Portable, embedded systems place ever-increasing demands on high-performance, low-power microprocessor design. Dynamic voltage and frequency scaling (DVFS) is a well-known technique to reduce energy in digital systems, but the effectiveness of DVFS hampered by slow transitions that occur order tens microseconds. In addition, recent trend towards chip-multiprocessors (CMP) executing multi-threaded workloads with heterogeneous behavior motivates need for per-core control mechanisms. Voltage...

On-chip DC-DC converters have the potential to offer fine-grain power management in modern chip-multiprocessors. This paper presents a fully integrated 3-level converter, hybrid of buck and switched-capacitor converters, implemented 130 nm CMOS technology. The converter enables smaller inductors (1 nH) than buck, while generating wide range output voltages compared 1/2 mode converter. test-chip prototype delivers up 0.85 A load current from 0.4 1.4 V 2.4 input supply. It achieves 77% peak...

Abstract A long-standing question in the field of tumor immunotherapy is how Th2 cytokines block growth. Their antitumor effects are particularly prominent when they secreted continuously tumors, suggesting that may create a microenvironment unfavorable for growth independently adaptive immunity. In this study, we show local production IL-33 establishes high number type 2 innate lymphoid cells (ILC2s) with potent activity. promotes secretion massive amount CXCR2 ligands from ILC2s but...

In recent years, chip multiprocessor architectures have emerged to scale performance while staying within tight power constraints. This trend motivates per core/block dynamic voltage and frequency scaling (DVFS) with fast transition. Given the high cost bulk of off-chip DC/DC converters implement multiple on-chip domains, there has been a surge interest in converters. paper presents design experimental results fully integrated 3-level converter that merges characteristics both inductor-based...

Parameter variations have become a dominant challenge in microprocessor design. Voltage variation is especially daunting because it happens so rapidly. We measure and characterize voltage running Intel Core2 Duo processor. By sensing on-die as the processor runs single-threaded, multi-threaded, multi-program workloads, we determine average supply swing of to be only 4 percent, far from processor's 14percent worst-case operating margin. While such large margins guarantee correctness, they...

Abstract IL-33 is known to play an important role in Th2 immunity. In this study, we investigated the effect of pretreatment on anti-fungal response using acute Candida albicans peritoneal infection model. induced a rapid fungal clearance and markedly reduced C. infection-associated mortality. The priming occurred during multiple steps neutrophil-mediated response. First, due massive recruitment neutrophils site as result release CXCR2 chemokines by macrophages reversal TLR-induced reduction...

Diarylalkynones were synthesized from one-pot Pd-catalyzed carbonylative and noncarbonylative coupling reactions of propiolic acid with aryl iodides under a carbon monoxide atmosphere. Aryl iodide (2.0 equiv), (1.0 Pd(PPh3)2Cl2 (5 mol %), CuCl (10 Et3N (6.0 CO (8 atm) reacted optimized conditions in CH3CN at 80 °C for 1 h. This process afforded good yields functional group tolerance.

We introduce a novel linear bandit problem with partially observable features, resulting in partial reward information and spurious estimates. Without proper address for latent part, regret possibly grows linearly decision horizon $T$, as their influence on rewards are unknown. To tackle this, we propose analysis to handle the features an algorithm that achieves sublinear regret. The core of our involves (i) augmenting basis vectors orthogonal observed feature space, (ii) introducing...

Inflammation is defined as a physiological response initiated by variety of conditions that cause insult to the body, such infection and tissue injury. triggered specialized receptors in innate immune system, which recognize microbial components known pathogen-associated molecular patterns or endogenous signals produced damaged cells (damage-associated patterns). IL-33 cytokine released predominantly at epithelial barrier when it exposed pathogens, allergens, injury-inducing stimuli. target...

Although many previous studies have examined the effect of sporting events on destination image, relatively a limited number image events. Therefore, this study attempted to identify mediating relationship between spectator satisfaction and behavioral intentions, including word-of-mouth (WOM) revisit at an international event, Formula 1 Chinese Grand Prix (F-1). The results indicated that effects WOM repurchase intentions were found be mediated by spectators' reported images. Destination...

Abstract Alkynyl amides were synthesized from a palladium‐catalyzed coupling reaction of alkynyl carboxylic acids and amines under carbon monoxide. The was conducted with palladium(II) acetate (5 mol‐%) silver(I) oxide (1.0 equiv.) in acetonitrile at 80 °C for 1 h. This method provides good to moderate product yields functional group tolerance towards ketone, ester, nitrile groups.

Dysregulation of O-GlcNAcylation has emerged as a potential biomarker for several diseases, particularly cancer. The role OGT (O-GlcNAc transferase) in maintaining O-GlcNAc homeostasis been extensively studied; nevertheless, the regulation OGA (O-GlcNAcase) cancer remains elusive. Here, we demonstrated that multifunctional protein RBM14 is regulator cellular O-GlcNAcylation. By investigating correlation between elevated and increased expression lung cells, discovered promotes...

A data stream is a massive unbounded sequence of elements continuously generated at rapid rate. The continuous characteristic streaming necessitates the use algorithms that require only one scan over for knowledge discovery. Data mining streams should support flexible trade-off between processing time and accuracy. In many application areas, frequent itemsets has been suggested to find important by considering weight itemsets. this paper, we present an efficient algorithm WSFI (Weighted...

IL-33 has been implicated in the pathogenesis of asthma, atopic allergy, anaphylaxis, and other inflammatory diseases by promoting production proinflammatory cytokines chemokines or Th2 immune responses. In this study, we analyzed vivo effect administration. markedly promoted myelopoiesis bone marrow myeloid cell emigration. Concomitantly, induced hematopoietic stem progenitor (HSPC) mobilization extramedullary hematopoiesis. HSPC was mediated mainly through increased levels CCL7 produced...

Thermoelectric power waves, where multiwalled carbon nanotubes coated with cyclotrimethylene trinitramine (MWCNT/TNA) directly convert chemical energy to electricity, have received considerable attention recently. However, the low Seebeck coefficient of has been regarded as a hurdle increasing electrical potential. Here, we present Sb2Te3-coated MWCNT arrays prepared by sputtering method. An analytical model predicts an increase in annular multishell structure ∼75%. The heterostructure...

The decoupling and enhancement of both Seebeck coefficient electrical conductivity were achieved by constructing the c-axis preferentially oriented nanoscale Sb(2)Te(3) film on monolayer graphene. external graphene layer provided a highway for charge carriers, which stored in thicker binary telluride film, due to extremely high mobility.

This work presents a switched-capacitor (SC) DC-DC voltage regulator that converts 3.7V battery down to ~0.8V in order power the `brain' SoC of flapping-wing microrobotic bee. A cascade two 2:1 SC converters offers high efficiency for 4:1 conversion ratio. charge recycling technique reduces flying capacitor's bottom-plate parasitic loss by 50% and overall reaches 70%. The output droop is less than 10% nominal worst-case 47mA load step.

Voltage variations are a major challenge in processor design. Here, researchers characterize the voltage noise characteristics of programs as they run to completion on production Core 2 Duo processor. Furthermore, implications resilient architecture design for variation future systems.

Chronic graft-versus-host disease (cGVHD) is an increasingly frequent complication of allogeneic stem cell transplantation. We previously showed that anti-CD137 monoclonal antibody (mAb) can cure advanced cGVHD by inducing activation-induced death donor T cells. In this study, we examined whether administration mAb prevent the development after bone marrow transplantation (BMT) in mice conditioned with total body irradiation (TBI). used B10.D2→Balb/c (H-2d) minor histocompatibility...

Stronger amygdala-ventral prefrontal white matter connectivity has been associated with lower trait anxiety, possibly reflecting an increased capacity for efficient communication between the two regions. However, there are also reports arguing against this brain–anxiety association. To address these inconsistencies in literature, we tested possibility that idiosyncratic tract morphology may account meaningful individual differences even among those comparable microstructural integrity. Here,...

We investigated electrical conductivity and Vickers hardness of Ag- Ni-based composites prepared by powder metallurgy involving spark plasma sintering. The starting composition was Ag:Ni = 61:39 vol%, which provided an 3.30 × 105 S cm−1 a 1.27 GPa. addition bare multi-walled carbon nanotubes (MWNTs, 1.45 vol%) increased (1.31 GPa) but decreased (2.99 cm−1) carrier mobility (11 cm2 V−1 s−1) due to the formation Ni3C in interface between MWNTs Ni during prevented coating surface with Ag...

This study aimed to evaluate the association between initial fibrinogen levels and massive transfusion (MT) in emergency department (ED) patients with primary postpartum hemorrhage (PPH).

Abstract Wire-grid polarizers (WGPs) have been widely used in various fields, such as polarimetry, imaging, display, spectroscopy, and optical isolation. However, conventional WGPs diverse mid-wavelength infrared (MWIR) applications show high reflection losses, which intrinsically arise from refractive indices of their IR-transmitting substrates, silicon (Si) germanium (Ge). This study demonstrated the enhanced transmittance a transverse magnetic (TM) wave that surpassed ~80% over entire...