A5071676695- Cancer Cells and Metastasis
- Wnt/β-catenin signaling in development and cancer
- TGF-β signaling in diseases
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Cytokine Signaling Pathways and Interactions
- Lung Cancer Treatments and Mutations
- Cancer, Hypoxia, and Metabolism
- Liver physiology and pathology
- Ginkgo biloba and Cashew Applications
- Pancreatic and Hepatic Oncology Research
- Genetic factors in colorectal cancer
- Microtubule and mitosis dynamics
- Bone and Dental Protein Studies
- Neurological Disease Mechanisms and Treatments
- Natural product bioactivities and synthesis
- Bone Metabolism and Diseases
- Genomics, phytochemicals, and oxidative stress
- Cancer Research and Treatments
- Kruppel-like factors research
- Animal Genetics and Reproduction
- NF-κB Signaling Pathways
- Nutrition, Genetics, and Disease
- Endoplasmic Reticulum Stress and Disease
- MicroRNA in disease regulation
Gwangju Institute of Science and Technology
2016-2025
Gachon University
2008-2023
Cancer Genetics (United States)
2008-2023
National Cancer Institute
2006-2023
Sungkyunkwan University
2022
Charles R. Drew University of Medicine and Science
2010-2013
Pukyong National University
2009
Jeonju University
2009
National Cancer Institute
2004-2007
National Institutes of Health
2007
Abstract The identification of cancer stem cells (CSCs) represents an important milestone in the understanding chemodrug resistance and recurrence. More specifically, some studies have suggested that potential metastasis-initiating (MICs) might be present within small CSC populations. targeting eradication these a strategy for significantly improving clinical outcomes. A number dysregulation Wnt/β-catenin signaling occurs human breast cancer. Consistent with findings, our previous data shown...
Radiotherapy (RT) is a highly effective multimodal nonsurgical treatment that essential for patients with advanced colorectal cancer (CRC). Nevertheless, cell subpopulations displaying intrinsic radioresistance survive after RT. The reactivation of their proliferation and successful colonization at local or distant sites may increase the risk poor clinical outcomes. Recently, radioresistant cells surviving RT were reported to exhibit more aggressive phenotype than parental cells, although...
Flavonols are compounds that have been shown to possess potent anti‑inflammatory effects in cellular and animal models of inflammation. In the present study, mechanisms two natural flavonols, quercetin galangin, lipopolysaccharide (LPS)‑stimulated RAW264.7 macrophages were investigated. It was identified galangin markedly reduced production nitric oxide (NO), inducible NO synthase interleukin‑6, nuclear translocation factor‑κB (NF‑κB). addition, LPS‑induced activation extracellular...
Abstract Overexpression of the immunosuppressive cytokine transforming growth factor β (TGF-β) is one strategy that tumors have developed to evade effective immunesurveillance. Using transplantable models breast and colon cancer, we made unexpected finding CD8+ cells in tumor-bearing animals can directly promote tumorigenesis, by a mechanism dependent on TGF-β. We showed splenocytes from mice expressed elevated interleukin (IL)-17 when compared with naive mice, T could be induced make IL-17...
Overexpression of transforming growth factor beta (TGF-beta) is frequently associated with metastasis and poor prognosis, TGF-beta antagonism has been shown to prevent in preclinical models surprisingly little toxicity. Here, we have used the transplantable 4T1 model metastatic breast cancer address underlying mechanisms. We showed that efficacy anti-TGF-beta antibody 1D11 suppressing was dependent on a synergistic combination effects both tumor parenchyma microenvironment. The main outcome...
Breast cancer stem cells (BCSC) are resistant to conventional chemotherapy and radiotherapy, which may destroy tumor masses but not all BCSC that can mediate relapses. In the present study, we showed level of Wnt/β-catenin signaling in is relatively higher than bulk cells, contributing a therapeutic resistance. We designed highly potent small-molecule inhibitor, CWP232228, antagonizes binding β-catenin T-cell factor (TCF) nucleus. Notably, although CWP232228 inhibited growth both by...
The cancer stem cell (CSC) hypothesis proposes that CSCs are responsible for metastasis and disease recurrence. Therefore, targeting has the potential to significantly improve outcomes patients. OCT4 transcription factor gene is a master plays key role in self-renewal pluripotency of cells. In this study, we introduced an reporting vector into 4T1 mouse breast cells sorted high low populations. We then determined whether expression associated with maintenance expansion CSCs. found OCT4high...
Abstract Advanced tumors produce an excessive amount of transforming growth factor β (TGFβ), which promotes tumor progression at late stages malignancy. The purpose this study was to develop anti-TGFβ therapeutics for cancer. We synthesized a novel small-molecule TGFβ receptor I kinase (activin receptor–like 5) inhibitor termed N-[[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl]methyl]-2-fluoroaniline (EW-7197), and we investigated its potential...
The purpose of this study was to determine the effects baicalein and wogonin, which are compounds derived from Chinese herb Scutellaria baicalensis, in suppressing viability HT-29 human colon cancer cells. Following treatment with or several apoptotic events were observed, including DNA fragmentation, chromatin condensation increased cell cycle arrest G1 phase. Baicalein wogonin decreased Bcl-2 expression, whereas expression Bax a dose-dependent manner compared control. Furthermore,...
Cervical cancer is the third most common and leading cause of death among women. However, standard treatment for cervical includes cisplatin, which can side effects such as hematological damage or renal toxicity. New innovations in focus on developing more effective better-tolerated therapies Sp1-targeting drugs. Previous studies suggested that mithramycin A (Mith) inhibits growth various cancers by decreasing Sp1 protein. how protein decreased Mith not clear. Few have investigated...
Background/Aim: Piperine is a major pungent alkaloid present in black pepper (Piper nigrum L). This study investigated the potential anticancer effects of piperine on human melanoma cells and explored pharmacological mechanisms vitro vivo. Materials Methods: Studies were performed using MTT assay, 4',6-diamidino-2-phenylindole (DAPI) staining, western blotting, xenograft model, terminal deoxynucleotidyl transferase dUTP nick end labeling immunohistochemistry. Results: inhibited growth cells....
Liver cancer stem cells (CSCs) are resistant to conventional chemotherapy and radiation, which may destroy tumor masses, but not all liver CSCs contribute initiation, metastasis, relapse. In the present study, we showed that with elevated Wnt/β-catenin signaling possess much greater self-renewal clonogenic potential. We further documented increased potential of is highly associated changes in activity positively correlated CD133 expression aldehyde dehydrogenase (ALDH) enzymatic activity....
Abstract Hypoxia, a feature common to most solid tumors, is known regulate many aspects of tumorigenesis. Recently, it was suggested that hypoxia increased the size cancer stem-cell (CSC) subpopulations and promoted acquisition CSC-like phenotype. However, candidate hypoxia-regulated mediators specifically relevant stemness-related functions colorectal CSCs have not been examined in detail. In present study, we showed self-renewal potential CSCs. Through various vitro studies, found...
Abstract Dysadherin, a cancer-associated membrane glycoprotein, down-regulates E-cadherin and promotes cancer metastasis. This study examined the role of dysadherin in breast progression. Expression was found to be highest cell lines tumors that lacked estrogen receptor (ER). Knockdown caused increased association with actin cytoskeleton expressed E-cadherin. However, knockdown could still suppress invasiveness cells had no functional E-cadherin, suggesting existence novel mechanism action....
Abstract The transforming growth factor-β (TGF-β) pathway has tumor-suppressor activity in many epithelial tissues. Because TGF-β is a potent inhibitor of cell proliferation, it been widely assumed that this property underlies the effect. Here, we have used xenograft model breast cancer to show endogenous potential suppress tumorigenesis through novel mechanism, involving effects at two distinct levels hierarchy cellular progeny make up component tumor. First, reduces size putative stem or...
Abstract Transforming growth factor βs (TGF-β) play a dual role in carcinogenesis, functioning as tumor suppressors early the process, and then switching to act prometastatic factors late-stage disease. We have previously shown that high molecular weight TGF-β antagonists can suppress metastasis without predicted toxicities. To address underlying mechanisms, we used 4T1 syngeneic mouse model of metastatic breast cancer. Treatment mice with monoclonal anti-TGF-β antibody (1D11) significantly...
Bone marrow-derived mesenchymal stem cells (BM-MSCs) are often recruited to solid tumors, integrate into the tumor stroma, and contribute development. TNFα is a major inflammatory cytokine present in microenvironment has profound influence on progression of This study was aimed investigate role BM-MSCs promotion response TNFα. Quantitative real-time PCR arrays show that diverse cytokines/chemokines were induced TNFα-treated BM-MSCs; particular, CXCR3 ligand chemokines, including CXCL9,...
Tropomyosin-related kinase (Trk) C, a member of the Trk family neurotrophin receptors, has been implicated in growth and survival human cancer tissues. Here, we report that TrkC is frequently overexpressed breast cancers plays an essential role tumor metastasis. Ectopic expression non-malignant mammary epithelial cells suppressed anoikis, which correlated with activation Ras-mitogen-activated protein phosphatidylinositol-3-OH (PI3K)/Akt pathways, reduced metastatic regulator Twist....