A5001245873- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Genetics and Neurodevelopmental Disorders
- Skin Protection and Aging
- Endoplasmic Reticulum Stress and Disease
- Ginger and Zingiberaceae research
- MicroRNA in disease regulation
- Natural product bioactivities and synthesis
- Ginseng Biological Effects and Applications
- NF-κB Signaling Pathways
- Molecular Biology Techniques and Applications
- Liver physiology and pathology
- Sesquiterpenes and Asteraceae Studies
- Retinoids in leukemia and cellular processes
- Endometriosis Research and Treatment
- FOXO transcription factor regulation
- Pancreatic and Hepatic Oncology Research
- Cancer-related Molecular Pathways
- Gallbladder and Bile Duct Disorders
- Autophagy in Disease and Therapy
- Pharmacological Effects of Natural Compounds
- Kruppel-like factors research
Korea Institute of Science and Technology
2012-2024
Yonsei University
2010-2022
Sookmyung Women's University
2016
Gangnam Severance Hospital
2011
Recently, proteomic technologies have demonstrated that several proteins are differently expressed in various body fluids of patients with endometriosis compared those without this condition. The aim study was to investigate secreted urine using techniques order identify potential markers for the clinical diagnosis endometriosis. Urine samples were collected from women undergoing laparoscopy different indications including pelvic masses, pain, suspicious endometriosis, infertility and...
The present study investigated the presence and mechanism of esculin-mediated renoprotection to assess its therapeutic potential. Esculin was orally administered at 20 mg/kg/day for 2 weeks streptozotocin-induced diabetic mice, effects were compared with those vehicle in normal mice. After oral administration esculin concentrations esculetin blood 159.5 ± 29.8 9.7 4.9 ng/mL 30 min, respectively. Food water intake significantly increased mice but attenuated receiving esculin. elevated glucose...
Background and Aims: Primary liver cancers (LCs), including HCC intrahepatic cholangiocarcinoma (iCCA), are derived from a common developmental lineage, conferring molecular spectrum between them. To elucidate the spectrum, we performed an integrative analysis of transcriptome profiles associated with patients’ radiopathologic features. Approach Results: We identified four LC subtypes (LC1–LC4) RNA‐sequencing profiles, revealing intermediate iCCA. LC1 is typical characterized by active bile...
Cannabidiol (CBD), a primary constituent in hemp and cannabis, exerts broad pharmacological effects against various diseases, including cancer. Additionally, cabozantinib, potent multi-kinase inhibitor, has been approved for treating patients with advanced hepatocellular carcinoma (HCC). Recently, there an increase research on combination therapy using cabozantinib to improve efficacy safety when patients. Here, we investigated the effect of treatment CBD HCC cells. enhanced sensitivity...
Hepatocellular carcinoma (HCC) undergoes a stepwise progression from liver cirrhosis to low-grade dysplastic nodule (LGDN), high-grade (HGDN), early HCC (eHCC), and progressed (pHCC). Here, we profiled multilayered genomic, epigenomic, transcriptomic aberrations in the hepatocarcinogenesis. Initial DNA methylation was observed eHCC (e.g., DKK3, SALL3, SOX1) while more extensive pHCC. In addition, eHCCs showed an initial loss of copy numbers tumor suppressor genes 4q 13q regions, thereby...
Obesity is an important and preventable risk factor for renal disease. The administration of antioxidant with a lipid-lowering effect therapeutic approach kidney disease in obese patients. present study was conducted to examine whether methanolic extract Dendrobium moniliforme (DM), one the most famous traditional medicines used many parts world, has vitro ameliorative on high-fat diet (HFD)-induced alterations such as dysfunction lipid accumulation vivo. 1,1-diphenyl-2-picrylhydrazyl...
// Ji Hae Nahm 1, * , Hyungjin Rhee 2, 3, 4, Haeryoung Kim 5 Jeong Eun Yoo 7 Jee San Lee 4 Youngsic Jeon Gi Hong Choi 6 and Young Nyun Park 1 Department of Pathology, Yonsei University College Medicine, Seoul, Korea 2 Radiology, 3 Brain 21 PLUS Project for Medical Science, Integrated Genomic Research Center Metabolic Regulation, Seoul National Hospital, Departments General Surgery, Severance Biomedical Science Institute, These are contributed equally to this work Correspondence to: Park,...
Background/Aims: Lysyl oxidase-like 2 (LOXL2), a collagenmodifying enzyme, has been implicated in cancer invasiveness and metastasis.Methods: We evaluated the expression of LOXL2 protein, addition to carbonic anhydrase IX (CAIX), keratin 19, epithelial cell adhesion molecule, interleukin 6, 105 resected hepatocellular carcinomas (HCCs) by immunohistochemistry. Results: positivity was found 14.3% (15/105) HCCs, it significantly associated with high serum α-fetoprotein levels, poor...
Abstract Peroxisome proliferator‐activated receptors (PPARs) are members of the nuclear hormone receptor superfamily ligand‐activated transcription factors and consist three isotypes: PPAR α , β / δ γ . PPARs expressed in various cell types skin, including keratinocytes, fibroblasts infiltrating immune cells. Thus, these highly studied dermato‐endocrine research, their ligands targets for treatment skin disorders, such as photoageing chronological ageing skin. Intensive studies have revealed...
Abstract The expression of estrogen receptor alpha (ERα, encoded by ESR1 ) has been shown to be associated with the prognostic outcomes patients in various cancers; however, its and mechanistic significance hepatocellular carcinoma (HCC) remain unclear. Here, we evaluated ERα association clinicopathological features 339 HCC patients. was expressed 9.4% (32/339) HCCs related better overall survival (OS; hazard ratio [HR] = 0.11, p 0.009, 95% C.I. 0.016–0.82) disease-free (DFS, HR 0.4, 0.013,...
BACKGROUNDNon-steroidal anti-inflammatory drug (NSAID)-activated gene-1 (NAG-1) is involved in cellular processes such as inflammation, apoptosis and tumorigenesis. However, little known about the expression function of NAG-1 endometrium. This study aimed to evaluate endometrium absence or presence endometriosis investigate effect celecoxib, a selective cyclooxygenase (COX)-2 inhibitor, on mRNA levels human endometrial stromal cells (HESCs).
Somatic mutations in the telomerase reverse transcriptase ( TERT ) promoter are related to activation and frequently occur at two hot spots located −124 −146 bp relative start codon various cancers. Here, we investigated occurrence implications of genetic alterations hepatitis B viral hepatocellular carcinoma (B HCC). mutations, especially −124C>T, clearly enhanced transcriptional activity HCC cell lines. In contrast, mRNA expression was lower patients with than those without. We...
Next-Generation Sequencing (NGS) is now widely used in biomedical research for various applications. Processing of NGS data requires multiple programs and customization the processing pipelines according to platforms. However, rapid progress applications methods urgently require prompt update pipelines. Recent clinical technology such as cell-free DNA, cancer panel, or exosomal RNA sequencing also appropriate Here, we developed SEQprocess, a highly extendable framework that can provide...
본 연구에서는 동해안에서 채집된 88종의 해조류에 대하여 미백제로서 응용 가능성을 알아보기 위해 멜라닌 생성에 미치는 영향을 in vitro 실험을 통해 알아보았다. Melan-a 세포에 해조류 추출물을 처리하여 양을 측정한 결과, 고리매, 미역쇠, 왜모자반, 감태, 톳추출물에서 생성이 감소되었으며, 특히 미역쇠추출물을 처리하였을 때 가장 유효하게 농도의존적으로 감소되었다. 생성 억제 효과가 tyrosinase 활성 저해와 관련 있는지를 확인한 약한 활성을 가지지만 직접 작용하여 저해하지는 않으면서, 세포 내의 저해하였다. 이는 내 활성저해가 직접적이 아닌 다른 기전에 의해 일어난다는 것을 의미하며, 그 기전 중의 하나인 <TEX>${\alpha}$</TEX>-glucosidase활성을 결과 저해하였으며, 높은 상관도를 보임을 확인하였다. 즉 미역쇠추출물은 N-linked glycoprotein인 tyrosinase의 glycosylation을 억제하여 이동이나 억제할 수...
Transforming growth factor-beta (TGF-β) has a dichotomous role, functioning as tumor suppressor and promoter. TGF-β signatures, explored in mouse hepatocytes, have been reported to predict the clinical outcomes of hepatocellular carcinoma (HCC) patients; HCCs exhibiting early signatures showed better prognosis than those with late signatures. The expression status remains unclear defined lesions human B-viral multistep hepatocarcinogenesis.The responsive were investigated analyzed for their...
This study is aimed at investigating the potential molecular features of allergic rhinitis (AR) and identifying gene signatures related transcription factors using transcriptome analysis in silico datasets. Transcriptome profiles were obtained three independent cohorts (GSE101720, GSE19190, GSE46171) comprising healthy controls (HC) patients with AR. The pooled dataset ( n = 82) was used to identify critical AR compared HC. Subsequently, key identified by a combined Gene ontology: bioprocess...
Abstract Ginsenosides, bioactive compounds derived from Panax ginseng, exhibit diverse pharmacological effects, including anti-cancer properties. Regorafenib, a potent multi-kinase inhibitor, is employed as second-line therapy for advanced hepatocellular carcinoma (HCC). However, the modest survival benefits observed in treated patients may be attributed to drug resistance. In this study, we screened panel of 40 ginsenosides their activity combination with regorafenib HCC cell lines and...