A5085019914- Gallbladder and Bile Duct Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Skin and Cellular Biology Research
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Gastric Cancer Management and Outcomes
- Liver physiology and pathology
- Thyroid Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Helicobacter pylori-related gastroenterology studies
- Cancer Diagnosis and Treatment
- Microtubule and mitosis dynamics
- Renal cell carcinoma treatment
- Fibroblast Growth Factor Research
- Pancreatitis Pathology and Treatment
- Urinary and Genital Oncology Studies
- Medical Imaging and Pathology Studies
- Bladder and Urothelial Cancer Treatments
- Cancer and Skin Lesions
- Soft tissue tumor case studies
- Genetics and Neurodevelopmental Disorders
Yonsei University
2016-2025
Gangnam Severance Hospital
2014-2025
CHA University
2024
Soonchunhyang University
2024
CHA Bundang Medical Center
2024
The University of Texas Health Science Center at Houston
2024
Memorial Hermann
2024
Inha University
2024
Inha University Hospital
2022
Severance Hospital
2013-2020
Keratin (KRT) 19 is a poor prognostic marker for hepatocellular carcinoma (HCC); however, regulatory mechanisms underlying its expression remain unclear. We have previously reported the presence of fibrous tumor stroma in KRT19-positive HCC, suggesting that cross-talk between cancer-associated fibroblasts (CAF) and epithelial cells could regulate KRT19 expression. This was investigated this study using an vitro model paracrine interaction HCC cell lines (HepG2, SNU423) hepatic stellate...
We aimed to demonstrate the differences in expression of glucose metabolism–related proteins according thyroid cancer subtypes and investigate implications these differences. A total 566 patients, including 342 cases papillary carcinoma, 112 follicular 70 medullary 23 poorly differentiated 19 anaplastic 152 adenoma, were enrolled study. Immunohistochemical staining for transporter 1, hexokinase II, carbonic anhydrase IX, monocarbonylate 4 was performed, relationship between immunoreactivity...
Abstract Background & Aims Intrahepatic cholangiocarcinoma ( iCCA ) is a heterogeneous entity with diverse aetiologies, morphologies and clinical outcomes. Recently, histopathological distinction of cholangiolocellular differentiation CD has been suggested. However, its genome‐wide molecular features significance remain unclear. Methods Based on status, we stratified s into (n=20) without (n=102), performed an integrative analysis using transcriptomic clinicopathological profiles....
The Bethesda System for Reporting Thyroid Cytopathology (BSRTC) uses six diagnostic categories to standardize communication of thyroid fine-needle aspiration (FNA) interpretations between clinicians and cytopathologists. Since several studies have questioned the accuracy this system, we examined its in our hospital.We calculated incidences malignancy rates each category BSRTC 1,730 FNAs that were interpreted by four cytopathologists Gangnam Severance Hospital October 1, 2011, December 31,...
Senescence secretome was recently reported to promote liver cancer in an obese mouse model. Steatohepatitic hepatocellular carcinoma (SH-HCC), a new variant of HCC, has been found metabolic syndrome patients, and pericellular fibrosis, characteristic feature SH-HCC, suggests that alteration the tumor stroma might play important role SH-HCC development. Clinicopathological characteristics showing senescence senescence-associated secretory phenotype (SASP) were investigated 21 SH-HCCs 34...
Hepatocellular carcinoma (HCC) undergoes a stepwise progression from liver cirrhosis to low-grade dysplastic nodule (LGDN), high-grade (HGDN), early HCC (eHCC), and progressed (pHCC). Here, we profiled multilayered genomic, epigenomic, transcriptomic aberrations in the hepatocarcinogenesis. Initial DNA methylation was observed eHCC (e.g., DKK3, SALL3, SOX1) while more extensive pHCC. In addition, eHCCs showed an initial loss of copy numbers tumor suppressor genes 4q 13q regions, thereby...
ABSTRACT Background Helicobacter pylori infection is a significant contributing factor of gastric cancer. Metachronous neoplasms also pose risk. The mechanism underlying the impact H. eradication on preventing metachronous cancer unclear. This study aimed to investigate immunity changes in mucosa after and identify mechanisms recurrence. Materials Methods Patients diagnosed with neoplasm infection, who underwent endoscopic resection, were included. Thirty‐six cases occurring (metachronous...
Background: Eosinophilic esophagitis (EoE) is a disease that has been subcategorized into two endoscopic phenotypes: inflammatory and fibrostenotic. Moreover, studies have shown link between EoE immunoglobulin G4 (IgG4), subclass of the G (IgG) antibody. In this study, we aimed to evaluate relationship histologic IgG4 expression phenotypes in patients with EoE. Methods: This case-control study included diagnosed (n = 19) non-obstructive dysphagia without abnormal findings as controls (NOD; n...
Well-differentiated papillary mesothelioma is an uncommon subtype of with a frequently indolent course, although it occasionally manifests in more aggressive form. To establish treatment strategy for this rare disease, we report the clinical characteristics and outcomes 15 patients well-differentiated mesothelioma.All pathologically diagnosed cases were reviewed between 1998 2012.Of cases, 8 7 presented single multiple lesions, respectively. All lesions asymptomatic, while 4 out symptomatic....
We aimed to evaluate the histologic and radiologic findings of vascular lesions after stereotactic radiosurgery (SRS) categorized as radiation-induced cavernous hemangioma (RICH).Among 89 patients who underwent neurosurgery for hemangioma, eight RICHs from 7 10 de novo CHs were selected histopathological radiological comparison.Histologically, showed hematoma-like gross appearance. Microscopically, RICH exhibited a area accompanied by proliferation thin-walled vasculature with fibrin...
Reported incidence of extrahepatic bile duct cancer is higher in Asians than Western populations. Korea, particular, one the countries with highest rates world. Although research and innovative therapeutic modalities for are emerging, clinical guidelines currently unavailable Korea. The Korean Society Hepato-Biliary-Pancreatic Surgery collaboration related societies (Korean Pancreatic Biliary Society, Abdominal Radiology, Medical Oncology, Radiation Pathologists, Nuclear Medicine) decided to...
// Ji Hae Nahm 1, * , Hyungjin Rhee 2, 3, 4, Haeryoung Kim 5 Jeong Eun Yoo 7 Jee San Lee 4 Youngsic Jeon Gi Hong Choi 6 and Young Nyun Park 1 Department of Pathology, Yonsei University College Medicine, Seoul, Korea 2 Radiology, 3 Brain 21 PLUS Project for Medical Science, Integrated Genomic Research Center Metabolic Regulation, Seoul National Hospital, Departments General Surgery, Severance Biomedical Science Institute, These are contributed equally to this work Correspondence to: Park,...
A retrospective analysis was performed to describe the cytomorphological and histopathological findings human papillomavirus (HPV) genotypes for glassy cell carcinoma (GCC) of uterine cervix. Five cases cervical GCC, in which features constituted at least 95% specimen, were included. Four patients had stage IIB GCCs one IIIB GCC. All underwent concurrent chemoradiation therapy. Based on pretreatment cytology, only 1 5 correctly diagnosed as The remaining undetermined type, adenocarcinoma,...
Hippo signaling acts as a tumor suppressor pathway by inhibiting the proliferation of adult stem cells and progenitor in various organs. Liver-specific deletion components mice induces liver cancer development through activation transcriptional coactivators, YAP TAZ, which exhibit nuclear enrichment are activated numerous types cancer. The upstream-most regulators Warts,
A heterogeneous group of cancers for which the site origin remains occult after detailed investigations is defined as carcinomas unknown primary (CUPs). Because patients with CUP have a dismal prognosis, we analyzed CUPs to highlight implication clinicopathologic factors related patient survival. total 106 consecutive cases were collected. two-step strategy immunohistochemistry assess according NCCN Guidelines used separate carcinomatous tumors and subtype carcinomas. Median follow up...
Budd-Chiari syndrome is defined as hepatic venous outflow tract obstruction regardless of the level (anywhere between small veins to junction inferior vena cava and right atrium) or cause obstruction.1 It frequently associated with hepatomegaly, abdominal pain, ascites dysfunction, patients often demonstrate one more risk factors, including an underlying hypercoagulable state, vascular injury stasis, by neoplasm cirrhosis, amebic abscess, sarcoidosis etc. Hypercoagulable states include oral...
Treatment of benign biliary strictures (BBS) using fully covered self-expandable metal stents (FCSEMS) has a high success rate, but recurrence can occur. Corticosteroids may be useful based on their anti-fibrotic and anti-inflammatory effects. We investigated the safety efficacy corticosteroid-eluting FCSEMS in an animal model. BBSs were created by radiofrequency ablation 12 mini-pigs. Four weeks later, coated with 0 mg (control), 15 (steroid 1 × group), or 30 2 group) triamcinolone inserted...
Nuclear factor E2-related factor2 (Nrf2) activation is associated with both cytoprotective effects and malignant behavior of cancer cells. This study aimed to evaluate the clinicopathological implications expression Nrf2, pNrf2, its regulator Keap1 in human hepatocellular carcinomas (HCCs). Tissue microarrays consisting 285 surgically resected HCCs were immunohistochemically stained Keap1, stemness-related markers (keratin 19 (K19), epithelial cell adhesion molecule (EpCAM)), carbonic...