A5046549908- AI in cancer detection
- Radiomics and Machine Learning in Medical Imaging
- Prostate Cancer Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Gastrointestinal disorders and treatments
- Urologic and reproductive health conditions
- Ovarian cancer diagnosis and treatment
- Chromatin Remodeling and Cancer
- Cancer-related Molecular Pathways
- Tumors and Oncological Cases
- Digestive system and related health
- Breast Lesions and Carcinomas
- Ultrasound Imaging and Elastography
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Helicobacter pylori-related gastroenterology studies
- Cell Image Analysis Techniques
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Aldose Reductase and Taurine
- Estrogen and related hormone effects
- HER2/EGFR in Cancer Research
- Cancer Mechanisms and Therapy
- Microbial metabolism and enzyme function
- Porphyrin Metabolism and Disorders
CHA Gangnam Medical Center
2014-2024
CHA University
2014-2024
Yonsei University
2011-2023
Severance Hospital
2014-2023
Abstract Platinum-based chemotherapy is the cornerstone treatment for female high-grade serous ovarian carcinoma (HGSOC), but choosing an appropriate patients hinges on their responsiveness to it. Currently, no available biomarkers can promptly predict responses platinum-based treatment. Therefore, we developed Pathologic Risk Classifier HGSOC (PathoRiCH), a histopathologic image–based classifier. PathoRiCH was trained in-house cohort ( n = 394) and validated two independent external cohorts...
To evaluate the expression levels of serine/glycine metabolism-related proteins (PHGDH, PSAT, PSPH, SHMT, and GLDC) in six different subtypes triple negative breast cancer (TNBC) patients gain insight into their implications. Formalin-fixed, paraffin-embedded tissues from 129 TNBC were assembled tissue microarrays. Immunohistochemical staining was performed for surrogate immunohistochemical markers (CK5/6, EGFR, claudin 3, 4, 7, E-cadherin, STAT1, interleukin-8 [IL-8], AR, GGT-1) identifying...
Background/Aims: Lysyl oxidase-like 2 (LOXL2), a collagenmodifying enzyme, has been implicated in cancer invasiveness and metastasis.Methods: We evaluated the expression of LOXL2 protein, addition to carbonic anhydrase IX (CAIX), keratin 19, epithelial cell adhesion molecule, interleukin 6, 105 resected hepatocellular carcinomas (HCCs) by immunohistochemistry. Results: positivity was found 14.3% (15/105) HCCs, it significantly associated with high serum α-fetoprotein levels, poor...
This study investigated the relationship between steroid hormone receptor signaling and cellular metabolism in tumorigenesis by examining expression of metabolic proteins with respect to androgen (AR) human epidermal growth factor receptor-2 (HER-2) status estrogen receptor-negative (ER−) breast cancer. ER− cancer cases (n = 334) were selected from a microarray analysis, including those that AR+ AR− 127 207, respectively) HER-2+ HER-2− 140 194, respectively). The involved glycolysis,...
유방의 과립세포 종양은 드물게 발생하는 양성 종양으로 말초 신경의 신경섬유초 세포에서 기원하는 것으로 알려져 있다. 종양의 임상적, 영상의학적 소견은 악성 종양 소견과 유사하여 종양임에도 불구하고 오인되기 쉽다. 저자들은 갑상선 기능 항진증으로 추적 관찰 중인 54세 여자의 우측 유방에서 중심 침생검과 면역조직화학 염색으로 진단된 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.
AT-rich interactive domain 1A (ARID1A) is frequently mutated in gastric cancer (GC), especially Epstein-Barr virus (EBV)-associated and microsatellite instability high GC. The loss of ARID1A expression has been reported as a poor prognostic marker However, the relationships between alteration EBV-associated GC, which are known to have favorable prognosis, hampered proper evaluation significance We aimed analyze true by correcting confounding variables.We evaluated large series (n=1,032)...
The present study aimed to determine the difference between clinical tumor stage (T stage) based on pre-operative ultrasound and histopathological T subsequent surgery in vacuum-assisted breast biopsy (VABB)-diagnosed cancer. Tumor sizes measured ultrasonography (USG) histologically were retrospectively calculated analyzed using paired t-tests 209 patients diagnosed with cancer VABB. classified into two groups, consisting of imaging reporting data system (BI-RADS) category 4a or below, who...
Caudal type homeobox (CDX)-1 and -2 are reportedly involved in the development progression of gastric cancer (GC). Although there several reports on prognostic significance CDX-2 expression GC, it remains controversial. In this study, we sought to validate value CDX-1 according histologic molecular subtypes GC.In total, 1,158 cases advanced GC were investigated using immunohistochemical staining tissue microarrays for expression, survival analysis was performed different histological...
<title>Abstract</title> The authors have requested that this preprint be removed from Research Square.