A5101734596- Pancreatic and Hepatic Oncology Research
- Glycosylation and Glycoproteins Research
- Gallbladder and Bile Duct Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Advanced Neuroimaging Techniques and Applications
- Ubiquitin and proteasome pathways
- Advanced MRI Techniques and Applications
- interferon and immune responses
- Galectins and Cancer Biology
- Cancer Treatment and Pharmacology
- Gastric Cancer Management and Outcomes
- Pediatric Hepatobiliary Diseases and Treatments
- Lung Cancer Research Studies
- Advanced Vision and Imaging
- Hepatocellular Carcinoma Treatment and Prognosis
- Sparse and Compressive Sensing Techniques
- Immune Cell Function and Interaction
- Cancer-related Molecular Pathways
- Oral and gingival health research
- Cancer Genomics and Diagnostics
- Immune Response and Inflammation
- Neuroendocrine Tumor Research Advances
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- RNA and protein synthesis mechanisms
Yonsei University
2005-2024
Kangdong Sacred Heart Hospital
2018-2024
Hallym University Medical Center
2018-2024
Seonam University
2015-2016
Seoul St. Mary's Hospital
2016
Jacobson Holman (United States)
2015
There is limited data on miRNA expression in pancreatic neuroendocrine tumors (PanNETs). In this study, we aimed to identify miRNAs that could be potential prognostic biomarkers of PanNETs patients who underwent curative surgery. For target screening, 2 primary and corresponding liver metastases were screened for by the NanoString nCounter analysis. Candidate selected ≥2-fold difference between metastatic versus tumor. validation, quantitative real-time PCR was performed candidate 37 matched...
Dysregulation of O-GlcNAcylation has emerged as a potential biomarker for several diseases, particularly cancer. The role OGT (O-GlcNAc transferase) in maintaining O-GlcNAc homeostasis been extensively studied; nevertheless, the regulation OGA (O-GlcNAcase) cancer remains elusive. Here, we demonstrated that multifunctional protein RBM14 is regulator cellular O-GlcNAcylation. By investigating correlation between elevated and increased expression lung cells, discovered promotes...
Previous studies reported increased incidence of gallstone formation after gastrectomy. However, there were few reports about factors other than surgical technique. The purpose this study is to investigate the spectrum risk From June 2003 December 2008, 1480 patients who underwent gastrectomy due gastric cancer but had no gallstones before surgery identified. Electronic medical records retrospectively reviewed. Gallstones assessed by computerized tomography or ultrasound performed as...
Reported incidence of extrahepatic bile duct cancer is higher in Asians than Western populations. Korea, particular, one the countries with highest rates world. Although research and innovative therapeutic modalities for are emerging, clinical guidelines currently unavailable Korea. The Korean Society Hepato-Biliary-Pancreatic Surgery collaboration related societies (Korean Pancreatic Biliary Society, Abdominal Radiology, Medical Oncology, Radiation Pathologists, Nuclear Medicine) decided to...
Post-translational modifications, including O -GlcNAcylation, play fundamental roles in modulating cellular events, transcription, signal transduction, and immune signaling. Several molecular targets of -GlcNAcylation associated with pathogen-induced innate responses have been identified; however, the direct regulatory mechanisms linking antiviral RIG-I-like receptor signaling are not fully understood. In this study, we found that levels decline response to infection Sendai virus. We...
Background/Aims: For the suspected choledocholithiasis, American Society for Gastrointestinal Endoscopy has proposed guidelines to assign risk based on clinical predictors. The study aimed assess usefulness of predictors choledocholithiasis set forth by in patients with intermediate choledocholithiasis. Methods: In 2014, 109 underwent endoscopic ultrasound. Their medical records were retrospectively reviewed. gold standard was retrograde cholangiopancreatography or follow-up. Results: Based...
Based on their anatomy, cholangiocarcinomas (CCAs) are classified into intrahepatic, hilar, and distal CCAs. Although the diagnosis treatment of each type CCA thought to be different, real-world data studies current practice limited. Therefore, this study was designed capture diagnosing treating perihilar in Korea.
MR images reconstruction need many samples that are sequentially sampled by phase encoding gradients in MRI system. takes long scan time, therefore, researchers have been studied to reduce time. Especially, the Compressed Sensing (CS) is used sparse and from fewer sampling data which k-space not fully sampled. Recently, an iterative technique based on Bregman method developed for denoising. The iteration improves Total Variation (TV) regularization gradually recovering fine scale structures...
e15762 Background: Although FOLFIRINOX and gemcitabine with nab-paclitaxel (GNP) are widely used in metastatic pancreatic cancer (MPC), the multi-center study comparing two regimens is rare. Recently, a multi-center, web-based registry for (K-PaC, Korean cancer) was firstly launched South Korea. We aimed to compare clinical outcomes GNP MPC patients using K-PaC registry. Methods: In registry, we constructed database of anonymized 3,748 histologically-proven ductal adenocarcinoma. For this...
e15761 Background: Up to 35% of pancreatic cancers are considered ‘locally advanced’ (LAPC) at the time diagnosis. Replication-competent adenovirus-mediated double suicide gene therapy (Ad5-yCD/mutTK(SR39)rep-ADP) showed an anti-cancer effect in prostatic cancer patients previous studies. We aimed investigate tolerability and safety Ad5-yCD/mutTK(SR39)rep-ADP combination with gemcitabine LAPC. Methods: In this single-center, open label, dose-escalation phase I trial, we recruited adult (≥18...
Phase Contrast MR Angiography (PC MRA) takes longer scan time than other MRA technique. Especially, the 3D PC images obtaining at low tesla MRI system more long because lower characteristic of hardware high system. The keyhole imaging was introduced that is a simple way to increase temporal resolution dynamic studies. In this study, we applied technique for improving We also validated image quality and usefulness combination two techniques. All data were obtained on MagfinderII (Genpia,...
Reconstructing dynamic, time-varying scenes with computed tomography (4D-CT) is a challenging and ill-posed problem common to industrial medical settings. Existing 4D-CT reconstructions are designed for sparse sampling schemes that require fast CT scanners capture multiple, rapid revolutions around the scene in order generate high quality results. However, if moving too fast, then occurs along limited view difficult reconstruct due spatiotemporal ambiguities. In this work, we design...
Phase Contrast MR Angiography (PC MRA) is excellent MRA technique for measuring the velocity of vessels in human body. PC need to at least 4 images angiogram reconstruction and it caused longer scan time. Therefore, we used keyhole imaging combined reduce However, can lead erroneous effects as loss phase information or frequency discontinuous. In this study, applied 2D improving temporal resolution also measured evaluate accuracy information. We 0.32T MRI scanner (MagfinderII, Genpia,...
Throughtout the last three decades, therapy of leukemias and lymphoma has set stage for curative cancer in systemic malignant disease. This was result an integrated work basic reaserch clinical investigators leading to more aggressive albeit tolerable protocol chemotherapy radiotherapy. High dose marks most elaborated strategies this field today. However, intensification conventional therapeutic modalities as mentioned be based on new approaches exploration antineoplastic mechanisms. insight...
e15658 Background: Hilar cholangiocarcinoma (HC) is known to have a poor prognosis due cholangitis and lack of effective chemotherapeutic regimen. Since 2010, gemcitabine plus cisplatin (GP) recommended as first-line chemotherapy in cholangiocarcinoma. However, it still unclear whether GP on HC. We aimed evaluate the impact unresectable HC patients according biliary drainage (EBD). Methods: From 2010 2016, 112 with confirmed by biopsy at three tertiary referral hospitals Korea were enrolled....
e15729 Background: Although FOLFIRINOX showed improved efficacy in advanced pancreatic ductal adenocarcinoma (PDA), physicians still hesitate to administrate elderly patients despite of being a good performance status. We investigated the and toxicity with PDA. Methods: retrospectively reviewed electronic medical records PDA administrated first-line from January 2012 July 2017 single tertiary teaching hospital. All were divided into two groups: non-elderly group A (age < 70) B (age≥70)....