A5100780778- Thyroid Cancer Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Thyroid Disorders and Treatments
- Hepatitis B Virus Studies
- Head and Neck Anomalies
- Radiomics and Machine Learning in Medical Imaging
- Hepatitis C virus research
- Ovarian cancer diagnosis and treatment
- Cardiovascular Health and Disease Prevention
- Neuroendocrine Tumor Research Advances
- BRCA gene mutations in cancer
- Pituitary Gland Disorders and Treatments
- Blood Pressure and Hypertension Studies
- Pancreatic and Hepatic Oncology Research
- Bone health and osteoporosis research
- Cancer, Hypoxia, and Metabolism
- Biomarkers in Disease Mechanisms
- Chronic Kidney Disease and Diabetes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease and Transplantation
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Liver Diseases and Immunity
- Bone health and treatments
Pusan National University Hospital
2016-2025
Pusan National University
2014-2025
Samsung Medical Center
1999-2025
Sungkyunkwan University
2019-2025
VA Boston Healthcare System
2025
Biomedical Research Institute
2012-2024
National Cancer Center
2015-2024
Korea University
2018-2024
Configurations littéraires
2018-2022
Catholic University of Korea
2000-2022
Proton beam radiotherapy (PBT) has recently been applied to treat hepatocellular carcinoma (HCC); however, there is no randomized controlled trial-based evidence on its safety and efficacy. We compared the outcomes of PBT radiofrequency ablation (RFA) in patients with recurrent/residual HCC (rHCC) a phase III non-inferiority trial.Patients rHCC (size <3 cm, number ≤2) were randomly assigned receive or RFA according Child-Pugh score tumor stage. After randomization, if treatment was...
Purpose New nomenclature has incorporated metabolic traits and/or alcohol intake history to replace nonalcoholic fatty liver disease (NAFLD). Concerning the performance of different terminologies in Asian population, this study aimed investigate risk developing hepatocellular carcinoma (HCC) persons meeting criteria for subclasses disease. Materials and Methods Between 2002 2021, 28,749 participants from cancer registry linkage, who had no prior HCC, were prospectively included. Fatty was...
This study was done to evaluate clinical usefulness of cystatin C levels serum and urine in predicting renal impairment normoalbuminuric patients with type 2 diabetes the association between albuminuria serum/urine C. Type diabetic (n = 332) normoalbuminuria 210), microalbuminuria 83) macroalbuminuria 42) were enrolled. Creatinine, urinary albumin levels, estimated glomerular filtration rate (eGFR by MDRD [Modification Diet Renal Disease] CKD-EPI [Chronic Kidney Disease Epidemiology...
OBJECTIVE The aim of this study was to evaluate the association urinary cystatin C, a tubular damage marker, with progression type 2 diabetic nephropathy. RESERCH DESIGN AND METHODS baseline values serum and C were measured as primary parameters those nonalbumin protein (NAP) secondary parameters. In prospective observational study, total 237 patients followed up for 29 months (13–44 months). RESULTS Both C-to-creatinine ratio (CCR) NAP-to-creatinine (NAPCR) significantly different according...
Metabolic syndrome (MS) has 2 conflicting factors: obesity known to be protective against osteoporosis and an inflammation that activates bone resorption. The aim of this study was evaluate the difference mineral density(BMD) in women with or without MS according menopausal state. This is a cross-sectional 2,265 women(1,234-premenopausal, 931-postmenopausal) aged over 20 years who visited Health Promotion Center from January 2006 December 2009. We measured BMD at lumbar spine femoral neck....
Abstract Background This study aimed to evaluate the benefit of brachial-ankle pulse wave velocity (baPWV) as a noninvasive marker arterial stiffness for prediction all-cause and cause-specific mortality in patients with type 2 diabetes. Methods multicenter prospective observational analyzed 2308 diabetes between 2008 2018. The were categorized according quartiles baPWV. Cause was determined using death certificates patient clinical records. We estimated proportional rates from all causes,...
Background: Sorafenib and lenvatinib have been widely adopted to treat radioactive iodine (RAI)-refractory differentiated thyroid carcinoma (DTC). However, limited data exist regarding a direct comparison of these tyrosine kinase inhibitors (TKIs). We aimed evaluate the clinical efficacy safety two TKIs as first-line therapy in patients with distant metastatic or locally advanced, progressive, RAI-refractory DTC real-world practice. Methods: In this multicenter, retrospective cohort study,...
The aim of this study was to evaluate the influence coexistent Hashimoto's thyroiditis with papillary thyroid carcinoma on lymph node metastasis.The group defined by presence autoantibodies or pathologic confirmation. control did not have autoantibodies, disease, ultrasound findings thyroiditis.For group, only central metastasis had a lower frequency and mean number metastatic nodes than in after adjustment. With regard lateral involvement, there no significant difference between 2 groups....
Abstract Background A standard treatment for unresectable advanced-stage intrahepatic cholangiocarcinoma (IHCC) has not yet been established. Although neoadjuvant concurrent chemoradiotherapy (CCRT) and liver transplantation are associated with long-term survival in select patients, the outcomes of CCRT IHCC remain unclear. The aim our study was to evaluate patients IHCC. Methods We retrospectively reviewed records all advanced stage (stage IVa or IVb) who were pathologically diagnosed...
Background: Vitamin D has recently attracted attention because reduced levels are associated with the prevalence and aggressiveness of several cancers. This study aimed to evaluate relationship between preoperative serum 25 hydroxyvitamin (25(OH) vitamin D) clinicopathologic characteristics in female patients papillary thyroid cancer (PTC). Methods: A total 548 who underwent thyroidectomy for PTC June 2012 May 2013 were included. Blood samples obtained within two weeks prior surgery....
Little is known about population-based epidemiology and disease burden of autoimmune hepatitis (AIH). The aim this study was to investigate the prevalence, incidence, comorbidity direct medical cost AIH in South Korea.The data from nationwide, National Health Insurance Service claims database Rare Intractable Disease registration program. Age gender-specific prevalence rates were calculated, on comorbidity, diagnostic tests, prescribed drugs, costs retrieved for patients registered under...
Background Several inflammatory biomarkers, especially a high preoperative neutrophil-to-lymphocyte count ratio (NLR) and platelet-to-lymphocyte (PLR), are known to be indicator of poor prognosis in several cancers. However, very few studies have evaluated the significance NLR PLR papillary thyroid cancer (PTC). We association with clinicopathological characteristics patients PTC. Methods This study included 1,066 female who underwent total thyroidectomy for Patients were stratified into 4...
Sorafenib, a multi-kinase inhibitor, is approved for the treatment of patients with radioactive iodine (RAI)-refractory differentiated thyroid cancer (DTC). This study evaluated efficacy and safety sorafenib in real-world clinical practice compared results to those DECISION trial. The features associated better outcomes after were also evaluated.This multicenter, retrospective cohort 98 progressive RAI-refractory DTC who treated six tertiary hospitals Korea. primary objective was...
Background: Combination therapy with liothyronine (LT3) and levothyroxine (LT4) is used in patients persistent symptoms, despite being administered an adequate dose of LT4. LT3 may also be some thyroid cancer preparing for radioactive iodine therapy. However, there a controversy regarding the safety use, has been no definite evidence long-term Asian populations. The aim this study was to examine using Common Data Model (CDM). Methods: We conducted retrospective multicenter across four...
Primary liver cancer is one of the leading causes mortality worldwide. However, death have not been studied in detail patients with cancer.The and cause-specific risks primary cancer, diagnosed during 2000-2016, were investigated using nationwide population-based registry data South Korea (n=231,388). The cumulative incidence function Fine-Gray models used to estimate under competing risks. Risks non-cancer deaths relative general population compared by standardized ratios (SMRs).Among...
Young Joo Park, Eun Kyung Lee, Shin Song, Bon Seok Koo, Hyungju Kwon, Keunyoung Kim, Mijin Bo Hyun Won Gu Bae Woong Jung-Han Hee Na, Je Moon, Jung-Eun Sohyun Jun-Ook Ji-In Bang, Kyorim Back, Youngduk Seo, Dong Yeob Shin, Su-Jin Hwa Ahn, So Oh, Seung Hoon Woo, Ho-Ryun Won, Chang Hwan Ryu, Jee Yoon, Ka Yi, Min Kyoung Sang-Woo Sihoon Ah Joon-Hyop Ji Ye Jieun Cho Rok Dong-Jun Lim, Jae-Yol Yun Jeon, Kyong Yeun Jung, Ari Chong, Jae Chung, Chan Kwon Kwanhoon Jo, Yoon Cho, A Ram Hong, Chae Moon...
The aim of this study was to evaluate the association between urinary nonalbumin protein (NAP) and tubular markers in early diabetic nephropathy.Urinary NAP measured 118 patients with type 2 diabetes estimated glomerular filtration rates (eGFR) ≥60 mL/min/1.73 m². Urine levels [kidney injury molecule (KIM)-1, neutrophil gelatinase-assoicated lipocalin (NGAL) liver-type fatty acid-binding (L-FABP)] were by using an Enzyme-linked immunosorbent assay (ELISA). Patients divided into three groups...
The BRAF(V600E) mutation represents a novel indicator of the progression and aggressiveness papillary thyroid carcinoma (PTC). purpose this study was to determine clinical significance free circulating mutant in predicting advanced disease PTC.Seventy seven matched tumor plasma samples obtained from patients with both benign PTC were analyzed for using peptide nucleic acid (PNA) clamp real-time polymerase chain reaction (PCR).The absent DNA follicular adenomas or adenomatous goiter. In...