ABSTRACT Porphyromonas gingivalis is a major etiological agent of periodontal disease, and infections with this bacterium are associated systemic pathologies, including atherosclerosis, rheumatoid arthritis, Alzheimer’s disease. P. has variety immune evasion mechanisms exhibits highly variable cell surface characteristics that strain dependent, complicating the development effective vaccines therapeutics. Here, we show subset immunoglobulin M (IgM) antibodies in antiserum raised against W83...

Amla (Emblica officinalis Gaertn.) is widely used in Indian medicine for the treatment of various diseases. We have investigated effects amla on lipid metabolism and protein expression involved oxidative stress during ageing process. SunAmla or ethyl acetate extract amla, a polyphenol-rich fraction, was administered at dose 40 10 mg/kg body weight per d 100 to young rats aged 2 months months. The levels, such as cholesterol TAG, serum liver were markedly elevated control rats, while they...

In order to investigate the thermal degradation of glucose and maltose solutions after high temperature pressure (HTHP) treatment, samples were treated at temperatures 110, 120, 130, 140, 150°C for 1, 2, 3, 4, 5 h in an apparatus HTHP treatment. Glucose (20% w/w) prepared by weighing adding distilled water desired proportion. Chromaticity, pH, organic acids, 5-hydroxymethylfurfural (HMF), free sugar contents, electron donating ability (EDA), ascorbic acid equivalent antioxidant capacity...

This study aims to investigate the protective effects and mechanisms of pectolinarin against oxidative stress-induced cell damage in SH-SY5Y cells. Neurodegenerative diseases-such as Alzheimer's disease-are potentially associated with stress, which causes excessive production reactive oxygen species (ROS) that DNA proteins neuronal The results this demonstrate can scavenge hydroxyl nitric oxide radicals a concentration-dependent manner. Moreover, significantly increased viability while...

The effects of amla on low-density lipoprotein (LDL) oxidation and cholesterol levels were investigated in vitro vivo using C2+-induced LDL choles terol-fed rats. SunAmla ethyl acetate (EtOAc) extract significantly inhibited thiobarbituric acid (TBA)-reactive substance level the Cu2+-induced stronger than those probucol. In addition, administration (at a dose 20 or 40mg/kg body weight/d) EtOAc 10 20mg/kg for d to rats fed 1% diet reduced total, free LDL-cholesterol dose-dependent manner,...

To investigate the effects of amla on renal dysfunction involved in oxidative stress during aging process, we employed young (2 months old) and aged (13 male rats administered SunAmla (Taiyo Kagaku Co., Ltd., Japan) or an ethyl acetate (EtOAc) extract amla, a polyphenol-rich fraction, at dose 40 10 mg/kg body weight/day for 100 days. The administration EtOAc reduced elevated levels serum creatinine urea nitrogen rats. In addition, tail arterial blood pressure was markedly control as compared...

In our previous study, we reported the renoprotective effect of Hachimi-jio-gan, a Chinese traditional prescription consisting eight medicinal plants, and also Corni Fructus (Cornus officinalis SIEB. et ZUCC.), component on diabetic nephropathy using rats. this investigated effects morroniside isolated from renal damage in streptozotocin-treated Oral administration at dose 20 or 100 mg/kg body weight/d for d to rats resulted significant decreases increasing serum glucose urinary protein...

We investigated the effects of amla ( Emblica officinalis Gaertn.) on fructose-induced metabolic syndrome using a rat model. Male Wistar rats were fed high-fructose (65 %) diet or standard chow for 1 week, and treated with an ethyl acetate (EtOAc) extract amla, polyphenol-rich fraction, at 10 20 mg/kg body weight per d, vehicle, 2 weeks. Serum glucose, TAG, total cholesterol blood pressure levels diet-fed increased compared those normal P < 0·001). However, EtOAc ameliorated high...

Barley sprouts are 5- to 20-day-old grown whole plants that widely consumed as a functional vegetable due their health-promoting compounds such saponarin, γ-Aminobutyric acid (GABA), and policosanols. Recent plasma applications have been promising approach in the agricultural food industries produce bioactive phytochemicals sprouted crops. Therefore, this study investigated effects on plant its compared with those of an untreated control barley sprouts. The optimal exposure during seed...

To investigate the effects of isorhamnetin 3,7-di-O-beta-D-glucopyranoside (isorhamnetin diglucoside), a major flavonoid compound mustard leaf, on oxidative stress due to diabetes mellitus, in vivo and vitro studies were carried out. Oral administration diglucoside (10 or 20 mg/kg body weight/day for 10 days) rats with streptozotocin-induced significantly reduced serum levels glucose 5-(hydroxymethyl)furfural (5-HMF), which is glycosylated hemoglobin an indicator stress. After...

Oxidative damage induced by beta-amyloid (Abeta) is closely associated with the hallmark pathologies of Alzheimer's disease (AD) and may play a critical role in development AD. In this study, protective effects vitisin A heyneanol A, resveratrol oligomers isolated from Vitis amurensis Rupr. (Vitaceae), against Abeta-induced oxidative cell death were investigated using rat pheochromocytoma (PC12) cells. Exposure PC12 cells to Abeta (20 microM) for 24 h resulted neuronal death, whereas...

Brevilin A, which has anticancer activities against a range of cancers, is an abundant constituent the medicinal herb Centipeda minima (L.) A. Braun & Asch, also been reported to have activity breast cancer cells. However, C. and brevilin A human gastric yet be reported. In this study, we aimed evaluate cytotoxicity molecular basis underlying extracts (CMX) (AGS) We deduced potential targets mechanisms based on network pharmacology approach. CCND1, CDK4, BCL2L1 were identified as key genes...

Alzheimer’s disease (AD) is a neurodegenerative accompanied by neuroimmune inflammation in the frontal cortex and hippocampus. Recently, presence of bacteria AD-affected brains has been documented, prompting speculation about their potential role AD-associated neuroinflammation. However, characterization bacteriota human affected AD remains inconclusive. This study aimed to investigate associations between specific pathology examining brain tissues from regions (frontal hippocampus)...

The effects of dried Rehmanniae Radix (Di Huang) extract were investigated using a diabetic nephropathy model: rats given streptozotocin after nephrectomy. results showed that this crude drug reduced the magnitudes increases in glucose, urea nitrogen, 5-hydroxymethylfurfural and thiobarbituric acid (TBA)-reactive substance levels, with being most marked high blood glucose group. renal histopathological lesions, which conspicuous not extract, ameliorated considerably group extract. It appears...

We evaluated antioxidant activities of heated pear juice (HPJ) exposed to 120, 130, and 140℃ for 2 hr. HPJ was partitioned using n-hexane, chloroform, ethyl acetate, n-butanol, water. The acetate fraction treated at 130℃ hr showed strong activity; thus, this extract isolated purified silica gel column chromatography preparative high performance liquid chromatography. structure the compound determined ultraviolet mass spectrometry, ¹H-nucelar magnetic resonance (NMR), ¹³C-NMR. Antioxidant...

This study was performed to isolate and identify a compound with antiproliferative activity against human stomach cancer cell lines, from fructose-tryptophan Maillard reaction products (MRPs). The MRPs, prepared solution heated at 130 °C for 2 h, were fractionated into five solvent fractions: n-hexane, chloroform, ethyl acetate, butanol, water. highest found in the chloroform fraction (85.93% 200 μg/mL), active this purified by silica gel column chromatography, TLC, preparative HPLC. (IC50)...

This study was performed to evaluate and compare the antioxidant substance content activities of white (Superior) colored (Hongyoung, Jayoung, Jasim, Seohong, Jaseo) potatoes. The potatoes were extracted with 80% ethanol evaluated for total polyphenol, flavonoid, anthocyanin contents 1,1-diphenyl- 2-picrylhydrazyl (DPPH)/2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) radical scavenging activity, reducing power, ferrous metal ion chelating effect. Hongyoung...