A5085790963- Cancer Immunotherapy and Biomarkers
- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- Sarcoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Renal cell carcinoma treatment
- Cancer-related gene regulation
- Inflammatory Biomarkers in Disease Prognosis
- Gastrointestinal Tumor Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lymphoma Diagnosis and Treatment
- Renal and related cancers
- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- Thyroid Cancer Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Prostate Cancer Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- Metastasis and carcinoma case studies
- Nutrition and Health in Aging
- Prostate Cancer Treatment and Research
- Urologic and reproductive health conditions
- Ovarian cancer diagnosis and treatment
- Radiomics and Machine Learning in Medical Imaging
Gangnam Severance Hospital
2019-2025
Yonsei University
2016-2025
Severance Hospital
2015-2025
Yonsei University Health System
2017-2024
Ewha Womans University
2019-2024
Chungnam National University
2023
Hanyang University Seoul Hospital
2021-2022
Hanyang University
2017-2021
Centre de Recherche en Cancérologie de Toulouse
2020
Inserm
2020
Objective: We investigated microsatellite instability (MSI) status and programed cell death ligand 1 (PD-L1) expression as predictors of prognosis responsiveness to chemotherapy for stage II/III gastric cancer. Background: The clinical implications MSI PD-L1 in cancer have not been well-elucidated. Methods: Tumor specimens information were collected from patients enrolled the CLASSIC trial—a randomized controlled study capecitabine plus oxaliplatin-based adjuvant chemotherapy. Five...
Tumour-infiltrating lymphocytes (TILs) have a strong prognostic significance, particularly in triple-negative breast cancer (TNBC). One important source of TILs is tertiary lymphoid structures (TLSs).To carry out histological analysis surgically resected TNBC to identify the location TLSs, relationship between TLSs and their significance TNBC.We retrospectively analysed 769 patients with TNBC.TILs were defined as percentage stroma invasive carcinoma infiltrated by lymphocytes. mainly present...
Markers of the epithelial-to-mesenchymal transition (EMT) in gastric tumor tissues are associated with poor patient outcomes. We performed a screen to identify pharmacologic compounds that kill cancer cells EMT-associated gene expression patterns and investigate their mechanisms.We identified 29 cell lines signature previously an EMT subtype, based on data from RNA sequence analyses, confirmed mesenchymal phenotypes 7 (Hs746T, SNU1750, MKN1, SK4, SNU484, SNU668, YCC11), invasive activity...
Abstract In this multi-center phase II trial, we evaluated the efficacy and safety of a quadruplet regimen (pembrolizumab, trastuzumab, doublet chemotherapy) as first-line therapy for unresectable or metastatic human epidermal growth factor receptor 2 (HER2)-positive advanced gastric cancer (AGC) (NCT02901301). The primary endpoints were recommended dose (RP2D) Ib objective response rate (ORR) II. secondary included progression-free survival (PFS), overall (OS), duration response, time to...
Abstract We aimed to determine the activity of anti-VEGF receptor tyrosine-kinase inhibitor, pazopanib, combined with anti-PD-L1 durvalumab, in metastatic and/or recurrent soft tissue sarcoma (STS). In this single-arm phase 2 trial (NCT03798106), treatment consisted pazopanib 800 mg orally once a day and durvalumab 1500 every 3 weeks. Primary outcome was overall response rate (ORR) secondary outcomes included progression-free survival (PFS), survival, disease control rate, immune-related...
Abstract Platinum-based chemotherapy is the cornerstone treatment for female high-grade serous ovarian carcinoma (HGSOC), but choosing an appropriate patients hinges on their responsiveness to it. Currently, no available biomarkers can promptly predict responses platinum-based treatment. Therefore, we developed Pathologic Risk Classifier HGSOC (PathoRiCH), a histopathologic image–based classifier. PathoRiCH was trained in-house cohort ( n = 394) and validated two independent external cohorts...
Background Primary thyroid lymphoma (PTL) is a very rare entity accounting for 5% of all malignancies and less than 2% lymphomas. PTLs are classified as non-Hodgkin’s B-cell lymphomas in the majority cases, although Hodgkin’s has also been identified. This study aimed to identify clinical, biochemical, pathological features primary Methods From January 2008 December 2020, data from patients diagnosed with PTL treated at Gangnam Severance Hospital, including lymphomas, were assessed. Results...
Critical reflection is an effective learning strategy that enhances clinical nurses' reflective practice and professionalism. Therefore, training programs for nurse educators should be implemented so critical can applied to nursing education. This study aimed investigate the effects of a competency program on improving thinking disposition, competency, teaching efficacy.A pilot was conducted using pre- post-test control-group design. Participants were recruited convenience sampling method....
Abstract Background In gastric cancer (GC) patients, metastatic progression through the lymphatic, hematogenous, peritoneal, and ovarian routes, is ultimate cause of death. However, genomic evolutionary characteristics GC have not been widely evaluated. Methods Whole-exome sequencing data were analyzed for 99 primary paired cancers from 15 patients who underwent gastrectomy metastasectomy. Results Hematogenous tumors associated with increased chromosomal instability de novo...
Young Joo Park, Eun Kyung Lee, Shin Song, Bon Seok Koo, Hyungju Kwon, Keunyoung Kim, Mijin Bo Hyun Won Gu Bae Woong Jung-Han Hee Na, Je Moon, Jung-Eun Sohyun Jun-Ook Ji-In Bang, Kyorim Back, Youngduk Seo, Dong Yeob Shin, Su-Jin Hwa Ahn, So Oh, Seung Hoon Woo, Ho-Ryun Won, Chang Hwan Ryu, Jee Yoon, Ka Yi, Min Kyoung Sang-Woo Sihoon Ah Joon-Hyop Ji Ye Jieun Cho Rok Dong-Jun Lim, Jae-Yol Yun Jeon, Kyong Yeun Jung, Ari Chong, Jae Chung, Chan Kwon Kwanhoon Jo, Yoon Cho, A Ram Hong, Chae Moon...
The purpose of this study was to analyze the utility Prostate Imaging Reporting and Data System version 2 (PI-RADSv2) in detection a clinically significant cancers patients with prostate biopsy Gleason score 6.A group 182 consecutively registered biopsy-proven cancer 6 underwent MRI radical prostatectomy. Clinically surgically defined as 7 or greater, tumor volume 0.5 cm3 category T3 greater. Clinical parameters (prostate-specific antigen level, greatest percentage core, positive cores)...
// Hyo Song Kim 1 , Su-Jin Shin 2 Seung-Hoon Beom Minkyu Jung Yoon Young Choi 3 Taeil Son Hyoung-Il Jae-Ho Cheong Woo Jin Hyung Sung Hoon Noh Hyunsoo Chung 4 Jun Chul Park Kwan Sang Kil Lee Yong Chan Woong Sub Koom 5 Joon Seok Lim 6 Hyun Cheol Sun Rha Hyunki Division of Medical Oncology, Department Internal Medicine, Yonsei University College Seoul, Republic Korea Pathology, Surgery, Gastroenterology, Radiation Radiology, Correspondence to: Kim, email: kimhyunki@yuhs.ac Rha, rha7655@yuhs.ac...
The Gleason grading system, currently the most powerful prognostic predictor of prostate cancer, is based solely on tumor's histological architecture and has high inter-observer variability. We propose an automated scoring system deep neural networks for diagnosis core needle biopsy samples. To verify its efficacy, was trained using 1133 cases samples validated 700 cases. Further, system-based results were compared with reference standards derived from three certified pathologists. In...
218 Background: We report the updated clinical data and molecular profiling results of a multi-institutional phase Ib/II trial triple combination (pembrolizumab, trastuzumab, chempotherapy) as first line therapy for HER2 positive advanced gastric gastroesophageal junction (AGC/GEJ) cancer. (PANTHERA trial; NCT02901301). Methods: Pembrolizumab 200mg IV D1, Trastuzumab 6mg/kg (after 8mg/kg load) Capecitabine 1000mg/m 2 bid D1-14, Cisplatin 80mg/m D1 every 3 weeks was selected recommended II...
Background and aims This study compared the prognostic significance of various nutritional inflammatory indicators such as neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio platelet-to-lymphocyte index, controlling status score. In addition, we aimed to establish a more accurate indicator. Methods We retrospectively evaluated 1112 patients with stage I–III colorectal cancer between January 2004 April 2014. The scores were classified low (0–1), intermediate (2–4), high (5–12)...
We aimed to investigate MYC expression and chromosomal aberration in mantle cell lymphoma (MCL), the clinical significance of these factors.Sixty-five patients with MCL, including 54 classic, nine blastoid two pleomorphic variants, were enrolled. Expression MYC, Ki67 p53 was assessed by immunohistochemistry. amplification or translocation examined fluorescence in-situ hybridization. higher blastoid/pleomorphic MCL variants (mean, 19.0%) than classic 1.9%; P < 0.001). also significantly...
Vascular endothelial growth factor pathway (VEGF)-tyrosine kinase inhibitors (TKIs) are used as the first-line treatment for patients with metastatic clear cell renal carcinoma (mCCRCC). Recently, programmed death-1 (PD-1) and death ligand-1 (PD-L1) blockade emerged promising therapy carcinoma. However, expression pattern prognostic implication of death-ligands (PD-Ls) in mCCRCC receiving VEGF-TKI remain unclear.PD-L1 PD-L2 tumor cells quantities PD-1+ tumor-infiltrating lymphocytes were...
3081 Background: Combining anti-PD-1 agent and trastuzumab has shown synergy in HER2 positive preclinical cancer models. We first report the result of a multi-institutional phase Ib/II trial triple combination (pembrolizumab, trastuzumab, chempotherapy) as line therapy for AGC. (PANTHERA trial; NCT02901301). Methods: Pembrolizumab 200mg IV D1, Trastuzumab 6mg/kg (after 8mg/kg load) Capecitabine 1000mg/m 2 bid D1-14, Cisplatin 80mg/m D1 every 3 weeks was selected recommended II dose. The...
Evidence on whether prior antibiotic (pATB) administration modulates outcomes of programmed cell death protein-1 (PD-1) inhibitors in advanced gastric cancer (AGC) is scarce. In this study, we find that pATB consistently associated with poor progression-free survival (PFS) and overall (OS) multiple cohorts consisting patients AGC treated PD-1 inhibitors. contrast, does not affect among irinotecan. Multivariable analysis the confirms independently predicts worse PFS OS. Administration pATBs...
ABSTRACT Accurate diagnosis is essential for effective cancer treatment, particularly in peritoneal surface malignancies, where failure to detect metastatic lesions can mislead the treatment plan. This study assessed diagnostic accuracy of staging laparoscopy using integration artificial intelligence (AI)‐guided photodynamic (PDD) with photosensitizer Phonozen, activated at 405 nm a rabbit model. To create carcinomatosis, VX2 cells were inoculated laparoscopically into peritoneum female...