A5076089607- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Pancreatitis Pathology and Treatment
- Cancer Genomics and Diagnostics
- Pediatric Hepatobiliary Diseases and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neuroendocrine Tumor Research Advances
- Renal cell carcinoma treatment
- Esophageal and GI Pathology
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Research Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastric Cancer Management and Outcomes
- Gastrointestinal disorders and treatments
- Cancer Cells and Metastasis
- Cancer Treatment and Pharmacology
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Appendicitis Diagnosis and Management
- Gastrointestinal Bleeding Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Genetic factors in colorectal cancer
- Cancer Research and Treatments
- Cancer Diagnosis and Treatment
- Abdominal vascular conditions and treatments
Seoul National University Bundang Hospital
2016-2025
Seoul National University
2012-2025
National University College
2015-2024
New Generation University College
2012-2024
Kyung Hee University
2019-2022
Seoul National University Hospital
2011-2021
Weatherford College
2020
Dana-Farber Cancer Institute
2019
Kosin University Gospel Hospital
2017
Eulji University
2017
This study investigated the oral microbiome signatures associated with upper gastrointestinal (GI) and pancreaticobiliary cancers. Saliva samples from cancer patients age- sex-matched healthy controls were analyzed using 16S rRNA-targeted sequencing, followed by comprehensive bioinformatics analysis. Significant dissimilarities in microbial composition observed between across esophageal (EC), gastric (GC), biliary tract (BC), pancreatic (PC) groups (R2 = 0.067, 0.075, 0.068, 0.044; p 0.001,...
There is limited data on miRNA expression in pancreatic neuroendocrine tumors (PanNETs). In this study, we aimed to identify miRNAs that could be potential prognostic biomarkers of PanNETs patients who underwent curative surgery. For target screening, 2 primary and corresponding liver metastases were screened for by the NanoString nCounter analysis. Candidate selected ≥2-fold difference between metastatic versus tumor. validation, quantitative real-time PCR was performed candidate 37 matched...
Pembrolizumab appears promising for patients with programmed cell death ligand-1 (PD-L1)-positive solid tumors. However, data on immunotherapy biliary tract cancers (BTC) are limited. We aimed to investigate the predictive value of PD-L1 expression as an immunotherapeutic biomarker in BTC. Patients advanced BTC (n = 175) were screened using PharmDx assay and microsatellite instability (MSI) status. Of total 175 patients, 125 (71%) showed tumoral positivity (≥ 1%) while only two (2/142, 1.4%)...
Endoscopic ultrasonography-guided ethanol ablation therapy for pancreatic cystic lesions is a minimally invasive treatment but still an experimental therapy. The aims were to investigate the safety and efficacy of endoscopic therapy.The inclusion criteria following: clinically indeterminate in radiologic imaging studies, 2 5 cm unilocular or oligolocular cysts without communication main duct, patients with high-risk operation.There 91 study median follow-up 40 months. response rate was as...
Abstract Background and Aim Few studies compared endoscopic ultrasound (EUS)‐guided fine needle aspiration (EUS‐FNA) with retrograde cholangiopancreatography (ERCP)‐based tissue sampling in terms of diagnostic accuracy suspected malignant biliary obstruction. We evaluated the performance EUS‐FNA ERCP‐based sampling. Methods This multicenter study included 263 patients obstruction who underwent same‐session EUS ERCP between 2012 2016. Results Malignancies were confirmed 239 (90.9%) benign 24...
Next-generation sequencing (NGS) cancer profiling has gained traction in routine clinical practice South Korea. Here, we evaluated the use of NGS testing and genomically-matched therapies for patients with advanced solid tumors a real-world practice. We analyzed results from panel tests (SNUBH pan-cancer version 2) ordered June 2019 to 2020. Genomically-matched treatment was determined based on novel information obtained testing, while conventional molecular were excluded. A total 990...
Survival rates of patients with advanced pancreatic cancer (APC) have been improved palliative chemotherapy series. The current preferred first-line regimen consists combination therapy 5-fluorouracil (5-FU)/leucovorin (LV), irinotecan, and oxaliplatin (FOLFIRINOX) or gemcitabine plus albumin-bound paclitaxel (GNP). After failure chemotherapy, there are a few options for subsequent including switch to the unused nano-liposomal irinotecan 5-FU/LV. However, limited studies on efficacy...
812 Background: The spectrum of intraductal papillary mucinous neoplasm (IPMN) varies from benign cysts to carcinoma (IPMC). There is a lack large-scaled data on IPMC and high-grade dysplasia. We aimed study the real-world status treatment outcomes in South Korea. Methods: This retrospective, multicenter conducted reviewed electronic medical records patients who were histologically diagnosed with or (HG) dysplasia between 2011 2020, analyzed baseline characteristics, patterns, survival....
711 Background: In metastatic pancreatic cancer (MPC), hepatic metastasis is uniformly counted as just ‘one organ metastasis’ regardless of its tumor burden. This study aims to develop a novel stratification system for liver based on burden, and evaluate prognostic significance in MPC patients. Methods: Patients with treated at Seoul National University Bundang Hospital from 2011 2021 were included the training cohort. liver-only selected analysis. Liver burden was categorized by number...
The prognostic value of serial 18F-fluorodeoxyglucose positron emission tomography/ computed tomography (18F-FDG PET/CT) for patients with borderline resectable or locally advanced pancreatic cancer who undergo conversion surgery continue chemotherapy without has not been well-established. A retrospective analysis ductal adenocarcinoma was conducted at Seoul National University Bundang Hospital between March 2013 and February 2022. Patients underwent PET/CT baseline subsequent radiologic...
Several reports showed that interleukin-6 (IL-6) or -8 (IL-8) might be useful inflammatory biomarkers for pancreatic ductal adenocarcinoma (PDAC), although these clinical impact is still open to debate. The aim of this study was elucidate whether serum levels IL-6 and IL-8 at diagnosis could predict the tumor progression pattern PDAC, especially in extensive hepatic metastasis. According burden metastasis last follow-up, defined as follows: no limited (unilobar involvement 5 less within...
Cancer-associated fibroblasts are abundant in the desmoplastic stroma of pancreatic ductal adenocarcinomas and considered to play important roles tumor progression. In this study, we investigated expression status secreted protein acidic rich cysteine, periostin, fibroblast-activated protein, newly developed proCOL11A1 antibody surgically resected their prognostic implications. Tissue microarrays were constructed from 155 paired non-neoplastic pancreata another independent set 48...
Chromogranin A (CgA) is widely used as an immunohistochemical marker of neuroendocrine neoplasms and has been measurable in plasma patients. We assessed the clinical role CgA diagnosing pancreatic neoplasm (PNEN). was checked 44 patients with mass who underwent surgical resection from 2009 through 2011. The cutoff value for PNEN relationships between clinicopathologic variables were analyzed. Twenty-six PNENs 18 other disorders. ROC analysis showed a 60.7 ng/mL 77% sensitivity 56%...
Life expectancy of pancreatic ductal adenocarcinoma (PDAC) patients is usually short and selection the most appropriate treatment crucial. The aim this study was to investigate usefulness serum CA 19-9 as a surrogate marker under no impress excluding other factors affecting level than tumor itself.We recruited 1,446 with PDACs Lewis antigen both negative or obstructive jaundice were excluded eliminate false effects on level. clinicopathologic reviewed including initial post-treatment 19-9,...