTCs by massively-parallel DNA sequencing, transcriptome 13 12 were profiled RNA sequencing. TERT, AKT1, PIK3CA, EIF1AX frequently co-mutated with driver genes (BRAFV600E RAS) in as well ATC, but tumor suppressors (e.g., TP53 CDKN2A) predominantly altered ATC. CDKN2A loss was significantly associated poor disease-specific...
Thyroid cancer has increased globally, with a prominent increase in small, papillary thyroid cancers (PTC). The Korean population high iodine intake, prevalence of BRAF V600E mutations, and family histories cancer. We examined the clinicopathological characteristics outcomes patients over four decades.The medical records 4500 patients, between 1962 2009 at single center, including 3147 PTC were reviewed.The mean age was 46.8±13.2 years; women accounted for 82.9% median follow-up duration 4.8...
We propose to furnish visual statistical methods with an inferential framework and protocol, modelled on confirmatory testing. In this framework, plots take the role of test statistics, human cognition tests. Statistical significance 'discoveries' is measured by having viewer compare plot real dataset collections simulated datasets. A simple but rigorous protocol that provides validity after 'lineup' popular from criminal legal procedures. Another 'Rorschach' inkblot test, well known...
We aimed to assess whether allelic variants of dopamine receptor, glutamate and serotonin transporter genes are associated with the appearance impulse control related behaviors (ICRB) in Parkinson's disease (PD) replacement therapy (DRT). surveyed ICRB consecutive Korean patients PD who were treated stable DRT using modified Minnesota Impulsive Disorders Interview over a period 4 months. In 404 completed interview 559 healthy normal controls, genotyping was performed for DRD3 p.S9G, DRD2...
Diabetes is an established risk factor for developing cancer. A limited body of evidence also suggests that cancer can increase the new cases diabetes, but inconclusive.To evaluate whether development associated with increasing subsequent diabetes.This cohort study included a nationally representative sample Korean general population observed up to 10 years (January 1, 2003, December 31, 2013). total 524 089 men and women 20 70 age without diabetes no history at baseline were...
Optimal glucose homeostasis requires exquisitely precise adaptation of the number insulin-secreting β-cells in islets Langerhans. Insulin itself positively regulates β-cell proliferation an autocrine manner through insulin receptor (IR) signaling pathway. It is now coming to light that cannabinoid 1 (CB1R) agonism/antagonism influences action insulin-sensitive tissues. However, cells on which CB1Rs are expressed and their function have not been firmly established. We undertook current study...
OBJECTIVE The aim of this study was to evaluate the association urinary cystatin C, a tubular damage marker, with progression type 2 diabetic nephropathy. RESERCH DESIGN AND METHODS baseline values serum and C were measured as primary parameters those nonalbumin protein (NAP) secondary parameters. In prospective observational study, total 237 patients followed up for 29 months (13–44 months). RESULTS Both C-to-creatinine ratio (CCR) NAP-to-creatinine (NAPCR) significantly different according...
Background: Active surveillance (AS) is an alternative to thyroidectomy for the management of low-risk papillary thyroid microcarcinoma (PTMC). However, prospective AS data collected from diverse populations are needed. Methods: This multicenter cohort study enrolled patients three referral hospitals in Korea. The participants were self-assigned into two groups, or immediate surgery. All underwent neck ultrasound every 6–12 months monitor disease progression. Progression under was evaluated...
Antagonizing the glucagon signaling pathway represents an attractive therapeutic approach for reducing excess hepatic glucose production in patients with type 2 diabetes. Despite extensive efforts, there is currently no human that directly inhibits glucagon/glucagon receptor pathway. We undertook a novel by generating high-affinity monoclonal antibodies (mAbs) to (GCGR) display potent antagonistic activity vitro and vivo. A single injection of lead antibody, mAb B, at 3 mg/kg, normalized...
Abstract Thyroid cancer is the most common in Korea. Several susceptibility loci of differentiated thyroid (DTC) were identified by previous genome-wide association studies (GWASs) Europeans only. Here we conducted a GWAS and replication study Koreans using total 1,085 DTC cases 8,884 controls, validated these results expression quantitative trait (eQTL) analysis clinical phenotypes. The robust associations observed NRG1 gene (rs6996585, P =1.08 × 10 −10 ) this SNP was also associated with...
Preoperative Serum Thyroglobulin as a Useful Predictive Marker to Differentiate Follicular Thyroid Cancer from Benign Nodules in Indeterminate cytology results increase the number of repetitive procedure and unnecessary surgery.This study was designed find useful simple predictive tools differentiate malignant thyroid nodules indeterminate nodules.We retrospectively enrolled 164 patients who had undergone surgery result National Center.We reviewed patients' age at diagnosis, sex,...
Background: In this ongoing multicenter prospective cohort study on active surveillance (AS) in low-risk papillary thyroid microcarcinoma (PTMC), we aimed to compare the quality of life (QoL) participants based their choice treatment, that is, AS or immediate surgery (OP). Methods: QoL 203 who chose and 192 underwent OP was evaluated using a thyroid-specific questionnaire at diagnosis during follow-up (median 8 months). Results: The mean ages groups were 47.3 ± 11.7 45.6 10.5 years (p =...
To investigate surgical, and clinical outcomes in patients with low-risk papillary thyroid microcarcinoma (PTMC) according to treatment options [immediate operation (IOP) vs delayed after active surveillance (AS) (DOP)].AS has been adopted as an alternative immediate surgery PTMC. Although some undergo during AS, there is little information on AS.A multicenter prospective cohort study including 1177 was conducted at 3 tertiary hospitals Korea from June 2016 January 2020. Patients PTMC were...
Young Joo Park, Eun Kyung Lee, Shin Song, Bon Seok Koo, Hyungju Kwon, Keunyoung Kim, Mijin Bo Hyun Won Gu Bae Woong Jung-Han Hee Na, Je Moon, Jung-Eun Sohyun Jun-Ook Ji-In Bang, Kyorim Back, Youngduk Seo, Dong Yeob Shin, Su-Jin Hwa Ahn, So Oh, Seung Hoon Woo, Ho-Ryun Won, Chang Hwan Ryu, Jee Yoon, Ka Yi, Min Kyoung Sang-Woo Sihoon Ah Joon-Hyop Ji Ye Jieun Cho Rok Dong-Jun Lim, Jae-Yol Yun Jeon, Kyong Yeun Jung, Ari Chong, Jae Chung, Chan Kwon Kwanhoon Jo, Yoon Cho, A Ram Hong, Chae Moon...