A5102801484- Cervical Cancer and HPV Research
- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- Genital Health and Disease
- Microtubule and mitosis dynamics
- PI3K/AKT/mTOR signaling in cancer
- Reproductive tract infections research
- Metastasis and carcinoma case studies
- Cancer Cells and Metastasis
- Telomeres, Telomerase, and Senescence
- Pancreatic function and diabetes
- Molecular Biology Techniques and Applications
- Epigenetics and DNA Methylation
- Intraperitoneal and Appendiceal Malignancies
- Cancer, Hypoxia, and Metabolism
- Microbial Natural Products and Biosynthesis
- Actinomycetales infections and treatment
- Eosinophilic Disorders and Syndromes
- Sirtuins and Resveratrol in Medicine
- Cancer survivorship and care
- Urinary and Genital Oncology Studies
- Menstrual Health and Disorders
- FOXO transcription factor regulation
Dankook University
2015-2018
Cheil General Hospital and Women's Healthcare Center
2015-2018
Seoul National University
2008-2015
Gachon University
2010-2012
Institute of Molecular Biology and Genetics
2012
Sungkyunkwan University
2011
Samsung Medical Center
2011
Seoul National University Hospital
2008-2010
Charles R. Drew University of Medicine and Science
2010
National Cancer Center
2006
To estimate the effects of vaginal pH-balanced gel on symptoms and atrophy in breast cancer survivors treated with chemotherapy or endocrine therapy.This was a randomized, double-blind, placebo-controlled study. Breast who experienced menopause after therapy were voluntarily enrolled randomly administered topical placebo three times per week for 12 weeks. Vaginal dryness dyspareunia measured by visual analog scale, health index, pH. The endometrium ovary evaluated transvaginal...
Clinical practice guidelines for gynecologic cancers have been developed by many organizations.Although these much in common terms of the standard care uterine corpus cancer, that reflect characteristics patients and healthcare insurance systems are needed each country.The Korean Society Gynecologic Oncology (KSGO) published first edition cancer treatment late 2006; second was released July 2010 as an evidence-based recommendation.The Guidelines Revision Committee established 2015 decided to...
Abstract Aim Human epididymis protein 4 (HE4) is a novel biomarker for epithelial ovarian cancer. This study was designed to evaluate the role of HE4 in chemo‐response against anti‐cancer drugs and prognosis Methods HE4‐depleted cells HE4‐overexpressing were generated. The effect gene silencing overexpression examined using cell viability assay after exposure chemotherapeutic agents signaling pathway. We studied expression cancer tissue prognostic significance. Cytoplasmic staining graded...
BubR1 acetylation is essential in mitosis. Mice heterozygous for the acetylation-deficient allele (K243R/+) spontaneously developed tumors with massive chromosome missegregations. K243R/+ mouse embryonic fibroblasts (MEFs) exhibited a weakened spindle assembly checkpoint (SAC) shortened mitotic timing. The generation of SAC signal was intact, as Mad2 localization to unattached kinetochore (KT) unaltered; however, because premature degradation K243R-BubR1, complex disassociated prematurely...
High dysadherin expression has been recognized as a biological predictor of metastasis and poor prognosis for many different cancer types; however, the molecular mechanisms how affects progression are still poorly understood. In this study, we examined whether AKT signaling could link with downstream events that promote metastatic potential human breast cells. Immunohistochemical analysis tissues showed was highly associated elevated phospho-AKT. The introduction cDNA into BT-474, MCF-7...
Objective To evaluate the histologic correlation and clinical significance of atypical glandular cells (AGC) detected on Pap tests. Methods tests interpreted as AGC were retrieved from an institutional cytopathology database. The subcategories according to Bethesda system 2001 include cells, not otherwise specified (AGC‐NOS), endometrial (AEM), endocervical (AEC). Clinicopathologic variables collected medical records retrospectively, follow‐up diagnoses correlated with subcategories. Results...
A subset of cancer cells maintains telomere lengths in a telomerase-independent manner known as the alternative lengthening telomeres (ALT). The goal this study was to evaluate frequency ALT uterine sarcoma and carcinosarcoma assess its association with clinical parameters.Retrospectively collected paraffin blocks from 41 patients sarcomas carcinosarcomas were analyzed for ALT-associated promyelocytic leukemia bodies (APBs), which are significant feature cells, using combined...
Primary vulva malignancy is a rare gynecologic malignancy. Most of them are squamous cell carcinomas and adenocarcinomas much less common. Intestinal type variant primary adenocarcinoma the vulva. It histologically resembles mucinous colonic carcinomas. Origin from cloacal remnants has been suggested but remains speculative. A 64-year-old woman was referred to our clinic with 1-month history an itching mass. An incisional biopsy performed at other hospital disclosed intestinal type....
Purpose The purpose of this study is to evaluate the impact high-risk human papillomaviruses (HPVs) other than HPV 16/18 on natural course atypical squamous cells undetermined significance (ASC-US) or low-grade intraepithelial lesion (LSIL). Materials and Methods population was derived from Korean cohort (2010-2014). Women aged 20 60 who satisfied criteria having both infection abnormal cervical cytology either ASC-US LSIL were recruited five institutions nationwide. Enrolled patients...
To assess the efficacy and safety of human placenta extract in relief climacteric symptoms.A prospective, randomized, double-blind, placebo-controlled trial was performed on 108 women with menopausal symptoms. Human or placebo administered to for 4 weeks. Climacteric symptoms were assessed Kupperman Index (KMI).Both groups showed a significant reduction KMI score at end treatment. However, decrease significantly greater product group than (-12.30 +/- 10.44 vs -7.15 9.11, P = 0.012) after...
Objective This study investigated the prevalence of infections with human papillomavirus, Chlamydia trachomatis, Ureaplasma urealyticum, Mycoplasma hominis, and genitalium in semen Korean infertile couples their associations sperm quality. Methods Semen specimens were collected from 400 men who underwent a fertility evaluation. Infection above five pathogens was assessed each specimen. Sperm quality compared pathogen-infected group non-infected group. Results The infection rates C. U. M....
The aim of this study is to investigate the correlation between ATP-based chemotherapy response assay (ATP-CRA) results and clinical outcomes in ovarian cancer. Twenty-nine fresh tumor specimens were collected. Tumor cells isolated cultured for 48 hrs medium containing anticancer drugs. median age patients was 56 years. sensitivity, positive predictive value, accuracy ATP-CRA respectively 94.1%, 90.0%. There a significant relationship responses (p = 0.046). This suggests that has high predicting
DNA methylation has been shown to be a potential biomarker for early cancer detection. The aim of this study was evaluate profiles according liquid-based Pap (LBP) test results and assess their diagnostic value in Korean population. A total 205 patients with various Papanicolaou were enrolled (negative, 26; atypical squamous cells undetermined significance, 39; low grade intraepithelial lesion, 44; high lesion (HSIL), 48; cancer, 48). analysis four genes, ADCYAP1, PAX1, MAL, CADM1, performed...
Pelvic actinomycosis is an uncommon disease in humans. It has nonspecific and variable clinical features, thus it difficult to diagnose. Moreover, appropriate management delayed or overlooked because can sometimes simulate advanced ovarian cancer. We report a case of pelvic which manifested with hydronephrosis bowel stricture, lymph node enlargement increased level tumor marker caused by large mass. Since this showed findings mimicking carcinoma, was surgically diagnosed as after neoadjuvant...
We report a case of early non-invasive diagnosis acute eosinophilic myopericarditis (AEM) by cardiovascular magnetic resonance (CMR) before cardiac biopsy. A 35-yr-old woman presented with flu-like illness, followed pleuritic chest pain and shortness breath. Transthoracic echocardiography revealed mild left ventricular (LV) systolic dysfunction borderline LV wall thickness moderate pericardial effusion. The patient had peripheral eosinophilia CMR was performed immediately at first day visit...
The purpose of this study was to compare the accuracy pelvic examination versus imaging modality such as computed tomography (CT) or magnetic resonance (MRI) in measurement tumor size invasive cervical carcinoma based on pathologic findings.Patients with stage Ib-II cancer who underwent primary surgical treatment between January 2003 and December 2005 were evaluated retrospectively. One hundred three consecutive patients aged 24 81 years (mean age, 50.6 years), had not received any...
This study was to identify the risk factors for cytological progression in women with atypical squamous cells of undetermined significance (ASC-US) or low-grade intraepithelial lesions (LSIL).We analyzed data from infected human papillomavirus (HPV) who participated Korean HPV cohort study. The recruited aged 20-60 years abnormal cervical cytology (ASC-US LSIL) April 2010. All were followed-up at every 6-month intervals and DNA testing.Of 1,158 included, 654 (56.5%) 504 (43.5%) showed ASC-US...
Objective The aim of this study was to evaluate the surgical and obstetrical outcomes patients with early cervical cancer who underwent laparoscopic radical trachelectomy pelvic lymphadenectomy. Methods We analyzed data from women lymphadenectomy between July 2000 October 2014. Results Of a total 12 patients, 91.7% were FIGO (International Federation Gynecology Obstetrics) stages IA2 IB1. Seven (58.3%) had squamous cell carcinoma. median tumor size 1.87 cm (range, focal 4.6 cm) two (16.7%)...
Ovarian carcinosarcoma is a rare subtype of this disease that has not been thoroughly investigated. The aim study was to evaluate the prognostic factors and out comes in patients with ovarian carcinosarcoma.All histologically confirmed who were treated at Cheil General Hospital Women's Healthcare Center between January 2000 December 2015 identified analyzed. Data extracted from medical records, statistical analyses performed determine correlations clinicopathological parameters survival...
Epithelial ovarian cancers (EOCs) are highly lethal gynecological malignancies with a high recurrence rate. Therefore, developing prognostic markers for after chemotherapy is crucial the treatment of cancers. As frequently respond to DNA-damaging agents, we assessed clinicopathological significance key double-strand DNA break (DSB) repair genes, including BRCA1, BRCA2, BARD1, ATM, RAD51 and NBS1 in EOC cell lines paraffin-embedded tissue sections from 140 patients treated cytoreductive...