A5036471542- Skin Protection and Aging
- melanin and skin pigmentation
- GABA and Rice Research
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer Cells and Metastasis
- Food Quality and Safety Studies
- Biochemical Analysis and Sensing Techniques
- Diet and metabolism studies
- Polysaccharides and Plant Cell Walls
- Olfactory and Sensory Function Studies
- Phytochemicals and Antioxidant Activities
- Ginseng Biological Effects and Applications
- Garlic and Onion Studies
- Microbial Metabolism and Applications
- Natural Antidiabetic Agents Studies
- Phytochemical compounds biological activities
- Tea Polyphenols and Effects
- Peroxisome Proliferator-Activated Receptors
- Bee Products Chemical Analysis
- Autophagy in Disease and Therapy
- Phytochemistry and biological activity of medicinal plants
- Pomegranate: compositions and health benefits
- Drug-Induced Hepatotoxicity and Protection
- Diet, Metabolism, and Disease
Sejong University
2022-2024
Korea Food Research Institute
2020-2022
Cheil General Hospital and Women's Healthcare Center
2016-2018
Dankook University
2016-2018
Korea University
2012-2017
Molecular Oncology (United States)
2017
Lung cancer has a high incidence worldwide, and most lung cancer-associated deaths are attributable to metastasis. Although several medicinal properties of Panax ginseng Meyer have been reported, the effect ginsenosides Rk1 Rg5 on epithelial-mesenchymal transition (EMT) stimulated by transforming growth factor beta 1 (TGF- β1) self-renewal in A549 cells is relatively unknown.We treated TGF-β1 or alternatively cells. We used western blot analysis, real-time polymerase chain reaction (qPCR),...
Lipid accumulation using Oil Red O dye was measured in 3T3-L1 murine adipocytes to examine the anti-obesity effect of four types germinated rice, including brown rice (GBR), waxy (GWBR), black (GB-R), and (GWB-R). GBR methanol extract exhibited highest suppression lipid cell line also on high fat induced-obese mice. The mice were divided into three groups administered: ND, a normal diet; HFD control, GBR, diet plus 0.15% for 7 weeks. administration significantly decreased body weight gain...
Obesity is viewed as a serious public health problem. This study aimed to investigate the antiobesity effects of fermented garlic extract by lactic acid bacteria (LAFGE) on obesity. Male C57BL/6J mice were fed with high-fat diet (HFD) induce The HFD-induced obese orally administrated 250 or 500 mg/kg LAFGE for 8 weeks. Feeding HFD-fed reduced body weight 14% and 18%, respectively, compared HFD. administration had lower epididymal, retroperitoneal, mesenteric adipose tissue mass 36%, 44%,...
Abstract BACKGROUND: Kefir, a traditional fermented milk composed of microbial symbionts, is reported to have various health benefits such as anti‐tumour, anti‐inflammatory, anti‐neoplastic and pro‐digestive effects. In this study, elucidate the effects kefir on adipocyte differentiation lipid accumulation, three fractions were prepared from culture broth. The inhibitory liquid broth fraction (Fr‐1), soluble (Fr‐2) insoluble (Fr‐3), by sonication solid broth, in 3T3‐L1 preadipocytes...
Excessive body fat accumulation can result in obesity, which is a serious health concern. Kefir, probiotic, has recently shown possible benefits fighting obesity. This study investigated the inhibitory effects of 0.1 and 0.2% kefir powder on adipose liver tissues high-fat diet (HFD)-induced obese mice. Kefir reduced weight epididymal pad decreased adipocyte diameters HFD-induced was supported by expression genes related to adipogenesis lipogenesis as well proinflammatory marker levels fat....
We sought to investigate the effect of extracts from Rosa gallica petals (RPE) on skin whitening and anti-wrinkle activity. Tyrosinase activity was attenuated by RPE treatment, concomitant with reduction melanin accumulation in human B16F10 melanoma. Treatment facial volunteers a clinical trial an RPE-containing formulation enhanced brightness (L* value) significantly. The underlying mechanism responsible determined be associated mitogen-activated protein kinase (MAPK) activation. In...
Abstract Epithelial‐to‐mesenchymal transition (EMT), important cellular process in metastasis of primary tumors, is characterized by loss their cell polarity, disruption cell‐cell adhesion, and gain certain properties mesenchymal phenotype that enable migration invasion. Delphinidin a member anthocyanidin belong to flavonoid groups, known as having pharmacological physiological effects including anti‐tumorigenic, antioxidative, anti‐inflammatory, antiangiogenic effects. However, the...
Red ginseng has been reported to elicit various therapeutic effects relevant cancer, diabetes, neurodegenerative diseases, and inflammatory diseases. However, the effect of red on exercise endurance skeletal muscle function remains unclear. Herein, we sought investigate whether could affect examined its molecular mechanism. Mice were fed with extract (RG) undertook swimming exercises determine time exhaustion. Animals RG had significantly longer endurance. treatment was also observed enhance...
Rosa gallica is a widely used species for medicinal and culinary purposes. has been reported to display antioxidant, anti-inflammatory, antibacterial activities. However, the effect of against skin aging in vivo unknown its active components have not fully understood. Oral administration prevented UVB-mediated wrinkle formation loss collagen/keratin fibers dorsal mice. Examination biomarkers at molecular level showed that downregulates UVB-induced COX-2 MMP-1 expression skin. Through direct...
Abstract Epithelial-mesenchymal transition (EMT) is a major cellular process in which epithelial cells lose cell polarity and cell-cell adhesion become motility invasiveness by transforming into mesenchymal cells. Catechol one of the natural compounds present fruits vegetables has various pharmacological physiological activities including anti-carcinogenic effects. However, effects catechol on EMT not been reported. Epidermal growth factor (EGF) factors known to play role inducing EMT. The...
Abstract Background There is active research on developing materials for improving skin function. Eggshell membrane (ESM) one such raw material that consumed as a functional food to support health. However, studies the mechanism of improvement function ingestion ESM are still lacking. Objectives To explore this action, we conducted an ultraviolet (UV) irradiation study SKH-1 hairless mouse model. Feeding was found improve moisture and reduce wrinkles during 12 weeks UVB irradiation. Results...
Beer brewing produces >39 million tons of brewer's spent grain (BSG) per year worldwide. Although BSG is rich in protein, fiber, and phytochemicals, it mainly used as livestock feed, some discarded. In this study, we attempted to assess the antimelanogenesis effects identify functional components. To end, investigated antioxidant antimelanin synthesis a extract (BSGE). The results showed that BSGE has high DPPH radical-scavenging activity inhibited α-MSH-induced melanin B16F10 cells cultured...
Excessive exposure to ultraviolet (UV) radiation from sunlight accelerates skin aging, leading various clinical manifestations such as wrinkles, dryness, and loss of elasticity. This study investigated the protective effects porcine placenta peptide (PPP) against UVB-induced photoaging. Female hairless SKH-1 mice were orally administered PPP for 12 weeks, followed by UVB irradiation. significantly reduced wrinkle formation, improved moisture levels, prevented collagen degradation....
This study aimed to examine the anti-diabetic effect of germinated waxy black rice (GWBR) using streptozotocin (STZ)-induced diabetic rats. In rats, GWBR supplementation for 8 weeks reduced plasma blood glucose concentrations, improved clearance and prevented diabetes-induced weight loss. Rats with STZ-induced diabetes who received exhibited decreased expression sodium-dependent transporter 1 (SGLT1) (GLUT) 2 genes proteins in small intestine via decreases hepatocyte nuclear factor (HNF)-1α,...
Ginsenoside Rf (G-Rf) is a saponin of the protopanaxatriol family and bioactive component Korean ginseng. Several ginsenosides are known to have positive effect on exercise endurance, but there not yet report that G-Rf. Forced swimming tests were performed G-Rf-treated mice evaluate G-Rf endurance. Subsequently, expression markers related myoblast differentiation mitochondrial biogenesis in murine skeletal C2C12 myotubes tibialis anterior muscle tissue was determined using Western blotting,...
Scope Rose petal extract (RPE) shows a significant antioxidant effect through its anthocyanin content. However, the mechanism underlying anti‐aging effects of orally administered RPE remains unclear. This study aims to describe and action in ultraviolet (UV)B‐induced skin aging. Methods results evaluates protein expression collagen type I alpha 1 (COL1A1) matrix metalloproteinase (MMP‐1) mRNA hyaluronic synthase 2 ( HAS2 ) human dermal fibroblasts. In addition, hyaluronidase collagenase...